US2023277444A1PendingUtilityA1
FORMULATIONS OF PTHrP ANALOGUES, TRANSDERMAL PATCHES THEREOF, AND USES THEREOF
Est. expiryOct 9, 2035(~9.2 yrs left)· nominal 20-yr term from priority
Inventors:Gary HattersleyAlan HarrisJamal SaehEhab HamedKenneth BrownDaniel DohmeierJoan T. MosemanYing ZhangLisa Dick
A61K 9/0021A61K 38/29A61K 47/02A61K 47/10A61K 47/40C07K 14/635A61K 9/08A61K 9/703A61K 38/00A61K 9/0014A61B 17/205A61B 2017/00526
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Claims
Abstract
Disclosed are PTHrP analogue formulations for transdermal delivery of a therapeutically effective amount of a PTHrP analogue, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.
Claims
exact text as granted — not AI-modified1 . A preparation formulation suitable for coating a transdermal patch wherein said preparation formulation comprises a therapeutically active substance, water and one or more excipients selected from the group consisting of Zn 2+ salts, Mg 2+ salts, Ca 2+ salts, polyethylene glycols and hydroxypropyl beta-cyclodextrins.
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