Terpene-enriched cannabinoid composition and method of treatment

Abstract

A therapeutic product comprising at least one cannabinoid, at least one primary terpene, and at least 5% by weight of a non-cannabinoid, non-terpene carrier, wherein said non-cannabinoid, non-terpene carrier comprises cellulose and the terpenes to cannabinoids weight/weight ratio in said product is about 0.1 to about 1.0; a method of treating certain conditions and/or symptoms in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a product comprising at least one primary terpene; a therapeutic product comprising a primary terpene blend, wherein said primary terpene blend comprises five or less terpenes, and wherein each one of those terpenes, where present, independently comprises at least 10% of the total terpene content.

What is claimed is: 
     
         1 . A method of treating a condition or a symptom thereof in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a product comprising at least one cannabinoid, at least one primary terpene, and at least 5% by weight of a non-cannabinoid, non-terpene carrier, wherein (a) said non-cannabinoid, non-terpene carrier comprises at least 5% by weight cellulose, and a total terpenes to total cannabinoids weight/weight ratio in the composition is from about 0.1 to about 1.0, or (b) said non-cannabinoid, non-terpene carrier comprises less than 5% by weight cellulose, and a total terpenes to total cannabinoids weight/weight ratio in the composition is from about 0.05 to about 1.0,
 wherein said condition is selected from the group consisting of arthritis, osteoarthritis, arthralgia, joint pain, joint stiffness, diabetes, lack of appetite, anorexia, vomiting, nausea, an inflammatory bowel disease including Crohn's disease and ulcerative colitis, dementia, memory loss, osteoporosis, fatigue, weakness, decreased mental energy, decreased physical energy, dizziness, deficits in balance, itchy skin, pruritus and/or chronic pruritus, wrinkles, stretch marks, skin burn, headache, migraine, weight gain, digestive problem, intestinal disorder, gastrointestinal pain, abdominal pain, pelvic pain, constipation, diarrhea, hot flashes, sweating, difficulty in concentration, weakened immune system, cardiovascular disease, palpitation and tachycardia, psoriasis, dermatophytes,  Candida , leishmaniasis, Methycillin-resistant  Staphylococcus aureus  (MRSA), malaria, allergy, fibromyalgia, nociceptive pain, neuropathic pain, pain, arm or leg pain, acne, insomnia and/or sleep disorders, muscle pain, myalgia, spasticity, muscle tension, cramps, spasms, anxiety, irritability, nervousness, restless, stress, depression, mood problem, affect disorders, anger, autism and/or autism spectrum disorder, neurodegenerative diseases, Alzheimer disease, Parkinson disease, Huntington's disease, Dystonia, Amyotrophic Lateral Sclerosis (ALS), multiple sclerosis, Tourette syndrome, Myasthenia Gravis, epilepsy, cancer, inflammatory airway diseases including asthma and/or chronic obstructive pulmonary disease (COPD), addiction, stroke, traumatic brain injury, motor spasm and/or tic, vocal tic, obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), attention deficit disorder (ADD), cerebral palsy (CP), inflammation, oxidative stress, paresthesia, glaucoma and combinations thereof.   
     
     
         2 . The method of  claim 1 , wherein said primary terpene is selected from the group consisting of pinene, limonene, linalool, caryophyllene, caryophyllene oxide, myrcene, humulene, borneol, eucalyptol, terpineol, nerolidol, phytol, geraniol, bisabolol, camphene, amyrin, thujone, citronellol, pulegone, cycloartenol, cymene, sabinene, carene, terpinene, fenchol, isopulegol, guaiol, phellandrene, eudesmol, ocimene, cardinol, elemene, friedelin, carvacrol, eugenol, camphor, menthol, iso-menthone, neral, gerial, viridiflorol, germacrene, thymol, Menth-2-en-1-ol, farensol, carotol, myrtenol and combinations thereof. 
     
     
         3 . The method of  claim 1 , wherein said condition is associated with aging, and wherein said primary terpene is selected from the group consisting of caryophyllene, linalool, pinene, eucalyptol, sabinene, terpineol and combinations thereof. 
     
     
         4 . The method of  claim 1 , wherein said subject is a child, and wherein said primary terpene is selected from the group consisting of caryophyllene, limonene, pinene, terpineol and combinations thereof. 
     
     
         5 . The method of  claim 1 , wherein said product comprises tetrahydrocannabinol (THC) at a concentration of less than 5% by weight, and at least 0.5% by weight primary terpene, and wherein said primary terpene is selected from the group consisting of limonene, linalool, eucalyptol, myrcene, caryophyllene, terpineol and combinations thereof; or wherein said product comprises CBD and THC at CBD to THC weight/weight ratio greater than 1, wherein CBD concentration is less than 20% by weight, wherein primary terpene concentration is at least 0.5% by weight, and wherein said primary terpene is selected from the group consisting of linalool, terpineol, ocimene, humulene, caryophyllene, eucalyptol, pinene, limonene and combinations thereof. 
     
     
         6 . The method of  claim 1 , wherein said product is selected from the group consisting of tablets, gel capsules, medical patches, topicals, creams, varnishes, sublingual oils, sprays, edibles, beverages, suppositories, tampons, rectal candles, cigarettes, vaporizer liquids, nasal preparations, preparations containing micro-emulsions, preparations comprising nano-emulsions, preparations containing micro-particles, preparations comprising nano-particles and combinations thereof. 
     
     
         7 . The method of  claim 1 ,
 wherein when said condition comprises diabetes, said product comprises CBD and optionally THC and/or CBN at CBD to THC weight/weight ratio greater than 1, and said primary terpene is selected from the group consisting of limonene, pinene, linalool, humulene, myrcene, phytol, geraniol, bisabolol, borneol, guaiol, ocimene, fenchol, terpineol, terpinene, eucalyptol and combinations thereof;   wherein when said condition comprises inflammatory bowel disease including Crohn's disease and ulcerative colitis, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, said primary terpene is selected from the group consisting of limonene, caryophyllene, borneol, myrcene, pinene, terpinene, isopulegol, phellandrene, carene, carvacol, terpineol, humulene and combinations thereof, and said product optionally comprises at least one of linalyl acetate, geranyl acetate, eugenol, eugenyl acetate, piperine and combinations thereof; and   wherein when said condition comprises stimulation of the immune system and/or a weakened immune system, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, and said primary terpene is selected from the group consisting of linalool, pinene, borneol, caryophyllene, geraniol, amyrin, terpinene, myrcene, eucalyptol, humulene and combinations thereof.   
     
     
         8 . The method of  claim 1 ,
 wherein when said condition comprises Fibromyalgia, said primary terpene is selected from the group consisting of linalool, caryophyllene, limonene, humulene, eucalyptol, amyrin, cycloartenol, pinene, sabinene, myrcene, terpinene, borneol, bisabolol and combinations thereof;   wherein when said condition comprises nociceptive pain, said primary terpene is selected from the group consisting of myrcene, linalool, caryophyllene, eucalyptol, cycloartenol, borneol, sabinene, camphene, terpineol, citronellol, geraniol, humulene, bisabolol, limonene and combinations thereof;   wherein when said condition comprises neuropathic pain, said primary terpene is selected from the group consisting of caryophyllene, linalool, eucalyptol, amyrin, borneol, pinene, terpineol, limonene, nerolidol, geraniol, myrcene and combinations thereof;   wherein when said condition comprises pain, said primary terpene is selected from the group consisting of myrcene, linalool, humulene, eucalyptol, caryophyllene, caryophyllene oxide, amyrin, cycloartenol, borneol, sabinene, camphene, nerolidol, terpineol, geraniol, citronellol, camphor, bisabolol, limonene and combinations thereof, and said product optionally comprises at least one of linalyl acetate, geranyl acetate, eugenol, eugenyl acetate, piperine, methylis-oeugenol, Methyleugenol, menthol and a herbal extract selected from the group consisting of extracts of  angelica sinensis, piscidia erythrina, tanacetum parthenium, viburnum opulus, boswellia  spp,  capsicum  spp,  corydalis yanhusuo, harpagophytum procumbens, Rosmarinus officinalis, salix alba, zingiber officinalis  and combinations thereof; and   wherein when said condition comprises arm or leg pain, said primary terpene is selected from the group consisting of linalool, terpinene, pinene, limonene, terpineol, myrcene, nerolidol and combinations thereof.   
     
     
         9 . The method of  claim 1 ,
 wherein when said condition is selected from the group consisting of neurodegenerative diseases including Alzheimer, Parkinson disease, Huntington's disease, dystonia and Amyotrophic lateral sclerosis (ALS) and combinations thereof, said primary terpene is selected from the group consisting of terpineol, caryophyllene, myrcene, terpineol, linalool, humulene, eucalyptol, pinene, pulegone, cymene, ocimene, limonene, nerolidol, sabinene, carene, citronellol, geraniol, menthol, borneol, terpinene, bisabolol, fenchol and combinations thereof, and said product optionally comprises at least one selected from the group consisting of linalyl acetate, geranyl acetate, menthol, piperine, eugenol, citronellyl formate, jasmone, benzy acetate, benzyl alcohol and combinations thereof;   wherein when said condition comprises multiple sclerosis, said primary terpene is selected from the group consisting of caryophyllene, pinene, myrcene, limonene, humulene, citronellol, eucalyptol, caryophyllene oxide, linalool, amyrin, cycloartenol, cymene, terpinene, borneol, pulegol, nerolidol, terpineol, sabinene, geraniol and combinations thereof;   wherein when said condition comprises Myasthenia gravis, said primary terpene is selected from the group consisting of pinene, terpineol, eucalyptol, pulegone, cymene, ocimene, nerolidol, limonene, linalool, citronellol, geraniol, menthol, caryophyllene, borneol and combinations thereof; and   wherein when said condition and/or symptom comprises epilepsy, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, and said primary terpene is selected from the group consisting of linalool, terpineol, ocimene, myrcene, limonene, caryophyllene and combinations thereof.   
     
     
         10 . The method of  claim 1 ,
 wherein when said condition comprises a cancer and/or a cancer related symptom, said primary terpene is selected from the group consisting of myrcene, limonene, caryophyllene, caryophyllene oxide, terpinene, citronellol, linalool, geraniol, menthol, humulene, amyrin, cycloartenol, pinene, camphene, eucalyptol, terpineol, borneol and combinations thereof, and said product optionally comprises at least one selected from the group consisting of linalyl acetate, geranyl acetate, eugenol, eugenyl acetate, piperine, methylis-oeugenol, Methyleugenol, menthol and combination thereof;   wherein when said condition comprises stroke and/or traumatic brain injury, said primary terpene is selected from the group consisting of myrcene, terpinene, caryophyllene, caryophyllene oxide, pinene, limonene, humulene, citronellol, eucalyptol, linalool, amyrin, cycloartenol, terpineol, thymol, eucalyptol, geraniol, carvacrol, thymol, cardinol, menth-2-en-1-ol, carotol and combinations thereof;   wherein when said condition comprises an addiction, including addiction to drugs, smoking, drinks, food, gambling, sex, and sports, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, and said primary terpene is selected from the group consisting of caryophyllene, pinene, myrcene, limonene, linalool, terpineol and combinations thereof; and   wherein when said condition comprises asthma and/or chronic obstructive pulmonary disease (COPD), said product comprises THC and optionally CBD at THC to CBD weight/weight ratio greater than 1, and said primary terpene is selected from the group consisting of pinene, eucalyptol, limonene, humulene, camphene, caryophyllene and combinations thereof.   
     
     
         11 . The method of  claim 1 ,
 wherein when said condition comprises cerebral palsy (CP), said primary terpene is selected from the group consisting of myrcene, pinene, linalool, humulene, nerolidol, limonene, terpineol, sabinene and combinations thereof;   wherein when said condition comprises autism and/or autism spectrum disorder, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, and said primary terpene is selected from the group consisting of limonene, caryophyllene, pinene, myrcene, humulene, citronellol, eucalyptol, linalool, terpinen-4-ol, ocimene, geraniol, menthol, borneol, bisabolol, fenchol and combinations thereof;   wherein when said condition is selected from the group consisting of attention deficit hyperactivity disorder (ADHD), attention deficit disorder (ADD), obsessive-compulsive disorder (OCD) and combinations thereof, said primary terpene is selected from the group consisting of linalool, eucalyptol, terpineol, myrcene, pinene, pulegone, caryophyllene, geraniol, citronellol, menthol, caryophyllene, pinene, borneol, bisabolol, fenchol and combinations thereof; and   wherein when said condition comprises Tourette syndrome and/or vocal tics, said primary terpene is selected from the group consisting of myrcene, linalool, limonene, pinene, nerolidol, caryophyllene, eucalyptol, geraniol, menthol, borneol, bisabolol, fenchol and combinations thereof.   
     
     
         12 . The method of  claim 1 ,
 wherein when said condition comprises allergy, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, and said primary terpene is selected from the group consisting of camphene, pinene, borneol, caryophyllene, geraniol, and combinations thereof;   wherein when said condition comprises osteoporosis, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, said primary terpene is selected from the group consisting of caryophyllene, caryophyllene oxide, carene, eucalyptol, sabinene, pinene, limonene, borneol, thymol, camphor and combinations thereof, and said product optionally comprises at least one herbal extract selected from the group consisting of extracts of extracts of  angelica sinensis, cimicifuga  ( Actaea )  racemosa, dioscorea villosa, Trifolium pratense  and combinations thereof;   wherein when said condition comprises insomnia and/or sleep disorders, said primary terpene is selected from the group consisting of linalool, myrcene, caryophyllene, eucalyptol, terpineol, citronellol, pinene, terpinene, nerolidol, eucalyptol, sabinene, pinene, limonene, borneol, fenchol, bisabolol, humulene, phytol, citral and combinations thereof, and said product optionally comprises at least one selected from the group consisting of linalyl acetate and/or chamazulene and a herbal extract selected from the group consisting of extracts of extracts of  Avena sativa, cimicifuga  ( actaea )  racemosa, Humulus lupulus, hypericum perforatum, lavendula officinalis, Melissa officinalis, Passiflora incarnata, valeriana officinalis  and combinations thereof; and   wherein when said condition is selected from the group consisting of anxiety, irritability, nervousness, restless, stress, depression, general discomfort and affect disorder and combinations thereof, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1 said primary terpene is selected from the group consisting of limonene, linalool, terpineol, citronellol, eucalyptol, caryophyllene, geraniol, menthol, iso-menthone, germacrene, pinene, cardinol, neral, geranial, myrcene, terpinene, menth-2-en-1-ol, humulene, bisabolol, borneol, fenchol, nerolidol, phellandrene and combinations thereof, and said product optionally comprises at least one selected from the group consisting of linalyl acetate, geranyl acetate, menthol, piperine, eugenol, citronellyl formate, jasmone, benzy acetate, benzyl alcohol and a herbal extract selected from the group consisting of extracts of  Avena sativa, bacopa monnieri, centella  ( Hydrocotyl )  asiatica, Humulus lupulus, hypericum perforatum, Melissa officinalis, Passiflora incarnata, valeriana officinalis  and combinations thereof.   
     
     
         13 . The method of  claim 1 ,
 wherein when said condition is selected from the group consisting of difficulty in concentrating, memory loss, dementia and combinations thereof, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, said primary terpene is selected from the group consisting of pinene, pulegone, eucalyptol, terpineol, cymene, ocimene, limonene, linalool, caryophyllene, humulene, carene and combinations thereof, and said product optionally comprises at least one herbal extract selected from the group consisting of extracts of  asphalentum ponjabianum—mumio, bacopa monnieri, centella  ( hydrocotyl )  asiatica, eleutherococcus senticosus, Ginkgo biloba, lepidium meyenii, lycium barbarum, paullinia cupana, Rhodiola rosea  and combinations thereof;   wherein when said condition is selected from the group consisting of muscle pain, myalgia, spasticity, muscle tension, cramps, spasms and combinations thereof, said primary terpene is selected from the group consisting of myrcene, pinene, nerolidol, linalool, caryophyllene, limonene humulene, bisabolol, sabinene, citral, eucalyptol, terpineol, geraniol and combinations thereof, and said product optionally comprises at least one herbal extract selected from the group consisting of extracts of  angelica sinensis, piscidia erythrina, tanacetum parthenium, viburnum opulus, boswellia  spp,  capsicum  spp,  corydalis yanhusuo, harpagophytum procumbens, Rosmarinus officinalis, salix alba, zingiber officinalis, chamaemelum, valeriana edulis  and combinations thereof;   wherein when said condition is selected from the group consisting of fatigue, weakness, decreased mental energy, decreased physical energy, dizziness, deficits in balance and combinations thereof, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, said primary terpene is selected from the group consisting of pinene, terpinene, linalool, eucalyptol, myrcene, terpineol, limonene, caryophyllene, borneol and combinations thereof and said product optionally comprises at least one herbal extract selected from the group consisting of extracts of  eleutherococcus senticosus, Ganoderma lucidum, grifola frondosa, lentinula edodes, lepidium meyenii, panax ginseng, Rhodiola rosea  and combinations thereof; and   wherein when said condition comprises headache and/or migraine, said primary terpene is selected from the group consisting of myrcene, linalool, caryophyllene, eucalyptol, limonene, nerolidol, fenchol, humulene, guaiol, borneol, bisabolol and combinations thereof, and said product optionally comprises at least one herbal extract selected from the group consisting of extracts of  angelica sinensis, corydalis yanhusuo, piscidia erythrina, Rosmarinus officinalis, stachys betonica, tanacetum parthenium, verbena officinalis  and combinations thereof.   
     
     
         14 . The method of  claim 1 ,
 wherein when said condition comprises weight gain and/or reduction of appetite, said product comprises CBD and optionally THC at CBD to THC weight/weight ratio greater than 1, said primary terpene is selected from the group consisting of eucalyptol, caryophyllene, limonene, humulene, phytol and combinations thereof, and said product optionally comprises at least one herbal extract selected from the group consisting of extracts of  ephedra sinica, foeniculum vulgare, fucus vesiculosus, garcinia cambogia, gymnema sylvestre, laminaria  spp,  paullinia cupana  and combinations thereof;   wherein when said condition is selected from the group consisting of digestive problem, intestinal disorder, gastrointestinal pain, abdominal pain (colic), pelvic pain, constipation, diarrhea and combinations thereof, said primary terpene is selected from the group consisting of limonene, cymene, ocimene, terpinene, caryophyllene, citronellol, sabinene, linalool, pinene, myrcene, germacrene, geraniol, nerolidol, menthol, humulene, fenchol, borneol and combinations thereof, and said product optionally comprises at least one of piperine and a herbal extract selected from the group consisting of extracts of  angelica sinensis, piscidia erythrina, tanacetum parthenium, viburnum opulus, boswellia  spp,  capsicum  spp,  corydalis yanhusuo, harpagophytum procumbens, Rosmarinus officinalis, salix alba, zingiber officinalis  and combinations thereof;   wherein when said condition is selected from the group consisting of lack of appetite, nausea, vomiting, anorexia and combinations thereof, said product comprises THC and optionally CBD at THC to CBD weight/weight ratio greater than 1, and said primary terpene is selected from the group consisting of linalool, citronellol, geraniol, menthol, humulene, bisabolol, borneol, fenchol, linalool, limonene, terpineol, pinene, caryophyllene, myrcene, cymene, terpinene and combinations thereof; and   wherein when said condition is selected from the group consisting of joint pain, joint stiffness, arthralgia, arthritis, osteoarthritis, and combinations thereof said primary terpene is selected from the group consisting of myrcene, linalool, caryophyllene, eucalyptol, pinene, nerolidol, sabinene, limonene, terpinene, menth-2-en-1-ol, terpineol, geraniol, guaiol, humulene, bisabolol, borneol, fenchol and combinations thereof, and said product optionally comprises at least one selected from the group consisting of linalyl acetate, geranyl acetate, eugenol, methylis-oeugenol, menthol, eugenyl acetate, piperine and a herbal extract selected from the group consisting of extracts of  boswellia  spp,  capsicum  spp,  corydalis yanhusuo, harpagophytum procumbens, piscidia erythrina, salix alba, zingiber officinalis  and combinations thereof.   
     
     
         15 . The method of  claim 1 ,
 wherein when said condition is selected from the group consisting of hot flashes, night sweat, palpitation, irritability, restlessness and combinations thereof, said primary terpene is selected from the group consisting of caryophyllene, myrcene, humulene, pinene, linalool, limonene, nerolidol, terpinene, terpineol, geraniol, carene, citronellol, eucalyptol, sabinene, myrtenol, bisabolol, borneol, fenchol and combinations thereof, and said product optionally comprises at least one selected from the group consisting of linalyl acetate, geranyl acetate, citronellyl formatea and a herbal extract selected from the group consisting of extracts of extracts of  angelica sinensis, anemarrhenae asphodeloides, cimicifuga  ( actaea )  racemosa, dioscorea villosa, salvia officinalis, salvia officinalis, rehmania glutinosa preparata  and combinations thereof;   wherein when said condition is selected from the group consisting of inflammation, oxidative stress, paresthesia and combinations thereof, said primary terpene is selected from the group consisting of caryophyllene, pinene, myrcene, limonene, humulene, citronellol, eucalyptol, linalool, beta amyrin, cycloartenol, terpinene, terpineol, geraniol, carvacrol, thymol, cardinol, menth-2-en-1-ol, carotol, nerolidol and combinations thereof, said product optionally comprises at least one of linalyl acetate, geranyl acetate, eugenol, eugenyl acetate, piperine and combinations thereof; and   wherein when said condition is selected from the group consisting of cardiovascular disease, palpitation, tachycardia and combinations thereof, said primary terpene is selected from the group consisting of linalool, camphene, limonene, pinene, borneol and combinations thereof, and said product optionally comprises at least one herbal extract selected from the group consisting of extracts of extracts of  cimicifuga  ( actaea )  racemosa, crataegus  spp,  leonurus  spp,  Passiflora incarnata  and combinations thereof.   
     
     
         16 . The method of  claim 1 , wherein said condition and/or symptom comprises a side effect associated with  cannabis  consumption,
 wherein when said side effect comprises hypoglycemia and/or reduction of glucose level, said primary terpene comprises geraniol;   wherein when said side effect is selected from the group consisting of fatigue, weakness, dizziness, deficits in balance and combinations thereof, said primary terpene is selected from the group consisting of pinene, terpinene, linalool, eucalyptol, myrcene, terpineol, limonene, caryophyllene, borneol and combinations thereof;   wherein when said side effect comprises palpitation and/or tachycardia, said primary terpene is selected from the group consisting of camphene, limonene, pinene, borneol and combination thereof;   wherein when said side effect comprises digestive disorders including vomiting and/or diarrhea, said primary terpene is selected from the group consisting of linalool, citronellol, geraniol, menthol, humulene, bisabolol, borneol, fenchol, linalool, limonene, terpineol, pinene, caryophyllene, myrcene, cymene, terpinene and combination thereof;   wherein when said side effect comprises headache, said primary terpene is selected from the group consisting of myrcene, linalool, caryophyllene, eucalyptol, limonene, nerolidol, fenchol, humulene, guaiol, borneol, bisabolol and combinations thereof;   wherein when said side effect comprises coughing, said primary terpene is selected from the group consisting of pinene, eucalyptol, limonene and combinations thereof;   wherein when side effect comprises impaired fertility, said primary terpene is selected from the group consisting of linalool, terpineol, geraniol, thujone, camphor, viridiflorol, borneol, champhene, pinene, eucalyptol, caryophyllene, germacrene, pinene, carene, cirtonellol, nerol, farnesol, limonene, myrcene, terpinene, menth-2-en-1-ol, carotol, sabinene, neral, geranial and combination thereof;   wherein when said side effect comprises increased appetite, said primary terpene is selected from the group consisting of eucalyptol, caryophyllene, limonene, humulene, phytol and combinations thereof;   wherein when said side effect is selected from the group consisting of impaired memory, impaired concentration, impaired perception and combinations thereof, said primary terpene is selected from the group consisting of pinene, pulegone, eucalyptol, terpineol, cymene, ocimene, limonene, linalool, caryophyllene, humulene, carene and combinations thereof; and   wherein when said side effect comprises anxiety and/or psychotic-like effects, said primary terpene is selected from the group consisting of limonene, linalool, caryophyllene, eucalyptol, pinene, myrcene, terpinene, nerolidol, terpineol, geraniol, menthol, citronellol, neral, geraniol, menthol, borneol, phellandrene, bisabolol, fenchol, humulene and combinations thereof.