Multimodal therapy for cancer cell destruction

Abstract

The field of the disclosure relates generally to cancer cell destruction and, more specifically, to cancer cell destruction by photo-magnetic irradiation mediated multimodal therapy using smart nanostructures.

What is claimed is: 
     
         1 . A multimodal method of cancer cell destruction, the method comprising:
 applying optical irradiation induced temperature change to at least one nanostructure comprising a cluster of nanoparticles;   simultaneously applying an oscillating magnetic field to the at least one nanostructure, wherein the cluster of nanoparticles comprises at least one thermo-responsive polymeric nanoparticle comprising cisplatin (CPNP), and wherein the simultaneous optical irradiation induced temperature change and oscillating magnetic field application creates a sustained release of the cisplatin from the CPNP; and,   interacting the released cisplatin with at least one cancer cell to destroy the cell.   
     
     
         2 . The method of  claim 1 , wherein the simultaneous irradiation and application of the oscillating magnetic field occur with an incubator-actuator device. 
     
     
         3 . The method of  claim 1 , wherein the magnetic field has an intensity of from about 0 Oe to about 150 Oe. 
     
     
         4 . The method of  claim 1 , wherein the magnetic field has a frequency of from about 0 kHz to about 1,000 kHz. 
     
     
         5 . The method of  claim 1 , wherein the nanostructure comprises the at least one CPNP nanoparticle at a concentration of from about 50 μg/ml to about 600 μg/ml. 
     
     
         6 . The method of  claim 1 , wherein the at least one CPNP comprises multiple shells. 
     
     
         7 . The method of  claim 1 , wherein the at least one CPNP comprises an inner shell and an outer shell, the inner shell having a diameter of from about 50 nm to about 300 nm and the outer shell having a diameter of from about 50 nm to about 400 nm. 
     
     
         8 . The method of  claim 1 , wherein the cluster of nanoparticles comprises at least one core-shell magnetic nanosphere (CSMNS) nanoparticle. 
     
     
         9 . The method of  claim 1 , wherein the cluster of nanoparticles comprises at least one capped gold nanoparticle (AuNP). 
     
     
         10 . A multimodal method of cancer cell destruction, the method comprising:
 interacting at least one nanostructure with at least one cancer cell, wherein the at least one nanostructure comprises a cluster of nanoparticles, and wherein the cluster comprises at least one core-shell magnetic nanosphere (CSMNS) nanoparticle;   applying optical irradiation induced temperature change to the at least one nanostructure;   simultaneously applying an oscillating magnetic field to the at least one nanostructure; and   inducing a coupled hyperthermia and oxidative stress to destroy the at least one cancer cell through the simultaneous optical irradiation and oscillating magnetic field application.   
     
     
         11 . The method of  claim 10 , wherein the simultaneous application of optical irradiation and oscillating magnetic field occur with an incubator-actuator device. 
     
     
         12 . The method of  claim 10 , wherein the oscillating magnetic field has an intensity of from about 0 Oe to about 150 Oe. 
     
     
         13 . The method of  claim 10 , wherein the oscillating magnetic field has a frequency of from about 0 kHz to about 1,000 kHz. 
     
     
         14 . The method of  claim 10 , wherein the at least one CSMNS nanoparticle has a diameter of from about 50 nm to about 400 nm. 
     
     
         15 . The method of  claim 10 , wherein the nanostructure comprises the at least one CSMNS nanoparticle at a concentration of from about 200 μg/ml to about 600 μg/ml. 
     
     
         16 . The method of  claim 10 , wherein the at least one CSMNS nanoparticle comprises a magnetic nanoparticle (MNP) core and a polymer shell. 
     
     
         17 . The method of  claim 16 , wherein the MNP core is selected from at least one of magnetite, ferric oxide, maghemite, gadolinium-doped cobalt ferrite, and combinations thereof. 
     
     
         18 . The method of  claim 16 , wherein the polymer shell comprises polyvinylpyrrolidone (PVP). 
     
     
         19 . The method of  claim 10 , wherein the at least one CSMNS nanoparticle comprises at least one capped gold nanoparticle (AuNP). 
     
     
         20 . The method of  claim 19 , wherein the at least one capped AuNP is capped with a material comprising at least one of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), poly(N-isopropylacrylamide) (PNIPAM), dextran, dimercaptosuccinic acid (DMSA) and combinations thereof.