Compositions comprising quillaja extract and methods of preparations and use thereof

Abstract

The present embodiments are directed to compositions comprising quillaja extract and at least one active ingredient such as nutritional supplement, dietary ingredient, medicine, and food additive, and methods for preparations and use thereof.

What is claimed is: 
     
         1 . A composition comprising quillaja extract and at least one active ingredient, wherein the active ingredient is lipid soluble. 
     
     
         2 . The composition of  claim 1 , wherein the active ingredient is selected from the group consisting of a nutritional supplement, a dietary ingredient, a medicine, and a food additive. 
     
     
         3 . The composition of  claim 1 , wherein the active ingredient is a quinone, a pyrroloquinoline quinone (PQQ), a cannabinoid, a  curcuma  isolate, berberine, diindolylmethane (DIM), a phenolic, a lipid-soluble vitamin, a symmetrical carotenoid, an omega-3 fatty acid, a terpenoid, or any combination thereof. 
     
     
         4 . The composition of  claim 1 , wherein the active ingredient is CoQ10, reduced CoQ10, oxidized CoQ10, vitamin K-2, cannabidiol, tetrahydrocannabinol, tumerone, curcumene, xanthorrhizol, curcumin, berberine, diindolylmethane (DIM), resveratrol, quercetin, vitamin A, vitamin D, vitamin E, vitamin K, beta-carotene, zeaxanthin, lycopene, astaxanthin, an omega-3 fatty acid, a mono-terpenoid, a di-terpenoid, a tri-terpenoid, a sesqui-terpenoid, or any combination thereof. 
     
     
         5 . The composition of  claim 3 , wherein the quinone is emodin, embelin, or the combination thereof, wherein the terpenoid is lutein, wherein the lipid-soluble vitamin is a phytosterol or phytosterol ester, wherein the omega-3 fatty acid is a docosahexaenoic acid (DHA), an eicosapentaenoic acid (EPA), or the combination thereof. 
     
     
         6 . The composition of  claim 5 , wherein the phytosterol is beta-sitosterol, stigmasterol, campesterol, or the combination thereof, or wherein the phytosterol ester is beta-sitosterol ester, stigmasterol ester, campesterol ester, or the combination thereof. 
     
     
         7 . The composition of  claim 4 , wherein the vitamin K-2 is MK2, MK3, MK4, MK5, MK6, MK7, MK8, MK9, MK10, MK11, MK12, MK13, or any combination thereof. 
     
     
         8 . The composition of  claim 7 , wherein the vitamin K-2 is MK4, MK7, or the combination thereof. 
     
     
         9 . The composition of  claim 7 , further comprising geranylgeraniol. 
     
     
         10 . The composition of  claim 4 , wherein the active ingredient is CoQ10. 
     
     
         11 . The composition of  claim 10 , further comprising geranylgeraniol. 
     
     
         12 . The composition of  claim 10 , wherein the CoQ10 is ubiquinol, ubiquinone, or a mixture of ubiquinol and ubiquinone, or wherein the CoQ10 is a mixture of ubiquinol and ubiquinone and the ubiquinol is less than 95% by weight in the mixture. 
     
     
         13 . The composition of  claim 1 , wherein the weight ratio of the quillaja extract to the active ingredient is from about 12:75 to about 75:25 or about 25:75 to about 75:25. 
     
     
         14 . The composition of  claim 1 , wherein the quillaja extract contains about 10% to about 40% or about 20% to about 30% of quillaja saponin by weight. 
     
     
         15 . The composition of  claim 1 , wherein the composition is in a form of soft capsule, hard capsule, tablet, gel capsule, softgel, 2-piece liquid-filled capsule, bar, confectionary, chocolate, powder, oral suspension, pill, hard-shell, truffle, ganache, truffle ganache, gum, gummy, chewable form, an effervescent packet or pouch, an eye drop, or an aerosol spray. 
     
     
         16 . The composition of  claim 1 , wherein the composition further comprises at least one triglyceride, at least one phospholipid, at least one tocotrienol, at least one tocopherol, or a combination thereof. 
     
     
         17 . The composition of  claim 16 , wherein the triglyceride is a medium-chain triglyceride (MCT), wherein the triglyceride is a short-chain triglyceride (SCT), wherein the triglyceride is a triacetin, wherein the phospholipid is a lecithin, wherein the tocotrienol is alpha, beta, gamma, delta, or any combination thereof, or wherein the tocopherol is alpha, beta, gamma, delta, or any combination thereof. 
     
     
         18 . The composition of  claim 1 , wherein the active ingredient is tocotrienol or 5-methyltetrahydrofolic acid glucosamine salt (5-MTHF). 
     
     
         19 . The composition of  claim 18 , wherein the tocotrienol is alpha, beta, gamma, delta, or any combination thereof. 
     
     
         20 . A method of increasing bioaccessibility and/or bioavailability of the active ingredient in a subject in need thereof, the method comprising administering the composition of  claim 1  to the subject in need thereof thereby increasing the bioaccessibility and/or bioavailability of the active ingredient in the subject.