Methods of treating a latent hiv-1 infection using non-coding deoxyribonucleic acids

Abstract

The invention relates to a non-coding sequence of deoxyribonucleic acids comprising at least one sequence motif N 1 N 2 CGN 3 N 4 , wherein N is a nucleotide comprising A, C, T, or G, and C is deoxycytidine, G is deoxyguanosine, A is deoxyadenosine and T is deoxythymidine for the treatment of viral infections. In particular, the non-coding sequence of deoxyribonucleic acids is used in combination with antiretroviral therapy and/or histone de-acetylase inhibitors.

1 .- 21 . (canceled) 
     
     
         22 . A method of treating a viral infection in a patient in need thereof, comprising administering to the patient a non-coding sequence of deoxyribonucleic acids comprising CCTAGGGGTT ACCACCTTCA TTGGAAAACG TTCTTCGGGG CGTTCTTAGG TGGTAACC CCTAGGGGTT ACCACCTTCA TTGGAAAACG TTCTTCGGGG CGTTCTTAGG TGGTAACC (SEQ ID NO:5). 
     
     
         23 . The method of  claim 22 , wherein the viral infection is a latent infection. 
     
     
         24 . The method of  claim 22 , wherein the viral infection is a retroviral infection. 
     
     
         25 . The method of  claim 24 , wherein the viral infection is a latent infection. 
     
     
         26 . The method of  claim 22 , wherein the viral infection is an HIV-1 infection. 
     
     
         27 . The method of  claim 26 , wherein the viral infection is a latent infection. 
     
     
         28 . The method of  claim 22 , wherein the non-coding sequence of deoxyribonucleic acids has a length of up to 200 nucleotides. 
     
     
         29 . The method of  claim 22 , wherein the non-coding sequence of deoxyribonucleic acids has a length of 116 nucleotides. 
     
     
         30 . The method of  claim 22 , wherein the non-coding sequence of deoxyribonucleic acids is administered in combination with combination antiretroviral therapy. 
     
     
         31 . The method of  claim 30 , wherein the non-coding sequence of deoxyribonucleic acids is administered simultaneously with combination antiretroviral therapy. 
     
     
         32 . The method of  claim 30 , wherein the non-coding sequence of deoxyribonucleic acids is administered alternating with combination antiretroviral therapy. 
     
     
         33 . The method of  claim 30 , wherein the non-coding sequence of deoxyribonucleic acids is administered successively with combination antiretroviral therapy.