Methods of treating gastric infections, gastroenteritis, and wounds

Abstract

The present invention is directed to a method and a composition for producing and using a plant-based biocidal solution. The plant-based biocidal solution contains a bioactive material and a plant-based substance formed from the cellular material of a plant. The plant-based substance is capable of binding to the bioactive material. In some embodiments, the bioactive material is hydrogen peroxide. The hydrogen peroxide can be added exogenously or generated endogenously. In accordance with further embodiments, the plant-based biocidal solution can be applied to a target, thereby impairing the target. In some embodiments, the target can be a pathogen. In accordance with another embodiment, the plant-based substance of the plant-based biocidal solution can form a microscopic cluster, a complex, or an aggregate for providing sufficient bioactive material to overcome the defense mechanism of the target.

We claim: 
     
         1 . A method of treating a gastric infection in a subject, the method comprising: administering to the subject an ingestible dosage form having hydrogen peroxide with an increased half-life, the dosage form comprising:
 an effective amount of a combination of an ingestible, water-soluble polyphenol as an extract from a plant,-wherein the extract has been inactivated to substantially inactivate hydrogen peroxide degrading enzymes;   
       and,
 (ii) hydrogen peroxide, wherein the hydrogen peroxide was added to the extract after the extract was inactivated to substantially inactivate the hydrogen peroxide degrading enzymes; 
 
       wherein,
 the ingestible, water-soluble polyphenol is bound to the hydrogen peroxide in the combination; 
 the administering treats the gastric infection in the subject; and 
 the ingestible, water-soluble polyphenol increases the half-life of the hydrogen peroxide in the ingestible dosage form, the stability of the hydrogen peroxide in the combination being greater in an aqueous solution than the stability of the hydrogen peroxide alone in the aqueous solution. 
 
     
     
         2 . The method of  claim 1 , wherein the dosage form comprises 1% of hydrogen peroxide. 
     
     
         3 . The method of  claim 1 , wherein the dosage form comprises 0.05% to 3% of hydrogen peroxide. 
     
     
         4 . The method form of  claim 1 , wherein the dosage form comprises 0.02% of hydrogen peroxide. 
     
     
         5 . The method of  claim 1 , wherein the dosage form is provided in a solid form, the solid form being more compact and stable than an aqueous solution of the extract and the hydrogen peroxide. 
     
     
         6 . The method of  claim 1 , wherein the combination of the polyphenol and hydrogen peroxide is a biocide. 
     
     
         7 . The method of  claim 1 , wherein the combination of the polyphenol and hydrogen peroxide is a mycocide. 
     
     
         8 . A method of treating gastroentenitis in a subject, the mthod comprising:
 administering to the sunject an ingestable dosage form having hydrogen peroxide with an increased half-life, the dosgae form comprising:   an effective amount of a combination of   (i) an ingestible, water-soluble polyphenol as an extract from a plant, wherein the extract has been inactivated to substantially inactivate hydrogen peroxide degrading enzymes;   
       and,
 (ii) hydrogen peroxide, wherein the hydrogen peroxide was added to the extract after the extract was inactivated to substantially inactivate the hydrogen peroxide degrading enzymes; 
 
       wherein,
 the ingestible, water-soluble polyphenol is bound to the hydrogen peroxide in the combination; 
 the administering treats gastroenteritis in the subject; and, 
 the ingestible, water-soluble polyphenol increases the half-life of the hydrogen peroxide in the ingestible dosage form, the stability of the hydrogen peroxide in the combination being greater in an aqueous solution than the stability of the hydrogen peroxide alone in the aqueous solution. 
 
     
     
         9 . The method of  claim 8 , wherein the dosage form comprises 1% of hydrogen peroxide. 
     
     
         10 . The method of  claim 8 , wherein the dosage form 0.05% to 3% of hydrogen peroxide. 
     
     
         11 . The method of  claim 8 , wherein the dosage form comprises 0.02% of hydrogen peroxide. 
     
     
         12 . The method of  claim 8 , wherein the dosage form is provided in a solid form, the solid form being more compact and stable than an aqueous solution of the extract and the hydrogen peroxide. 
     
     
         13 . A method of treating wounds in a subject, the method comprising:
 administering to the subject a dosage form having hydrogen peroxide with an increased half-life, the dosage form comprising:   an effective amount of combination of   (i) an ingestible, water-soluble polyphenol as an extract from a plant, wherein the extract has been inactivated to substanitially inactivate hydrogen peroxide degrading enzymes;   
       and,
 (ii) hydrogen peroxide, wherein the hydrogen peroxide was added to the extract after the extract was inactivated to substanitially inactivate the hydrogen peroxide degrading enzymes; 
 
       wherein
 the ingestible, water-soluble polyphenol is bound to the hydrogen peroxide in the combination; 
 the administering benefits wound healing in the subject; and 
 the ingestible, water-soluble polyphenol increases the half-life of the hydrogen peroxide in the ingestible dosage form, the stability of the hydrogen peroxide in the combination being greater in an aqueous solution than the stability of the hydrogen peroxide alone in the aqueous solution. 
 
     
     
         14 . The method pf  claim 13 , wherein the dosage form comprises 1% of hydrogen peroxide. 
     
     
         15 . The method of  claim 13 , wherein the dosage form comprises 0.05% to 3% of hydrogen and peroxide. 
     
     
         16 . The method form of  claim 13 , wherein the dosage form comprises 0.02% of hydrogen peroxide. 
     
     
         17 . The method of  claim 13 , wherein the dosage form is provided in a solid form, the solid form being more compact and stable than an aqueous solution of the extract and the hydrogen peroxide. 
     
     
         18 . The method of  claim 13 , wherein the wound healing includes exudate control. 
     
     
         19 . The method of  claim 13 , wherein the wound healing includes wound closure. 
     
     
         20 . The method of  claim 13 , wherein the would healing includes rapid scab formation.