Composition for the prevention or treatment of respiratory diseases caused by fine dust comprising agastache rugosa and licorice extract

Abstract

The present invention relates to a composition for the prevention or treatment of respiratory diseases containing an Agastache rugosa and licorice extract as an active ingredient, and more specifically, the present invention relates to a composition for the prevention or treatment of respiratory diseases caused by fine dust containing an extract, in which Agastache rugosa and licorice are mixed at a weight ratio of 1:1 to 6:1, as an active ingredient. The Agastache rugosa and licorice extract of the present invention has the efficacies of reducing cough through inhibition of TRPV1 activity, reducing lung inflammation through inhibition of CXCR1 and CXCR2 activities and GR-1+CD11b+ cell ratio reduction, and suppressing sputum production through inhibition of MUC5AC activity. In particular, since it is confirmed that the efficacy of the Agastache rugosa and licorice complex mixture is maximized at a specific mixing ratio, it can be widely utilized as a composition for the prevention or treatment of respiratory diseases caused by fine dust.

1 .- 8 . (canceled) 
     
     
         9 . A pharmaceutical composition for preventing, ameliorating, or treating a respiratory disease, comprising an  Agastache rugosa  extract as an active ingredient. 
     
     
         10 . The pharmaceutical composition of  claim 9 , wherein the respiratory disease is induced by inhalation of fine dust and is one or more selected from the group consisting of respiratory inflammatory pulmonary disease, chronic obstructive pulmonary disease (COPD), sinusitis, allergic rhinitis, lower respiratory tract infection, acute and chronic bronchitis, emphysema, pneumonia, bronchial asthma, bronchiectasis, emphysema, pulmonary tuberculosis sequelae, acute respiratory distress syndrome, and pulmonary fibrosis. 
     
     
         11 . The pharmaceutical composition of  claim 9 , wherein the  Agastache rugosa  extract reduce cough through inhibition of TRPV1 activity, reduce lung inflammation through inhibition of CXCR1 or CXCR2 activity, or GR-1+CD11b+ cell ratio reduction, or suppress sputum production through inhibition of MUC5AC activity. 
     
     
         12 . A health functional food product for preventing or ameliorating a respiratory disease, comprising an  Agastache rugosa  extract. 
     
     
         13 . The health functional food product of  claim 12 , wherein the respiratory disease is induced by inhalation of fine dust and is one or more selected from the group consisting of respiratory inflammatory pulmonary disease, chronic obstructive pulmonary disease (COPD), sinusitis, allergic rhinitis, lower respiratory tract infection, acute and chronic bronchitis, emphysema, pneumonia, bronchial asthma, bronchiectasis, emphysema, pulmonary tuberculosis sequelae, acute respiratory distress syndrome, and pulmonary fibrosis. 
     
     
         14 . The health functional food product of  claim 12 , wherein the  Agastache rugosa  extract reduce cough through inhibition of TRPV1 activity, reduce lung inflammation through inhibition of CXCR1 or CXCR2 activity, or GR-1+CD11b+ cell ratio reduction, or suppress sputum production through inhibition of MUC5AC activity. 
     
     
         15 . A method for preventing, ameliorating, or treating a respiratory disease, comprising administering an  Agastache rugosa  extract to a subject in need thereof at an effective amount. 
     
     
         16 . The method of  claim 15 , wherein the respiratory disease is induced by inhalation of fine dust and is one or more selected from the group consisting of respiratory inflammatory pulmonary disease, chronic obstructive pulmonary disease (COPD), sinusitis, allergic rhinitis, lower respiratory tract infection, acute and chronic bronchitis, emphysema, pneumonia, bronchial asthma, bronchiectasis, emphysema, pulmonary tuberculosis sequelae, acute respiratory distress syndrome, and pulmonary fibrosis. 
     
     
         17 . The method of  claim 15 , wherein the  Agastache rugosa  extract reduce cough through inhibition of TRPV1 activity, reduce lung inflammation through inhibition of CXCR1 or CXCR2 activity, or GR-1+CD11b+ cell ratio reduction, or suppress sputum production through inhibition of MUC5AC activity. 
     
     
         18 . A method for producing the health functional food product for preventing or ameliorating a respiratory disease of  claim 12 , comprising preparing an  Agastache rugosa  extract; and making the health functional food product with the extract. 
     
     
         19 . The method of  claim 18 , wherein the respiratory disease is induced by inhalation of fine dust and is one or more selected from the group consisting of respiratory inflammatory pulmonary disease, chronic obstructive pulmonary disease (COPD), sinusitis, allergic rhinitis, lower respiratory tract infection, acute and chronic bronchitis, emphysema, pneumonia, bronchial asthma, bronchiectasis, emphysema, pulmonary tuberculosis sequelae, acute respiratory distress syndrome, and pulmonary fibrosis. 
     
     
         20 . The method of  claim 18 , wherein the  Agastache rugosa  extract reduce cough through inhibition of TRPV1 activity, reduce lung inflammation through inhibition of CXCR1 or CXCR2 activity, or GR-1+CD11b+ cell ratio reduction, or suppress sputum production through inhibition of MUC5AC activity.