Isotope-enriched 3-amino-1-propanesulfonic acid derivatives and uses thereof

Abstract

There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-β related diseases, such as Alzheimer's disease.R1R2X—CR2—CH2—CH2—SO3H  (I)

What is claimed is: 
     
         1 . A compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof:
   R 1 R 2 X—CR 2 —CH 2 —CH 2 —SO 3 H  (I)
   
       where:
 R 1  and R 2  are independently a hydrogen of natural abundance or a protecting group, wherein said protecting group is isotope-enriched or non-isotope enriched, said protecting group being selected from acyl, carbonyl, thiocarbonyl, and carbamoyl groups; 
 X is a nitrogen of natural abundance or  15 N, or a combination thereof, and 
 R is a hydrogen of natural abundance, a deuterium (D) or a combination thereof, 
 provided that at least one of X, R, R 1  and R 2  comprises an atom that is not of natural abundance. 
 
     
     
         2 .- 41 . (canceled)