Sauvignon blanc grape seed products for nonalcoholic fatty liver disease

Abstract

Embodiments described herein provide for uses of grape products, such as Chardonnay grape products and grape seed flour, for use in promoting a healthy liver, promoting healthy fat content in a liver, for treating or preventing NAFLD, and other embodiments and uses as described herein.

1 . A method of treating or preventing non-alcoholic fatty liver disease (NAFLD), reducing hepatic steatosis, reducing steatohepatitis, reducing hepatic fibrosis, or preventing non-alcoholic steatohepatitis (NASH) in a mammal comprising administering to the mammal an amount of a grape pomace effective to reduce, treat, or prevent NAFLD, hepatic steatosis, steatohepatitis, hepatic fibrosis, or NASH. 
     
     
         2 - 7 . (canceled) 
     
     
         8 . A method of reducing or preventing oxidative stress or lipid peroxidation in a mammal's liver comprising administering to the mammal an amount of a grape pomace effective to reduce or prevent oxidative stress or lipid peroxidation in the mammal's liver. 
     
     
         9 . (canceled) 
     
     
         10 . A method of protecting, supporting, enhancing, or maintaining cytochrome P450 and/or Phase II enzymatic detoxification system in a mammal's liver comprising administering to the mammal an amount of a grape pomace effective to protect, support, enhance, or maintain cytochrome P450 and/or Phase II enzymatic detoxification system in the mammal's liver. 
     
     
         11 - 22 . (canceled) 
     
     
         23 . The method of  claim 1 , wherein the grape pomace is administered in effective amount of about 1 mg to about 15,000 mg. 
     
     
         24 . The method of  claim 1 , wherein the mammal is a human, companion animal, domestic pet, husbanded animal, or livestock. 
     
     
         25 . The method of  claim 1 , wherein the method further comprises at least one additional compound. 
     
     
         26 . The method of  claim 25 , wherein the at least one additional compound is an antioxidant, an anti-cholesterol medication or compound, anti-glycemic compound, obeticholic acid, 2,4-dinitrophenol (DNP), DNP-methyl ether (DNPME), vitamin E, vitamin A, vitamin C, a carotenoid, lipoic acid, ubiquinol, ubiquinone, glutathione, s-adenosyl-methionine, trimethyl glycine, methionine, phosphatide, an essential fatty acid, choline, a B vitamin, a botanical or an extract thereof, or an insulin sensitizer. 
     
     
         27 - 30 . (canceled) 
     
     
         31 . The pharmaceutical composition of  claim 26 , wherein the botanical or an extract thereof, is milk thistle, schizandra, burdock, dandelion, artichoke, turmeric, celandine, kudzu, chicory, or yellow dock, or any extract thereof. 
     
     
         32 . The method of  claim 26 , wherein the anti-glycemic compound is an insulin sensitizer. 
     
     
         33 . The method of  claim 26 , wherein the insulin sensitizer is pioglitazone, metformin, sulfonylureas, or thiazolidinediones. 
     
     
         34 . The method of  claim 26 , wherein the anti-cholesterol compound is a HMG-CoA reductase inhibitor. 
     
     
         35 . The method of  claim 34 , wherein the HMG-CoA reductase inhibitor is atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, or simvastatin. 
     
     
         36 . The method of  claim 25 , wherein the grape pomace and the additional compound are administered in concurrently or in series. 
     
     
         37 . The method of  claim 25 , wherein the grape pomace and the additional compound are administered in the same formulation or in different formulations. 
     
     
         38 . The method of  claim 1 , wherein the mammal is on a high fat diet, comprising 30% to 50% fat by calorie content. 
     
     
         39 - 40 . (canceled) 
     
     
         41 . The method of  claim 1 , wherein the grape is a Chardonnay grape, a Cabernet Sauvignon grape, a Pinot Noir grape, a Sauvignon Blanc grape, or a White Riesling grape. 
     
     
         42 - 63 . (canceled)