Phosphorylated Tri-Block Copolymers with Anti-Microbial Properties

Abstract

The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa , by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.

1 - 12 . (canceled) 
     
     
         13 . A method of producing the triblock copolymer comprising
 (a) covalently attaching at least two polyethylene glycol chains to a hydrophobic core comprising a carbocyclic or heterocyclic ring;   (b) covalently attaching at least two phosphate groups to at least one polyethylene glycol chain.   
     
     
         14 . The method of  claim 13  wherein at least two polyethylene glycol chains are each covalently attached to at least two phosphate groups. 
     
     
         15 - 26 . (canceled)