Composition for treating atopy or pruritus comprising n-acetyl or n-acyl amino acid

Abstract

The present disclosure relates to a composition for preventing, alleviating or treating pruritus and/or atopy using an N-acetylamino acid or an N-acylamino acid having almost no side effects on the human body. Also, the present disclosure relates to a cosmetic composition for moisturizing skin or soothing skin. The composition of the present disclosure may be utilized to ameliorate a problematic skin condition caused by various causes, or to safely and effectively alleviate or treat pruritus and/or atopy without concern about side effects.

1 . A method for preventing or treating pruritus, comprising administering a composition to a subject in need thereof, wherein said composition comprises an N-acylamino acid selected from the group consisting of N-acetylalanine, N-acetylthreonine, N-acetylarginine, N-acetyltryptophan, N-propionyltryptophan, N-butyryltryptophan, N-pentanoyltryptophan, N-undecanoyltryptophan, N-palmitoyltryptophan, N-docos-13-enoyltryptophan, N-stearyltryptophan, N-oleoyltryptophan, N-acetyl-γ-glutammylalanine and N-palmitoylalanine; or a pharmaceutically acceptable salt thereof as an active ingredient. 
     
     
         2 . The method according to  claim 1 , wherein the N-acylamino acid is one or more amino acid selected from the group consisting of N-acetylalanine, N-acetylthreonine, N-acetylarginine and N-acetyltryptophan. 
     
     
         3 . The method according to  claim 2 , wherein the N-acylamino acid is selected from the group consisting of N-acetyl-L-alanine, N-acetyl-L-threonine, N-acetyl-L-arginine and N-acetyl-L-tryptophan. 
     
     
         4 . The method according to  claim 1 , wherein the N-acylamino acid is selected from the group consisting of N-propionyl-L-tryptophan, N-butyryl-L-tryptophan, N-pentanoyl-L-tryptophan, N-undecanoyl-L-tryptophan, N-palmitoyl-L-tryptophan, N-docos-13-enoyl-L-tryptophan, N-stearyl-L-tryptophan, N-oleoyl-L-tryptophan, N-acetyl-γ-glutammyl-L-alanine and N-palmitoyl-L-alanine. 
     
     
         5 . The method according to  claim 1 , wherein the pruritus is selected from the group consisting of vulvar pruritus, vaginal pruritus, paroxysmal pruritus, winter pruritus, anal pruritus, scrotal pruritus, aquagenic pruritus, scalp pruritus, nasal pruritus, oral pruritus and ocular pruritus. 
     
     
         6 . The method according to  claim 1 , wherein the composition is prepared into a formulation selected from the group consisting of a formulation for external application to skin, an aerosol, a spray, a collyrium, an oral medication and an injection.