US2023302195A1PendingUtilityA1

Hydrogel composition for mucosal lifting procedures within lumenal anatomical structures

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Assignee: QMARK MEDICAL INCPriority: Dec 21, 2018Filed: May 5, 2023Published: Sep 28, 2023
Est. expiryDec 21, 2038(~12.4 yrs left)· nominal 20-yr term from priority
Inventors:Patrick H. RuaneSameer Sharma
A61L 27/20A61K 31/738A61L 27/16A61L 27/18A61L 27/52A61L 27/54A61L 31/14A61L 31/041A61L 27/26A61L 2300/442A61L 2400/06A61L 27/50A61K 31/78A61L 31/145
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Claims

Abstract

An injectable medical composition includes an acrylate and a solvent. The composition has a first viscosity at temperatures below body temperature and a second viscosity at body temperature. The first viscosity is lower than the second viscosity.

Claims

exact text as granted — not AI-modified
1 . An injectable medical composition comprising:
 an acrylate and a solvent;   wherein the composition has a first viscosity at temperatures below a body temperature from 35.5° C.-38.5° C. and a second viscosity when exposed to the body temperature, the first viscosity lower than the second viscosity.   
     
     
         2 . The composition of  claim 1 , wherein, 15 minutes after exposure to the body temperature, has a third viscosity that is 50% or more of the second viscosity. 
     
     
         3 . The composition of  claim 1 , wherein the composition, at 90 minutes after exposure to the body temperature, has a fourth viscosity that is less than the second viscosity and the first viscosity. 
     
     
         4 . The composition of  claim 3 , wherein the fourth viscosity is less than 100 mPa·s. 
     
     
         5 . The composition of  claim 1 , wherein the second viscosity is from 2500 mPa·s to 20000 mPa·s at the body temperature. 
     
     
         6 . The composition of  claim 1 , wherein the acrylate comprises a poly(acrylic acid) copolymer. 
     
     
         7 . The composition of  claim 6 , wherein the poly(acrylic acid) copolymer in the composition is between 0.2% and 5% w/v. 
     
     
         8 . The composition of  claim 6 , wherein the poly(acrylic acid) copolymer comprises allyl sucrose or allyl pentaerythritol. 
     
     
         9 . The composition of  claim 6 , wherein the composition further comprises poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide). 
     
     
         10 . The composition of  claim 1 , wherein a hardness of the composition at the body temperature is between 1N and 10N. 
     
     
         11 . The composition of  claim 1 , wherein a compressibility of the composition at the body temperature is less than 10N.

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