Compositions and methods for modulating wound healing and regeneration

Abstract

The present disclosure relates to compositions and methods for modulating wound healing and regeneration. More particularly, the present disclosure relates to immunomodulatory agents that promote wound healing and tissue regeneration, and that may be optionally used in combination with synthetic or bio-material scaffolds.

1 . A method for treating a wound in a subject, the method comprising administering to the subject an effective amount of a scaffold and an immunomodulatory agent, thereby treating the wound. 
     
     
         2 . The method of  claim 1 , wherein the scaffold comprises a biomaterial or a synthetic material. 
     
     
         3 . The method of  claim 2 , wherein the biomaterial scaffold is a tissue-derived scaffold or a collagen scaffold. 
     
     
         4 . The method of  claim 1 , wherein the immunomodulatory agent induces an adaptive immune system response. 
     
     
         5 . The method of  claim 1 , wherein the immunomodulatory agent is selected from the group consisting of Mineral salt adjuvants, Tensoactive adjuvants, Bacteria-derived adjuvants, Adjuvant emulsions, Liposome adjuvants, Polymeric microsphere adjuvants, Cytokines as adjuvants, Inulin-derived adjuvants, carbohydrate adjuvants, Adjuvant formulations, Mucosal adjuvants, Cytokines, and Cancer vaccine adjuvants. 
     
     
         6 . The method of  claim 1 , wherein the immunomodulatory agent is a protein or small molecule. 
     
     
         7 . The method of  claim 6 , wherein the small molecule is a peptide. 
     
     
         8 . The method of  claim 1 , wherein a rate of wound healing is increased by 2%, 4%, 6%, 8%, or 10%. 
     
     
         9 . The method of  claim 1 , wherein the scaffold is impregnated with the immunomodulatory agent. 
     
     
         10 . The method of  claim 1 , wherein the wound is an acute wound, a chronic wound, or a surgical wound. 
     
     
         11 . A method for treating a wound in a subject, the method comprising administering to the subject an effective amount of an immunomodulatory agent, thereby treating the wound. 
     
     
         12 . The method of  claim 11 , wherein the immunomodulatory agent is administered with a scaffold. 
     
     
         13 . The method of  claim 12 , wherein the scaffold comprises a biomaterial or a synthetic material. 
     
     
         14 . The method of  claim 13 , wherein the biomaterial scaffold is a tissue-derived scaffold or a collagen scaffold. 
     
     
         15 . The method of  claim 11 , wherein the immunomodulatory agent induces an adaptive immune system response. 
     
     
         16 . The method of  claim 11 , wherein the immunomodulatory agent is selected from the group consisting of Mineral salt adjuvants, Tensoactive adjuvants, Bacteria-derived adjuvants, Adjuvant emulsions, Liposome adjuvants, Polymeric microsphere adjuvants, Cytokines as adjuvants, Inulin-derived adjuvants, carbohydrate adjuvants, Adjuvant formulations, Mucosal adjuvants, Cytokines, and Cancer vaccine adjuvants. 
     
     
         17 . The method of  claim 11 , wherein the immunomodulatory agent is a protein or small molecule. 
     
     
         18 . The method of  claim 17 , wherein the small molecule is a peptide. 
     
     
         19 . The method of  claim 11 , wherein a rate of wound healing is increased by 2%, 4%, 6%, 8%, or 10%. 
     
     
         20 . The method of  claim 11 , wherein the wound is an acute wound, a chronic wound, or a surgical wound. 
     
     
         21 - 66 . (canceled)