Modulation of gene expression in a human bioreactor

Abstract

A method is provided for treating a recipient with a biological product obtained from at least one donor that may be the same as, or different from, the recipient. The method includes identifying a targeted level of gene expression of a first gene in a biological product to be transferred from at least one donor to a recipient; treating the at least one donor to achieve the targeted level of gene expression of the first gene in the biological product; and transferring the biological product from the at least one donor to the recipient.

101 . A method for treating a recipient, comprising:
 obtaining portions of a biological product from each of a plurality of donors, wherein each portion of the biological product is characterized by a level of a first targeted gene expression;   determining a desired level of the first targeted gene expression in a derived product to be derived from the obtained portions of the biological product;   forming the derived product by creating a mixture of the obtained portions of the biological product having the desired level of the first targeted gene expression; and
 administering the derived product to the recipient.