Implantable endoluminal prosthesis

Abstract

The present disclosure refers to an implantable endoluminal prosthesis for use in the treatment of aneurysm involving branches having a multilayer configuration, comprising at least one self-expandable braided framework extending along an axis able to expand from a radially compressed state in a delivery configuration to a radially expanded state; the self-expandable braided framework being formed with at most 196 wires having a given wire diameter (ø 21 ); this self-expandable braided framework devoid of any impermeable cover layer, comprising a plurality of layers of wires made of biocompatible material; and forming a wall of the endoluminal prosthesis; each layer forming a mesh; the meshes forming a lattice with a plurality of wires of said layers; the meshes being interlocked, the wires being integrated in the mesh of at least one of the adjacent layers; the self-expandable braided framework comprising a lumen in a cylindrical form with a circular cross-section and a constant diameter; characterized in that, in radially expanded state, a ratio (T 1 /ø 21 ) of thickness (T 1 ) of a wall of the implantable endoluminal prosthesis in radially expanded state to the diameter (ø 21 ) of wire ( 21 ) being greater than 3.0; and the surface coverage ratio (SCR) of said braided framework is at least 30% and at most 50%.

1 . An implantable endoluminal prosthesis having an interlocked multilayer configuration, the implantable endoluminal prosthesis comprising:
 a self-expandable braided framework including a plurality of layers of wires made of a biocompatible material, the self-expandable braided framework extending along an axis and able to expand from a radially compressed state in a delivery configuration to a radially expanded state;   wherein:   each layer in the plurality of layers includes a plurality of wires having a given diameter and forming a mesh, wherein plies of the mesh are not distinct at the time of braiding, and a given number of wires of the plies of the first layer being interlocked with the plies of the second layer and/or other layers;   a surface coverage ratio (SCR) of the self-expandable braided framework in the radially expanded state is at least 30% and at most 50%%;   a ratio (T 1 /ø 21 ) of a thickness of a wall of the self-expandable braided framework, in the radially expanded state, to a diameter of the wire is greater than 2.0 and less than 3.0; and   wires of the interlocked multiple-layer configuration shift to keep a regular distance between adjacent parallel wires, resulting in that the SCR is maintained between a curved state and a straight configuration.   
     
     
         2 . The implantable endoluminal prosthesis according to  claim 1 , wherein the ratio (T 1 /ø 21 ) is at least 2.5. 
     
     
         3 . The implantable endoluminal prosthesis according to  claim 1 , wherein the SCR of said braided framework in the radially expanded state is at most 40%. 
     
     
         4 . The implantable endoluminal prosthesis according to  claim 1 , wherein the SCR of said braided framework in the radially expanded state is more than 35%. 
     
     
         5 . The implantable endoluminal prosthesis according to  claim 1 , wherein the self-expandable braided framework includes at least 90 wires and at most 130 wires. 
     
     
         6 . The implantable endoluminal prosthesis according to  claim 1 , wherein the biocompatible material is a metallic substrate selected from the group consisting of: titanium, a nickel-titanium alloy, a stainless steel, and a cobalt-chromium-nickel alloy. 
     
     
         7 . An implantable endoluminal prosthesis comprising:
 a plurality of wires having a given diameter and forming a self-expandable braided framework capable of being implanted into a lumen of a body vessel, wherein the self-expandable braided framework is delivered into the lumen in a radially compressed state and expands to a radially expanded state,   wherein:   the self-expandable braided framework includes multiple interlocked layers forming, in the radially expanded state, a porous wall, wherein plies of the multiple interlocked layers are not distinct at the time of braiding, and a given number of wires of the plies of the first layer being interlocked with the plies of the second layer and/or other layers;   the self-expandable braided framework, in the radially expanded state, has a surface coverage ratio (SCR) between 30% and 50%;   a ratio (T 1 /ø 21 ) of a thickness of a wall of the self-expandable braided framework, in the radially expanded state, to a diameter of the wire is greater than 2.0 and less than 3.0; and   the wires of the interlocked multiple-layer configuration shift to keep a regular distance between adjacent parallel wires, resulting in that the SCR is maintained between a curved state and a straight configuration.   
     
     
         8 . The implantable endoluminal prosthesis of  claim 7 , wherein a thickness of the porous wall is at least 2.5 times the diameter of each wire in the plurality of wires. 
     
     
         9 . The implantable endoluminal prosthesis according to  claim 7 , wherein the SCR of said braided framework in the radially expanded state is at most 40%. 
     
     
         10 . The implantable endoluminal prosthesis according to  claim 7 , wherein the SCR of said braided framework in the radially expanded state is more than 35%. 
     
     
         11 . The implantable endoluminal prosthesis of  claim 7 , wherein a total number of wires in the self-expandable braided framework is at least 90 wires and less than 130 wires. 
     
     
         12 . The implantable endoluminal prosthesis of  claim 7 , wherein the wires comprise a biocompatible metallic substrate selected from the group consisting of: stainless steel; nickel-titanium alloys; cobalt-chrome alloys; cobalt-chromium-nickel alloys; alloys of cobalt, nickel, chromium, and molybdenum; cobalt-chromium-vanadium alloys; cobalt-chromium-tungsten alloys; magnesium alloys; titanium alloys; and tantalum alloys.