Compositions and methods for treating ophthalmic conditions

Abstract

The invention relates to compositions and methods for treating ophthalmic conditions.

1 - 116 . (canceled) 
     
     
         117 . A method of treating dry eye disease in a patient in need thereof, the method comprising topically administering to the patient a therapeutically effective amount of a compound of formula III or formula IV:
                       i, or                         or a pharmaceutically acceptable salt thereof.   
     
     
         118 . The method of  claim 117 , wherein the patient is a human patient. 
     
     
         119 . The method of  claim 117 , wherein the method comprises administering a therapeutically effective amount of a compound of formula III, or a pharmaceutically acceptable salt thereof. 
     
     
         120 . The method of  claim 117 , wherein the method comprises administering a therapeutically effective amount of a compound of formula IV, or a pharmaceutically acceptable salt thereof. 
     
     
         121 . The method of  claim 117 , wherein the dry eye disease is associated with ocular inflammation and/or pain associated with ocular surgery; with uveitis or conjunctivitis; with cystoid macular edema or diabetic retinopathy; with pterygium; or with mechanical trauma or chemical injury to the eye. 
     
     
         122 . The method of  claim 117 , wherein the method cures, ameliorates, stabilizes, and/or controls a symptom of dry eye disease. 
     
     
         123 . The method of  claim 117 , wherein the compound is administered to the patient in an eye drop dosage form. 
     
     
         124 . The method of  claim 117 , wherein the compound is administered to tissue surrounding an eye, to an eyelid, and/or to an eye of the patient. 
     
     
         125 . The method of  claim 117 , wherein the compound is administered about once per day to about 6 times per day. 
     
     
         126 . The method of  claim 125 , wherein the compound is administered once, twice or three times daily. 
     
     
         127 . The method of  claim 117 , wherein the administration continues for more than about 6, 10, 14, 28 days, two months, six months, or one year. 
     
     
         128 . The method of  claim 117 , wherein the compound is administered in an amount of 0.01 to 1000 mg per day. 
     
     
         129 . The method of  claim 117 , wherein the compound is administered in a pharmaceutical composition. 
     
     
         130 . The method of  claim 129 , wherein the pharmaceutical composition is formulated in a preparation in a solid, semi-solid, or liquid form. 
     
     
         131 . The method of  claim 130 , wherein the pharmaceutical composition is formulated as a gel, water soluble jelly, cream, lotion, suspension, foam, powder, slurry, ointment, solution, oil, paste, suppository, spray, emulsion, saline solution, or dimethylsulfoxide (DMSO)-based solution. 
     
     
         132 . The method of  claim 131 , wherein the pharmaceutical composition is formulated as a cream, ointment or spray.