Methods of administering intravenous meloxicam in a bolus dose

Abstract

The present disclosure relates to meloxicam bolus formulations and methods of administering the same intravenously, for treatment of pain, which can provide fast onset of pain relief suitable for management of acute moderate to severe pain.

1 . A method of treating pain in a patient in need thereof with meloxicam, (a) comprising administering to the patient a bolus dose of meloxicam intravenously, wherein the meloxicam is at a concentration of about 30 mg/mL. 
     
     
         2 . The method of  claim 1 , wherein the meloxicam is present as meloxicam nanocrystals. 
     
     
         3 . The method of  claim 1 , wherein the bolus dose of meloxicam is administered to the patient over the course of about 1 to about 60 seconds. 
     
     
         4 . The method of  claim 1 , wherein the dose of meloxicam is administered to the patient over the course of about 5 to about 45 seconds. 
     
     
         5 . The method of  claim 1 , wherein the dose of meloxicam is administered to the patient over the course of about 15 to about 30 seconds. 
     
     
         6 . The method of  claim 1 , wherein the dose of meloxicam is in the range of from about 15 mg to about 180 mg. 
     
     
         7 . The method of  claim 1 , any one of  claims 1   6 , wherein the dose of meloxicam is about 30 mg. 
     
     
         8 . The method of  claim 1 , wherein the dose of meloxicam is about 60 mg. 
     
     
         9 . The method of  claim 1 , wherein the dose of meloxicam is present in a volume of from about 0.5 mL to about 4 mL. 
     
     
         10 . The method of  claim 1 , wherein the dose of meloxicam is present in a volume of about 1 mL. 
     
     
         11 . The method of  claim 1 , wherein the pain is post-surgical pain. 
     
     
         12 . The method of  claim 1 , wherein the dose of meloxicam is administered after the patient has undergone a surgical procedure. 
     
     
         13 . The method of  claim 12 , wherein the surgical procedure is an open surgical procedure. 
     
     
         14 . The method of  claim 12 , wherein the surgical procedure is a laparoscopic surgical procedure. 
     
     
         15 . The method of  claim 12 , wherein the surgical procedure was performed on hard tissue. 
     
     
         16 . The method of  claim 12 , wherein the surgical procedure was performed on soft tissue. 
     
     
         17 . The method of  claim 1 , wherein the pain is moderate to severe pain. 
     
     
         18 . The method of  claim 1 , wherein the pain is mild to moderate pain. 
     
     
         19 . The method of  claim 1 , further comprising administering meloxicam to the patient about every 16 hours to about every 26 hours after step (a), and until the patient is no longer in need thereof 
     
     
         20 . The method of  claim 1 , wherein meloxicam is administered to the patient about 18 hours to about every 24 hours after step (a), and until the patient is no longer in need thereof