US2023270554A1PendingUtilityA1

Biodegradable piezoelectric nanofiber scaffold for bone or tissue regeneration

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Assignee: UNIV CONNECTICUTPriority: Mar 1, 2019Filed: May 2, 2023Published: Aug 31, 2023
Est. expiryMar 1, 2039(~12.6 yrs left)· nominal 20-yr term from priority
Inventors:Thanh Duc NguyenRitopa Das
A61F 2/28A61L 27/58A61L 27/34A61L 27/18A61L 27/54A61L 27/3847A61L 2430/02A61F 2002/2864A61F 2002/2821A61F 2002/30062A61F 2/2846A61F 2002/30087A61F 2002/30677A61F 2002/3084A61F 2/3094A61F 2002/30971A61F 2310/00371A61F 2310/00293A61F 2310/00982A61L 27/24A61L 27/56A61L 27/52A61L 27/3834A61L 27/46A61L 2400/12
58
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Claims

Abstract

A scaffold comprised of a plurality of PLLA layers, which may include stem cells, for regenerating bone or tissue. The PLLA layers are separated by a plurality of hydrogel layers. The PLLA layers comprise a nanofiber mesh having a piezoelectric constant to apply an electrical charge to the bone or tissue upon application of ultrasound energy.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of regenerating bone or tissue, the method comprising:
 applying a scaffold to a wound, the scaffold comprising a plurality of PLLA layers, each layer separated by a hydrogel layer;   applying ultrasound energy to the scaffold;   generating an electrical surface charge on the scaffold; and   delivering an electrical output to the bone or tissue from the scaffold to regenerate the bone or tissue.   
     
     
         2 . The method of  claim 1 , wherein the ultrasound energy includes an intensity that is less than 0.5 W/cm 2 . 
     
     
         3 . The method of  claim 1 , wherein the ultrasound energy includes a frequency in the kHz range. 
     
     
         4 . The method of  claim 3 , wherein the ultrasound energy includes a frequency at 40 kHz. 
     
     
         5 . The method of  claim 1 , wherein at least one of the PLLA layers includes stem cells. 
     
     
         6 . The method of  claim 1 , wherein at least one of the PLLA layers includes growth factors. 
     
     
         7 . The method of  claim 6 , wherein the growth factors includes BMP-2. 
     
     
         8 . The method of  claim 1 , wherein the PLLA layers comprise a biodegradable nanofiber mesh. 
     
     
         9 . The method of  claim 8 , wherein the nanofiber mesh is created by an electrospinning process to exhibit piezoelectricity. 
     
     
         10 . The method of  claim 9 , wherein the electrospinning process rotates a collector drum at rotation speeds of between 1,000-4,000 rpm. 
     
     
         11 . The method of  claim 1 , wherein each PLLA layer includes a thickness of about 25 μm. 
     
     
         12 . The method of  claim 1 , wherein the scaffold includes about 2-10 PLLA layers. 
     
     
         13 . The method of  claim 1 , wherein at least one of the PLLA layers is bonded with a layer of collagen, loaded with calcium phosphate. 
     
     
         14 . The method of  claim 13 , wherein the calcium phosphate is tri-calcium phosphate. 
     
     
         15 . A scaffold for regenerating bone or tissue, the scaffold comprising:
 a plurality of PLLA layers comprising a nanofiber mesh, the PLLA layers having a piezo constant of 15-20 pC/N; and   a plurality of hydrogel layers, each hydrogel layer positioned between two PLLA layers;   wherein the plurality of PLLA layers deliver an electric charge to the bone or tissue after ultrasound energy is applied to the plurality of PLLA layers to induce growth of the bone or tissue.   
     
     
         16 . The scaffold of  claim 15 , wherein the plurality of PLLA layers includes 2-10 PLLA layers. 
     
     
         17 . The scaffold of  claim 15 , wherein at least one of the PLLA layers includes stem cells. 
     
     
         18 . The scaffold of  claim 15 , wherein at least one of the PLLA layers includes growth factors. 
     
     
         19 . The scaffold of  claim 18 , wherein the growth factors includes BMP-2. 
     
     
         20 . The scaffold of  claim 15 , wherein each PLLA layer includes a thickness of about 25 μm.

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