US2023322878A1PendingUtilityA1
Compounds for inducing tissue formation and uses thereof
Est. expiryAug 25, 2035(~9.1 yrs left)· nominal 20-yr term from priority
Inventors:Omar F. Zouani
C07K 14/51C07K 2299/00A61L 27/227C07K 14/475A61P 11/00A61P 11/06A61P 13/12A61P 15/00A61P 17/14A61P 19/00A61P 19/02A61P 19/06A61P 21/00A61P 21/02A61P 25/00A61P 27/02A61P 29/00A61P 3/04A61P 31/04A61P 31/06A61P 43/00A61P 7/02A61P 7/06A61P 9/00A61P 9/04A61P 9/06A61P 9/10A61P 9/12A61K 8/64A61K 38/16A61Q 5/002A61Q 7/00
47
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
The present disclosure provides peptides, or variants or analogs thereof, with between 8 and 30 amino acids, having growth factor receptor-binding capability, wherein the RMSD value of the structure coordinates of said peptide, variant or analog thereof with respect to PEPREF is 2.45 Å (Angstroms) or less.
Claims
exact text as granted — not AI-modified1 - 100 . (canceled)
101 . A peptide that is up to 30 amino acids in length and that comprises a peptide with four amino acids, PEP1;
wherein PEP1 is selected from the group consisting of SAIS, NAIS and SPIS, wherein the RMSD value of the structure coordinates of said peptide or peptidomimetic with respect to PEPREF is 2.45 Å (Angstroms) or less; and wherein PEPREF is
ATOM
511
N
LYS
A
1
−14.570
46.437
27.424
ATOM
512
CA
LYS
A
1
−13.512
45.748
28.151
ATOM
513
C
LYS
A
1
−13.655
44.259
27.884
ATOM
514
O
LYS
A
1
−12.769
43.463
28.197
ATOM
515
CB
LYS
A
1
−13.605
46.029
29.652
ATOM
516
CG
LYS
A
1
−13.640
47.509
29.991
ATOM
517
CD
LYS
A
1
−12.615
48.297
29.183
ATOM
518
CE
LYS
A
1
−12.625
49.768
29.575
ATOM
519
NZ
LYS
A
1
−13.994
50.369
29.497
ATOM
520
N
ILE
A
2
−14.792
43.890
27.309
ATOM
521
CA
ILE
A
2
−15.051
42.499
26.967
ATOM
522
C
ILE
A
2
−14.911
42.370
25.444
ATOM
523
O
ILE
A
2
−15.531
43.125
24.683
ATOM
524
CB
ILE
A
2
−16.466
42.065
27.401
ATOM
525
CG1
ILE
A
2
−16.630
42.238
28.915
ATOM
526
CG2
ILE
A
2
−16.710
40.629
26.985
ATOM
527
CD1
ILE
A
2
−15.631
41.478
29.30
ATOM
528
N
PRO
A
3
−14.085
41.411
24.989
ATOM
529
CA
PRO
A
3
−13.789
41.109
23.588
ATOM
530
C
PRO
A
3
−14.998
40.695
22.768
ATOM
531
O
PRO
A
3
−15.969
40.164
23.305
ATOM
532
CB
PRO
A
3
−12.785
39.968
23.688
ATOM
533
CG
PRO
A
3
−12.156
40.166
25.007
ATOM
534
CD
PRO
A
3
−13.330
40.506
25.867
ATOM
535
N
LYS
A
4
−14.937
40.937
21.463
ATOM
536
CA
LYS
A
4
−16.023
40.529
20.590
ATOM
537
C
LYS
A
4
−15.886
39.015
20.391
ATOM
538
O
LYS
A
4
−14.903
38.415
20.831
ATOM
539
CB
LYS
A
4
−15.926
41.244
19.245
ATOM
540
CG
LYS
A
4
−15.802
42.751
19.355
ATOM
541
CD
LYS
A
4
−16.292
43.433
18.083
ATOM
542
CE
LYS
A
4
−16.162
44.943
18.177
ATOM
543
NZ
LYS
A
4
−16.825
45.628
17.019
ATOM
544
N
ALA
A
5
−16.85
38.393
19.759
ATOM
545
CA
ALA
A
5
−16.811
36.955
19.507
ATOM
546
C
ALA
A
5
−15.772
36.771
18.416
ATOM
547
O
ALA
A
5
−15.727
37.534
17.455
ATOM
548
CB
ALA
A
5
−18.168
36.419
19.043
ATOM
549
N
CYS
A
6
−14.935
35.756
18.562
ATOM
550
CA
CYS
A
6
−13.887
35.518
17.584
ATOM
551
C
CYS
A
6
−14.347
34.765
16.338
ATOM
552
O
CYS
A
6
−15.327
34.018
16.368
ATOM
553
CB
CYS
A
6
−12.743
34.768
18.241
ATOM
554
SG
CYS
A
6
−11.198
34.959
17.353
ATOM
555
N
CYS
A
7
−13.623
34.973
15.243
ATOM
556
CA
CYS
A
7
−13.931
34.328
13.969
ATOM
557
C
CYS
A
7
−13.091
33.071
13.798
ATOM
558
O
CYS
A
7
−11.961
33.123
13.302
ATOM
559
CB
CYS
A
7
−13.653
35.290
12.824
ATOM
560
SG
CYS
A
7
−13.930
34.633
11.154
ATOM
561
N
VAL
A
8
−13.654
31.941
14.209
ATOM
562
CA
VAL
A
8
−12.949
30.684
14.110
ATOM
563
C
VAL
A
8
−13.653
29.733
13.157
ATOM
564
O
VAL
A
8
−14.759
30.016
12.687
ATOM
565
CB
VAL
A
8
−12.814
30.038
15.492
ATOM
566
CG1
VAL
A
8
−11.807
30.825
16.337
ATOM
567
CG2
VAL
A
8
−14.161
30.006
16.170
ATOM
568
N
PRO
A
9
−13.003
28.601
12.828
ATOM
569
CA
PRO
A
9
−13.593
27.615
11.918
ATOM
570
C
PRO
A
9
−14.726
26.886
12.631
ATOM
571
O
PRO
A
9
−14.581
26.476
13.780
ATOM
572
CB
PRO
A
9
−12.423
26.676
11.601
ATOM
573
CG
PRO
A
9
−11.204
27.487
11.925
ATOM
574
CD
PRO
A
9
−11.620
28.226
13.163
ATOM
575
N
THR
A
10
−15.847
26.721
11.942
ATOM
576
CA
THR
A
10
−16.999
26.060
12.527
ATOM
577
C
THR
A
10
−17.334
24.767
11.804
ATOM
578
O
THR
A
10
−18.097
23.943
12.303
ATOM
579
CB
THR
A
10
−18.211
27.010
12.523
ATOM
580
OG1
THR
A
10
−18.491
27.445
11.185
ATOM
581
CG2
THR
A
10
−17.902
28.230
13.375
ATOM
582
N
GLU
A
11
−16.750
24.586
10.627
ATOM
583
CA
GLU
A
11
−16.980
23.377
9.848
ATOM
584
C
GLU
A
11
−15.643
22.935
9.246
ATOM
585
O
GLU
A
11
−15.029
23.666
8.464
ATOM
586
CB
GLU
A
11
−17.981
23.624
8.715
ATOM
587
CG
GLU
A
11
−19.421
23.807
9.163
ATOM
588
CD
GLU
A
11
−19.686
25.166
9.770
ATOM
589
OE1
GLU
A
11
−19.478
26.175
9.073
ATOM
590
OE2
GLU
A
11
−20.111
25.227
10.939
ATOM
591
N
LEU
A
12
−15.183
21.749
9.622
ATOM
592
CA
LEU
A
12
−13.923
21.254
9.104
ATOM
593
C
LEU
A
12
−14.062
19.912
8.386
ATOM
594
O
LEU
A
12
−15.136
19.299
8.359
ATOM
595
CB
LEU
A
12
−12.893
21.144
10.230
ATOM
596
CG
LEU
A
12
−12.660
22.422
11.054
ATOM
597
CD1
LEU
A
12
−13.475
22.350
12.337
ATOM
598
CD2
LEU
A
12
−11.181
22.586
11.399
ATOM
599
N
SER
A
13
−12.971
19.476
7.771
ATOM
600
CA
SER
A
13
−12.964
18.218
7.046
ATOM
601
C
SER
A
13
−11.568
17.628
7.164
ATOM
602
O
SER
A
13
−10.613
18.320
7.550
ATOM
603
CB
SER
A
13
−13.346
18.435
5.578
ATOM
604
OG
SER
A
13
−12.404
19.261
4.923
ATOM
605
N
ALA
A
13
−11.449
16.352
6.818
ATOM
606
CA
ALA
A
13
−10.179
15.665
6.949
ATOM
607
C
ALA
A
13
−9.421
15.471
5.652
ATOM
608
O
ALA
A
13
−9.941
15.720
4.563
ATOM
609
CB
ALA
A
13
−10.413
14.306
7.626
ATOM
610
N
ILE
A
14
−8.171
15.046
5.783
ATOM
611
CA
ILE
A
14
−7.343
14.746
4.623
ATOM
612
C
ILE
A
14
−6.475
13.559
5.004
ATOM
613
O
ILE
A
14
−6.212
13.316
6.183
ATOM
614
CB
ILE
A
14
−6.401
15.916
4.183
ATOM
615
CG1
ILE
A
14
−5.284
16.106
5.200
ATOM
616
CG2
ILE
A
14
−7.188
17.211
3.982
ATOM
617
CD1
ILE
A
14
−4.173
16.973
4.696
ATOM
618
N
SER
A
15
−6.045
12.806
3.999
ATOM
619
CA
SER
A
15
−5.187
11.662
4.242
ATOM
620
C
SER
A
15
−3.740
12.089
4.217
ATOM
621
O
SER
A
15
−3.360
13.020
3.508
ATOM
622
CB
SER
A
15
−5.416
10.584
3.185
ATOM
623
OG
SER
A
15
−6.667
9.971
3.401
ATOM
624
N
MET
A
16
−2.933
11.409
5.012
ATOM
625
CA
MET
A
16
−1.518
11.700
5.047
ATOM
626
C
MET
A
16
−0.778
10.414
5.244
ATOM
627
O
MET
A
16
−1.137
9.594
6.078
ATOM
628
CB
MET
A
16
−1.170
12.694
6.164
ATOM
629
CG
MET
A
16
−1.848
14.042
5.974
ATOM
630
SD
MET
A
16
−1.017
15.431
6.760
ATOM
631
CE
MET
A
16
−0.799
14.823
8.475
ATOM
632
N
LEU
A
17
0.238
10.231
4.426
ATOM
633
CA
LEU
A
17
1.077
9.065
4.508
ATOM
634
C
LEU
A
17
2.289
9.610
5.264
ATOM
635
O
LEU
A
17
2.939
10.565
4.818
ATOM
636
CB
LEU
A
17
1.461
8.608
3.100
ATOM
637
CG
LEU
A
17
2.324
7.355
2.955
ATOM
638
CD1
LEU
A
17
1.553
6.145
3.445
ATOM
639
CD2
LEU
A
17
2.723
7.190
1.492
ATOM
640
N
TYR
A
18
2.581
9.029
6.418
ATOM
641
CA
TYR
A
18
3.706
9.501
7.196
ATOM
642
C
TYR
A
18
4.434
8.333
7.835
ATOM
643
O
TYR
A
18
4.081
7.186
7.603
ATOM
644
CB
TYR
A
18
3.222
10.458
8.281
ATOM
645
CG
TYR
A
18
2.386
9.782
9.346
ATOM
646
CD1
TYR
A
18
1.029
9.527
9.147
ATOM
647
CD2
TYR
A
18
2.961
9.379
10.550
ATOM
648
CE1
TYR
A
18
0.273
8.894
10.128
ATOM
649
CE2
TYR
A
18
2.218
8.745
11.526
ATOM
650
CZ
TYR
A
18
0.877
8.508
11.317
ATOM
651
OH
TYR
A
18
0.134
7.922
12.318
ATOM
652
N
LEU
A
19
5.439
8.651
8.650
ATOM
653
CA
LEU
A
19
6.255
7.661
9.347
ATOM
654
C
LEU
A
19
6.210
7.946
10.847
ATOM
655
O
LEU
A
19
6.685
8.992
11.288
ATOM
656
CB
LEU
A
19
7.701
7.763
8.871
ATOM
657
CG
LEU
A
19
7.901
7.850
7.359
ATOM
658
CD1
LEU
A
19
9.300
8.379
7.039
ATOM
659
CD2
LEU
A
19
7.669
6.482
6.748
102 . The peptide of claim 101 , that comprises a peptide PEP9, wherein the pair PEP9:PEP1 is selected from the group consisting of GIPEPXXVPTKM (SEQ ID NO: 6493):SAIS (SEQ ID NO: 6360), HVTKPTXVPTKL (SEQ ID NO: 6519):SAIS (SEQ ID NO: 6360), YVPKPXXVPTKL (SEQ ID NO: 6589):SAIS (SEQ ID NO: 6360), TVPKPXXVPTQL (SEQ ID NO: 6581):SAIS (SEQ ID NO: 6360), AVPKAXXVPTKL (SEQ ID NO: 6485):SAIS (SEQ ID NO: 6360), KVGKAXXVPTKL (SEQ ID NO: 6543):SAIS (SEQ ID NO: 6360), KASKAXXVPTKL (SEQ ID NO: 6527):SAIS (SEQ ID NO: 6360), GSAGPXXVPTKM (SEQ ID NO: 6501):SAIS (SEQ ID NO: 6360), AAPASXXVPTRL (SEQ ID NO: 6461):SAIS (SEQ ID NO: 6360), STPPTXXVPTRL (SEQ ID NO: 6573):SAIS (SEQ ID NO: 6360), HVPKPXXVPTKL (SEQ ID NO: 6509):SAIS (SEQ ID NO: 6360), RVPSTXXVPTKT (SEQ ID NO: 6555):SAIS (SEQ ID NO: 6360), ASAAPXXVPTAL (SEQ ID NO: 6469):SAIS (SEQ ID NO: 6360), ASASPXXVPTDL (SEQ ID NO: 6477):SAIS (SEQ ID NO: 6360), GIPEPXXVPEKM (SEQ ID NO: 6491):SAIS (SEQ ID NO: 6360), HVTKPTXAPTKL (SEQ ID NO: 6511):SAIS (SEQ ID NO: 6360), YVPKPXXAPTKL (SEQ ID NO: 6583):SAIS (SEQ ID NO: 6360), TVPKPXXAPTQL (SEQ ID NO: 6575):SAIS (SEQ ID NO: 6360), AVPKAXXAPTKL (SEQ ID NO: 6479):SAIS (SEQ ID NO: 6360), GSAGPXXTPTKM (SEQ ID NO: 6497):SAIS (SEQ ID NO: 6360), AAPASXXVPARL (SEQ ID NO: 6458):SAIS (SEQ ID NO: 6360), HVPKPXXAPTKL (SEQ ID NO: 6503):SAIS (SEQ ID NO: 6360), RVPSTXXAPVKT (SEQ ID NO: 6550):SAIS (SEQ ID NO: 6360), ASAAPXXVPQAL (SEQ ID NO: 6468):SAIS (SEQ ID NO: 6360), ASASPXXVSQDL (SEQ ID NO: 6478):SAIS (SEQ ID NO: 6360), ASASPXXVPQDL (SEQ ID NO: 6476):SAIS (SEQ ID NO: 6360), SSVKXQPSRVHH (SEQ ID NO: 6565):SAIS (SEQ ID NO: 6360), RNVQXRPTQVQL (SEQ ID NO: 6548):SAIS (SEQ ID NO: 6360), KIPKAXXAPTEL (SEQ ID NO: 6529):NAIS (SEQ ID NO: 6357), GIPEPXXAPTKM (SEQ ID NO: 6487):NAIS (SEQ ID NO: 6357), SIPKAXXAPTEL (SEQ ID NO: 6557):NAIS (SEQ ID NO: 6357), AVPKAXXAPTKL (SEQ ID NO: 6479):NAIS (SEQ ID NO: 6357), KVGKAXXAPTKL (SEQ ID NO: 6537):NAIS (SEQ ID NO: 6357), KASKAXXAPTKL (SEQ ID NO: 6521):NAIS (SEQ ID NO: 6357), GSAGPXXAPTKM (SEQ ID NO: 6495):NAIS (SEQ ID NO: 6357), AAPASXXAPTRL (SEQ ID NO: 6455):NAIS (SEQ ID NO: 6357), STPPTXXAPTRL (SEQ ID NO: 6567):NAIS (SEQ ID NO: 6357), RVPSTXXAPTKT (SEQ ID NO: 6549):NAIS (SEQ ID NO: 6357), ASAAPXXAPTAL (SEQ ID NO: 6463):NAIS (SEQ ID NO: 6357), ASASPXXAPTDL (SEQ ID NO: 6471):NAIS (SEQ ID NO: 6357), KIPKAXXVPTEL (SEQ ID NO: 6535):NAIS (SEQ ID NO: 6357), GIPEPXXVPEKM (SEQ ID NO: 6491):NAIS (SEQ ID NO: 6357), SIPKAXXVPTEL (SEQ ID NO: 6563):NAIS (SEQ ID NO: 6357), KVGKAXXVPTKL (SEQ ID NO: 6543):NAIS (SEQ ID NO: 6357), KASKAXXVPTKL (SEQ ID NO: 6527):NAIS (SEQ ID NO: 6357), GSAGPXXTPTKM (SEQ ID NO: 6497):NAIS (SEQ ID NO: 6357), AAPASXXVPARL (SEQ ID NO: 6458):NAIS (SEQ ID NO: 6357), STPPTXXVPTRL (SEQ ID NO: 6573):NAIS (SEQ ID NO: 6357), RVPSTXXAPVKT (SEQ ID NO: 6550):NAIS (SEQ ID NO: 6357), ASAAPXXVPQAL (SEQ ID NO: 6468):NAIS (SEQ ID NO: 6357), ASASPXXVSQDL (SEQ ID NO: 6478):NAIS (SEQ ID NO: 6357), ASASPXXVPQDL (SEQ ID NO: 6476):NAIS (SEQ ID NO: 6357), NDEGLEXVPTEE (SEQ ID NO: 6545):NAIS (SEQ ID NO: 6357), NDEGLEXVPTGQ (SEQ ID NO: 6546):NAIS (SEQ ID NO: 6357), SSVKXQPSRVHH (SEQ ID NO: 6565):NAIS (SEQ ID NO: 6357), RNVQXRPTQVQL (SEQ ID NO: 6548):NAIS (SEQ ID NO: 6357), KIPKAXXVPTEL (SEQ ID NO: 6535):SPIS (SEQ ID NO: 6364), GIPEPXXVPTKM (SEQ ID NO: 6493):SPIS (SEQ ID NO: 6364), SIPKAXXVPTEL (SEQ ID NO: 6563):SPIS (SEQ ID NO: 6364), HVTKPTXVPTKL (SEQ ID NO: 6519):SPIS (SEQ ID NO: 6364), YVPKPXXVPTKL (SEQ ID NO: 6589):SPIS (SEQ ID NO: 6364), TVPKPXXVPTQL (SEQ ID NO: 6581):SPIS (SEQ ID NO: 6364), AVPKAXXVPTKL (SEQ ID NO: 6485):SPIS (SEQ ID NO: 6364), KASKAXXVPTKL (SEQ ID NO: 6527):SPIS (SEQ ID NO: 6364), GSAGPXXVPTKM (SEQ ID NO: 6501):SPIS (SEQ ID NO: 6364), AAPASXXVPTRL (SEQ ID NO: 6461):SPIS (SEQ ID NO: 6364), STPPTXXVPTRL (SEQ ID NO: 6573):SPIS (SEQ ID NO: 6364), HVPKPXXVPTKL (SEQ ID NO: 6509):SPIS (SEQ ID NO: 6364), RVPSTXXVPTKT (SEQ ID NO: 6555):SPIS (SEQ ID NO: 6364), ASAAPXXVPTAL (SEQ ID NO: 6469):SPIS (SEQ ID NO: 6364), ASASPXXVPTDL (SEQ ID NO: 6477):SPIS (SEQ ID NO: 6364), GIPEPXXVPEKM (SEQ ID NO: 6491):SPIS (SEQ ID NO: 6364), HVTKPTXAPTKL (SEQ ID NO: 6511):SPIS (SEQ ID NO: 6364), YVPKPXXAPTKL (SEQ ID NO: 6583):SPIS (SEQ ID NO: 6364), TVPKPXXAPTQL (SEQ ID NO: 6575):SPIS (SEQ ID NO: 6364), AVPKAXXAPTKL (SEQ ID NO: 6479):SPIS (SEQ ID NO: 6364), GSAGPXXTPTKM (SEQ ID NO: 6497):SPIS (SEQ ID NO: 6364), AAPASXXVPARL (SEQ ID NO: 6458):SPIS (SEQ ID NO: 6364), HVPKPXXAPTKL (SEQ ID NO: 6503):SPIS (SEQ ID NO: 6364), RVPSTXXAPVKT (SEQ ID NO: 6550):SPIS (SEQ ID NO: 6364), ASAAPXXVPQAL (SEQ ID NO: 6468):SPIS (SEQ ID NO: 6364), ASASPXXVSQDL (SEQ ID NO: 6478):SPIS (SEQ ID NO: 6364), ASASPXXVPQDL (SEQ ID NO: 6476):SPIS (SEQ ID NO: 6364), SSVKXQPSRVHH (SEQ ID NO: 6565):SPIS (SEQ ID NO: 6364), RNVQXRPTQVQL (SEQ ID NO: 6548):SPIS (SEQ ID NO: 6364), and wherein X is C or S.
103 . The peptide of claim 101 , wherein PEP1 is selected from the group consisting of SAIS, NAIS and SPIS and said peptide comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 5, 8, 11, 12, 14 to 23, 25 to 35, 43, 44, 45, 46, 47, 48, 49, 85, 86, 95 to 102, 105 to 123, 155 to 181, 208 to 234, 293 to 352, 506, 507, 510, 511, 514, 515, 520, 521, 522, 523, 1071, 1074, 1076, 1077, 1144, 1145, 1147, 1154, 1155, 1158, 1159, 1162, 1163, 1181, 1182, 1183, 1185, 1186, 1188, 1189, 1190, 1191, 1194, 1196, 1199 to 1206, 1208 to 1215, 1218, 1221, 1223, 1224, 1227, 1228, 1229, 1230, 1231, 1232, 1233, 1235, 1236, 1237, 1238, 1240, 1241, 1243, 1244, 1245, 1246, 1248, 1249, 1250, 1251, 1252, 1253, 1254, 1256, 1260 to 1270, 1272, 1273, 1274, 1275, 1276, 1279, 1280, 1282, 1283, 1285 to 1303, 1306, 1307, 1309, 1310, 1311, 1312, 1314 to 1325, 1328, 1329, 1332, 1333, 1339 to 1349, 1351, 1352, 1353, 1354, 1355, 1356, 1358, 1359, 1360, 1361, 1362, 1363, 1365, 1368, 1369, 1370, 1371, 1372, 1374, 1375, 1376, 1377, 1379, 1382 to 1391, 1394 to 1407, 1409, 1411, 1412, 1415, 1417, 1418, 1419, 1421, 1423, 1424, 1426, 1427, 1428, 1429, 1430, 1431, 1432, 1434, 1436, 1439, 1440, 1443, 1445, 1446, 1448, 1449, 1450, 1451, 1452, 1453, 1454, 1455, 1456, 1457, 1459, 1461, 1465, 1467, 1468, 1470, 1472 to 1482, 1484, 1485, 1487, 1489, 1490, 1870, 1871, 1872, 1873, 1877, 1880, 1882, 1884, 1885, 1886, 1888, 1889, 1890, 1896, 1897, 1900, 1901, 1902, 1904, 1907, 1909, 1913, 1916, 1917, 1919, 1920, 1922, 1926, 1929, 1931, 1933, 1936, 1937, 1940, 1941, 1942, 1943, 1946, 1947, 1948, 1950, 1951, 1956, 1957, 1958, 1959, 1960, 1961, 1964, 1965, 1967, 1968, 1969, 1972, 1973, 1974, 1975, 1976, 1980, 1985, 1986, 1987, 1989, 1991, 1992, 1994, 1995, 2000, 2001, 2002, 2003, 2005, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2015, 2016, 2019, 2020, 2023, 2024, 2025, 2028 to 2044, 2047, 2049, 2050, 2051, 2055, 2057, 2058, 2060, 2061, 2062, 2063, 2064, 2066, 2069, 2071, 2072, 2073, 2074, 2079, 2082, 2083, 2084, 2085, 2086, 2087, 2088, 2089, 2092, 2093, 2094, 2096, 2097, 2099, 2100, 2102, 2103, 2105, 2106, 2108, 2109, 2110, 2111, 2113, 2115, 2116, 2119, 2121 to 2130, 2132, 2137, 2138, 2140, 2142, 2145, 2146, 2147, 2148, 2149, 2150, 2154, 2156, 2157, 2158, 2159, 2160, 2161, 2163, 2164, 2165, 2166, 2167, 2168, 2170, 2172, 2178, 2179, 2180, 2181, 2182, 2183, 2191, 2192, 2195, 2197, 2198, 2199, 2200, 2808, 2809, 2810, 2811, 2812, 2814, 2817, 2819, 2824, 2825, 2826, 2827, 2828, 2829, 2831, 2833, 2835, 2837, 2838, 2839, 2841, 2843, 2846, 2849, 2853, 2855, 2856, 2858, 2860, 2862, 2863, 2864, 2865, 2867, 2869, 2870, 2871, 2872, 2873, 2875, 2876, 2879, 2880, 2881, 2883 to 2891, 2895, 2896, 2897, 2899, 2900, 2901, 2904 to 2911, 2913 to 2920, 2922, 2923, 2925, 2926, 2927, 2928, 2929, 2931, 2933, 2934, 2935, 2936, 2938, 2940, 2941, 2942, 2944, 2946, 2947, 2949, 2953, 2954, 2960, 2962 to 2968, 2970, 2971, 2973, 2974, 2975, 2976, 2979, 2980, 2981, 2983, 2984, 2985, 2986, 2987, 2988, 2990 to 3002, 3004 to 3010, 3012 to 3020, 3022, 3023, 3026, 3029, 3030, 3031, 3032, 3033, 3034, 3035, 3037, 3038, 3039, 3041 to 3049, 3051, 3052, 3053, 3054, 3055, 3056, 3057, 3059 to 3071, 3073, 3074, 3075, 3077, 3079, 3080, 3081, 3083, 3085, 3087, 3089, 3090, 3092 to 3099, 3101, 3103 to 3112, 3114, 3116, 3118, 3119, 3120, 3121, 3122, 3124 to 3132, 3134, 3135, 3136, 3137, 3139 to 3151, 3153, 3154, 3155, 3156, 3158, 3159, 3160, 3162, 3164, 3363 to 3424, 3429, 3430, 3432, 3438, 3439, 3441, 3443, 3444, 3445, 3446, 3447, 3448, 3452, 3455, 3456, 3457, 3458, 3459, 3460, 3463, 3465, 3467, 3472, 3474, 3481, 3482, 3483, 3484, 3487, 3490, 3491, 3493, 3495, 3496, 3497, 3499, 3502, 3506, 3508, 3510, 3513, 3514, 3515, 3518, 3519, 3523, 3525, 3526, 3527, 3528, 3529, 3532, 3533, 3534, 3537, 3539, 3540, 3541, 3542, 3543, 3547, 3548, 3550, 3554 to 3563, 3567, 3568, 3569, 3572, 3573, 3574, 3575, 3576, 3579, 3581, 3583, 3585, 3587, 3588, 3593, 3595, 3597, 3599, 3602, 3603, 3605, 3606, 3607, 3609, 3613, 3614, 3615, 3616, 3617, 3625, 3626, 3627, 3628, 3629, 3631, 3632, 3634, 3635, 3636, 3637, 3638, 3640, 3642, 3643, 3644, 3645, 3646, 3647, 3648, 3652, 3653, 3654, 3655, 3656, 3659, 3661, 3662, 3664, 3671 to 3684, 3688, 3690, 3691, 3692, 3696, 3697, 3704, 3707, 3708, 3710, 3711, 3713, 3714, 3715, 3716, 3718, 3719, 3720, 4527 to 4607, 4721, 4723, 4725, 4732, 4736, 4738, 4739, 4740, 4742, 4746, 4751, 4753, 4756, 4757, 4759, 4765, 4771, 4774, 4781, 4785, 4789, 4791, 4799, 4806, 4808, 4810, 4814, 4816, 4822, 4823, 4824, 4825, 4827, 4828, 4829, 4830, 4832, 4834, 4836, 4840, 4842, 4843, 4847, 4850, 4856, 4858, 4860, 4864, 4880, 4881, 4882, 4886, 4887, 4888, 4891, 4893, 4894, 4895, 4899, 4900, 4902, 4909, 4910, 4911, 4915, 4916, 4919, 4920, 4921, 4924, 4925, 4929, 4931, 4933, 4935, 4937, 4941, 4943, 4944, 4945, 4948, 4949, 4950, 4955, 4956, 4957, 4959, 4960, 4961, 4963, 4964, 4966, 4967, 4970, 4971, 4972, 4973, 4974, 4977, 4978, 4986, 4990, 4993, 4994, 4995, 4999, 5002, 5005, 5006, 5009, 5010, 5015, 5016, 5017, 5019, 5023, 5024, 5026, 5031, 5033, 5034, 5035, 5038, 5042, 5044, 5047, 5049, 5050, 5056, 5058, 5059, 5062, 5065, 5067, 5069, 5070, 5073, 5078, 5082, 5085, 5088, 5092, 5099, 5101, 5105, 5108, 5109, 5112, 5114, 5118, 5122, 5123, 5127, 5128, 5129, 5131, 5132, 5133, 5134, 5137, 5140, 5142, 5147, 5150, 5153, 5154, 5157, 5158, 5160, 5164, 5165, 5167, 5169, 5170, 5171, 5175, 5182, 5185, 5187, 5189, 5191, 5192, 5193, 5197, 5198, 5199, 5201, 5202, 5205, 5207, 5210, 5211, 5212, 5214, 5218, 5220, 5222, 5223, 5225, 5229, 5231, 5233, 5237, 5241, 5242, 5244, 5247, 5250, 5254, 5255, 5257, 5258, 5260, 5261, 5262, 5263, 5265, 5270, 5280, 5288, 5290, 5291, 5293, 5294, 5295, 5299, 5304, 5305, 5306, 5307, 5308, 5310, 5314, 5316, 5318, 5325, 5329, 5337, 5339, 5340, 5343, 5344, 5346, 5353, 5358, 5360, 5361, 5362, 5366, 5369, 5370, 5372, 5374, 5375, 5376, 5379, 5380, 5381, 5384, 5385, 5386, 5393, 5397, and 5645 to 5909.
104 . The peptide of claim 101 , that comprises a peptide PEP9, wherein PEP1 is SAIS and wherein the pair PEP9:PEP1 is selected from the group consisting of GIPEPXXVPTKM (SEQ ID NO: 6493):SAIS (SEQ ID NO: 6360), HVTKPTXVPTKL (SEQ ID NO: 6519):SAIS (SEQ ID NO: 6360), YVPKPXXVPTKL (SEQ ID NO: 6589):SAIS (SEQ ID NO: 6360), TVPKPXXVPTQL (SEQ ID NO: 6581):SAIS (SEQ ID NO: 6360), AVPKAXXVPTKL (SEQ ID NO: 6485):SAIS (SEQ ID NO: 6360), KVGKAXXVPTKL (SEQ ID NO: 6543):SAIS (SEQ ID NO: 6360), KASKAXXVPTKL (SEQ ID NO: 6527):SAIS (SEQ ID NO: 6360), GSAGPXXVPTKM (SEQ ID NO: 6501):SAIS (SEQ ID NO: 6360), AAPASXXVPTRL (SEQ ID NO: 6461):SAIS (SEQ ID NO: 6360), STPPTXXVPTRL (SEQ ID NO: 6573):SAIS (SEQ ID NO: 6360), HVPKPXXVPTKL (SEQ ID NO: 6509):SAIS (SEQ ID NO: 6360), RVPSTXXVPTKT (SEQ ID NO: 6555):SAIS (SEQ ID NO: 6360), ASAAPXXVPTAL (SEQ ID NO: 6469):SAIS (SEQ ID NO: 6360), ASASPXXVPTDL (SEQ ID NO: 6477):SAIS (SEQ ID NO: 6360), GIPEPXXVPEKM (SEQ ID NO: 6491):SAIS (SEQ ID NO: 6360), HVTKPTXAPTKL (SEQ ID NO: 6511):SAIS (SEQ ID NO: 6360), YVPKPXXAPTKL (SEQ ID NO: 6583):SAIS (SEQ ID NO: 6360), TVPKPXXAPTQL (SEQ ID NO: 6575):SAIS (SEQ ID NO: 6360), AVPKAXXAPTKL (SEQ ID NO: 6479):SAIS (SEQ ID NO: 6360), GSAGPXXTPTKM (SEQ ID NO: 6497):SAIS (SEQ ID NO: 6360), AAPASXXVPARL (SEQ ID NO: 6458):SAIS (SEQ ID NO: 6360), HVPKPXXAPTKL (SEQ ID NO: 6503):SAIS (SEQ ID NO: 6360), RVPSTXXAPVKT (SEQ ID NO: 6550):SAIS (SEQ ID NO: 6360), ASAAPXXVPQAL (SEQ ID NO: 6468):SAIS (SEQ ID NO: 6360), ASASPXXVSQDL (SEQ ID NO: 6478):SAIS (SEQ ID NO: 6360), ASASPXXVPQDL (SEQ ID NO: 6476):SAIS (SEQ ID NO: 6360), SSVKXQPSRVHH (SEQ ID NO: 6565):SAIS (SEQ ID NO: 6360) and RNVQXRPTQVQL (SEQ ID NO: 6548):SAIS (SEQ ID NO: 6360),
105 . The peptide of claim 101 , wherein PEP1 is SAIS and said peptide comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 1, 2, 3, 12, 14, 15, 18 to 23, 26, 27, 28, 33, 34, 35, 95, 96, 102, 105 to 123, 506, 507, 1071, 1144, 1154, 1155, 1181, 1182, 1188, 1190, 1191, 1199, 1202, 1203, 1205, 1206, 1208, 1211, 1212, 1213, 1214, 1229, 1230, 1231, 1235, 1236, 1238, 1243, 1244, 1248, 1252, 1256, 1262, 1263, 1268, 1272, 1275, 1286, 1288, 1291, 1292, 1294, 1295, 1296, 1299, 1300, 1302, 1306, 1307, 1309, 1310, 1311, 1316, 1317, 1319, 1320, 1333, 1345, 1347, 1349, 1354, 1358, 1359, 1361, 1363, 1368, 1369, 1370, 1371, 1374, 1376, 1379, 1382, 1384, 1390, 1391, 1397, 1399, 1401, 1402, 1426, 1428, 1430, 1445, 1449, 1451, 1453, 1476, 1479, 1484, 1487, 1871, 1877, 1882, 1884, 1885, 1902, 1904, 1909, 1916, 1917, 1926, 1936, 1943, 1946, 1964, 1965, 1969, 1974, 1975, 1976, 1985, 1987, 1994, 2002, 2012, 2016, 2019, 2028, 2030, 2032, 2034, 2038, 2039, 2041, 2042, 2049, 2055, 2060, 2061, 2066, 2073, 2082, 2083, 2084, 2086, 2094, 2096, 2099, 2100, 2102, 2103, 2105, 2109, 2110, 2116, 2119, 2123, 2125, 2126, 2145, 2147, 2148, 2150, 2158, 2160, 2163, 2164, 2166, 2181, 2183, 2192, 2198, 5646, 5648, 5649, 5650, 5653, 5654, 5659, 5660, 5661, 5663, 5664, 5667, 5668, 5671, 5672, 5673, 5674, 5675, 5676, 5680, 5683, 5684, 5685, 5686, 5687, 5689, 5693, 5694, 5696, 5699, 5700, 5701, 5702, 5705, 5706, 5707, 5710, 5713, 5714, 5715, 5716, 5718, 5719, 5721, 5722, 5724, 5725, 5726, 5729, 5730, 5732, 5733, 5734, 5735, 5736, 5737, 5742, 5744, 5748, 5751, 5752, 5753, 5754, 5758, 5760, 5763, 5764, 5766, 5767, 5771, 5774, 5775, 5776, 5779, 5780, 5783, 5785, 5786, 5787, 5788, 5789, 5792, 5793, 5794, 5795, 5796, 5798, 5799, 5800, 5804, 5807, 5808, 5809, 5811, 5817, 5819, 5822, 5823, 5825, 5827, 5828, 5831, 5832, 5836, 5837, 5839, 5840, 5841, 5842, 5845, 5846, 5851, 5856, 5859, 5860, 5866, 5867, 5868, 5871, 5873, 5874, 5875, 5877, 5878, 5881, 5883, 5884, 5885, 5886, 5891, 5892, 5894, 5896, 5897, 5898, 5899, 5901, 5903, 5904, 5906, and 5907.
106 . The peptide of claim 101 , wherein the peptide is up to 25 amino acids in length.
107 . A peptide that is up to 30 amino acids in length and that comprises: the amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 5, 8, 11, 12, 14 to 23, 25 to 35, 43, 44, 45, 46, 47, 48, 49, 85, 86, 95 to 102, 105 to 123, 155 to 181, 208 to 234, 293 to 352, 506, 507, 510, 511, 514, 515, 520, 521, 522, 523, 1071, 1074, 1076, 1077, 1144, 1145, 1147, 1154, 1155, 1158, 1159, 1162, 1163, 1181, 1182, 1183, 1185, 1186, 1188, 1189, 1190, 1191, 1194, 1196, 1199 to 1206, 1208 to 1215, 1218, 1221, 1223, 1224, 1227, 1228, 1229, 1230, 1231, 1232, 1233, 1235, 1236, 1237, 1238, 1240, 1241, 1243, 1244, 1245, 1246, 1248, 1249, 1250, 1251, 1252, 1253, 1254, 1256, 1260 to 1270, 1272, 1273, 1274, 1275, 1276, 1279, 1280, 1282, 1283, 1285 to 1303, 1306, 1307, 1309, 1310, 1311, 1312, 1314 to 1325, 1328, 1329, 1332, 1333, 1339 to 1349, 1351, 1352, 1353, 1354, 1355, 1356, 1358, 1359, 1360, 1361, 1362, 1363, 1365, 1368, 1369, 1370, 1371, 1372, 1374, 1375, 1376, 1377, 1379, 1382 to 1391, 1394 to 1407, 1409, 1411, 1412, 1415, 1417, 1418, 1419, 1421, 1423, 1424, 1426, 1427, 1428, 1429, 1430, 1431, 1432, 1434, 1436, 1439, 1440, 1443, 1445, 1446, 1448, 1449, 1450, 1451, 1452, 1453, 1454, 1455, 1456, 1457, 1459, 1461, 1465, 1467, 1468, 1470, 1472 to 1482, 1484, 1485, 1487, 1489, 1490, 1870, 1871, 1872, 1873, 1877, 1880, 1882, 1884, 1885, 1886, 1888, 1889, 1890, 1896, 1897, 1900, 1901, 1902, 1904, 1907, 1909, 1913, 1916, 1917, 1919, 1920, 1922, 1926, 1929, 1931, 1933, 1936, 1937, 1940, 1941, 1942, 1943, 1946, 1947, 1948, 1950, 1951, 1956, 1957, 1958, 1959, 1960, 1961, 1964, 1965, 1967, 1968, 1969, 1972, 1973, 1974, 1975, 1976, 1980, 1985, 1986, 1987, 1989, 1991, 1992, 1994, 1995, 2000, 2001, 2002, 2003, 2005, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2015, 2016, 2019, 2020, 2023, 2024, 2025, 2028 to 2044, 2047, 2049, 2050, 2051, 2055, 2057, 2058, 2060, 2061, 2062, 2063, 2064, 2066, 2069, 2071, 2072, 2073, 2074, 2079, 2082, 2083, 2084, 2085, 2086, 2087, 2088, 2089, 2092, 2093, 2094, 2096, 2097, 2099, 2100, 2102, 2103, 2105, 2106, 2108, 2109, 2110, 2111, 2113, 2115, 2116, 2119, 2121 to 2130, 2132, 2137, 2138, 2140, 2142, 2145, 2146, 2147, 2148, 2149, 2150, 2154, 2156, 2157, 2158, 2159, 2160, 2161, 2163, 2164, 2165, 2166, 2167, 2168, 2170, 2172, 2178, 2179, 2180, 2181, 2182, 2183, 2191, 2192, 2195, 2197, 2198, 2199, 2200, 2808, 2809, 2810, 2811, 2812, 2814, 2817, 2819, 2824, 2825, 2826, 2827, 2828, 2829, 2831, 2833, 2835, 2837, 2838, 2839, 2841, 2843, 2846, 2849, 2853, 2855, 2856, 2858, 2860, 2862, 2863, 2864, 2865, 2867, 2869, 2870, 2871, 2872, 2873, 2875, 2876, 2879, 2880, 2881, 2883 to 2891, 2895, 2896, 2897, 2899, 2900, 2901, 2904 to 2911, 2913 to 2920, 2922, 2923, 2925, 2926, 2927, 2928, 2929, 2931, 2933, 2934, 2935, 2936, 2938, 2940, 2941, 2942, 2944, 2946, 2947, 2949, 2953, 2954, 2960, 2962 to 2968, 2970, 2971, 2973, 2974, 2975, 2976, 2979, 2980, 2981, 2983, 2984, 2985, 2986, 2987, 2988, 2990 to 3002, 3004 to 3010, 3012 to 3020, 3022, 3023, 3026, 3029, 3030, 3031, 3032, 3033, 3034, 3035, 3037, 3038, 3039, 3041 to 3049, 3051, 3052, 3053, 3054, 3055, 3056, 3057, 3059 to 3071, 3073, 3074, 3075, 3077, 3079, 3080, 3081, 3083, 3085, 3087, 3089, 3090, 3092 to 3099, 3101, 3103 to 3112, 3114, 3116, 3118, 3119, 3120, 3121, 3122, 3124 to 3132, 3134, 3135, 3136, 3137, 3139 to 3151, 3153, 3154, 3155, 3156, 3158, 3159, 3160, 3162, 3164, 3363 to 3424, 3429, 3430, 3432, 3438, 3439, 3441, 3443, 3444, 3445, 3446, 3447, 3448, 3452, 3455, 3456, 3457, 3458, 3459, 3460, 3463, 3465, 3467, 3472, 3474, 3481, 3482, 3483, 3484, 3487, 3490, 3491, 3493, 3495, 3496, 3497, 3499, 3502, 3506, 3508, 3510, 3513, 3514, 3515, 3518, 3519, 3523, 3525, 3526, 3527, 3528, 3529, 3532, 3533, 3534, 3537, 3539, 3540, 3541, 3542, 3543, 3547, 3548, 3550, 3554 to 3563, 3567, 3568, 3569, 3572, 3573, 3574, 3575, 3576, 3579, 3581, 3583, 3585, 3587, 3588, 3593, 3595, 3597, 3599, 3602, 3603, 3605, 3606, 3607, 3609, 3613, 3614, 3615, 3616, 3617, 3625, 3626, 3627, 3628, 3629, 3631, 3632, 3634, 3635, 3636, 3637, 3638, 3640, 3642, 3643, 3644, 3645, 3646, 3647, 3648, 3652, 3653, 3654, 3655, 3656, 3659, 3661, 3662, 3664, 3671 to 3684, 3688, 3690, 3691, 3692, 3696, 3697, 3704, 3707, 3708, 3710, 3711, 3713, 3714, 3715, 3716, 3718, 3719, 3720, 4527 to 4607, 4721, 4723, 4725, 4732, 4736, 4738, 4739, 4740, 4742, 4746, 4751, 4753, 4756, 4757, 4759, 4765, 4771, 4774, 4781, 4785, 4789, 4791, 4799, 4806, 4808, 4810, 4814, 4816, 4822, 4823, 4824, 4825, 4827, 4828, 4829, 4830, 4832, 4834, 4836, 4840, 4842, 4843, 4847, 4850, 4856, 4858, 4860, 4864, 4880, 4881, 4882, 4886, 4887, 4888, 4891, 4893, 4894, 4895, 4899, 4900, 4902, 4909, 4910, 4911, 4915, 4916, 4919, 4920, 4921, 4924, 4925, 4929, 4931, 4933, 4935, 4937, 4941, 4943, 4944, 4945, 4948, 4949, 4950, 4955, 4956, 4957, 4959, 4960, 4961, 4963, 4964, 4966, 4967, 4970, 4971, 4972, 4973, 4974, 4977, 4978, 4986, 4990, 4993, 4994, 4995, 4999, 5002, 5005, 5006, 5009, 5010, 5015, 5016, 5017, 5019, 5023, 5024, 5026, 5031, 5033, 5034, 5035, 5038, 5042, 5044, 5047, 5049, 5050, 5056, 5058, 5059, 5062, 5065, 5067, 5069, 5070, 5073, 5078, 5082, 5085, 5088, 5092, 5099, 5101, 5105, 5108, 5109, 5112, 5114, 5118, 5122, 5123, 5127, 5128, 5129, 5131, 5132, 5133, 5134, 5137, 5140, 5142, 5147, 5150, 5153, 5154, 5157, 5158, 5160, 5164, 5165, 5167, 5169, 5170, 5171, 5175, 5182, 5185, 5187, 5189, 5191, 5192, 5193, 5197, 5198, 5199, 5201, 5202, 5205, 5207, 5210, 5211, 5212, 5214, 5218, 5220, 5222, 5223, 5225, 5229, 5231, 5233, 5237, 5241, 5242, 5244, 5247, 5250, 5254, 5255, 5257, 5258, 5260, 5261, 5262, 5263, 5265, 5270, 5280, 5288, 5290, 5291, 5293, 5294, 5295, 5299, 5304, 5305, 5306, 5307, 5308, 5310, 5314, 5316, 5318, 5325, 5329, 5337, 5339, 5340, 5343, 5344, 5346, 5353, 5358, 5360, 5361, 5362, 5366, 5369, 5370, 5372, 5374, 5375, 5376, 5379, 5380, 5381, 5384, 5385, 5386, 5393, 5397, and 5645 to 5909; and
at least one biomaterial-affinity-containing group, wherein said at least one biomaterial-affinity-containing group provides said peptide, with the ability to covalently or non-covalently interact with a biomaterial.
108 . A functionalized biomaterial comprising at least one peptide according to claim 101 , and a biomaterial.
109 . A medical composition comprising at least one peptide according to claim 101 , and a medically acceptable carrier.
110 . A medical composition comprising at least one peptide according to claim 107 , and a medically acceptable carrier.
111 . A medical composition comprising at least one functionalized biomaterial according to claim 108 , and a medically acceptable carrier.
112 . A functionalized biomaterial according to claim 108 , wherein said biomaterial has a stiffness of at least 0.01 kPa and not more than 5 GPa.
113 . A functionalized biomaterial according to claim 108 , wherein said biomaterial is selected from the group consisting of metals and alloys, ceramics, polymeric biomaterials, and biocomposite materials.
114 . A functionalized biomaterial according to claim 108 , wherein said biomaterial is selected from the group consisting of a solid ceramic component, a collagen and a biodegradable hydrogel.
115 . A method of inducing cell differentiation, tissue regeneration, or tissue formation comprising:
administering an effective amount of a peptide to a mesenchymal stem cell or progenitor cell at any stage of differentiation thereof, wherein said method is selected from the group consisting of a pharmaceutical method, a surgical method, a dermatological method, a prophylactic method, an imaging method and any combination thereof, wherein the administration is in vitro, ex vivo or in vivo, and wherein the peptide is up to 30 amino acids in length and comprises a peptide with four amino acids, PEP1; wherein PEP1 is selected from the group consisting of SAIS, NAIS and SPIS; wherein the RMSD value of the structure coordinates of said peptide or peptidomimetic with respect to PEPREF is 2.45 Å (Angstroms) or less; and wherein PEPREF is
ATOM
511
N
LYS
A
1
−14.570
46.437
27.424
ATOM
512
CA
LYS
A
1
−13.512
45.748
28.151
ATOM
513
C
LYS
A
1
−13.655
44.259
27.884
ATOM
514
O
LYS
A
1
−12.769
43.463
28.197
ATOM
515
CB
LYS
A
1
−13.605
46.029
29.652
ATOM
516
CG
LYS
A
1
−13.640
47.509
29.991
ATOM
517
CD
LYS
A
1
−12.615
48.297
29.183
ATOM
518
CE
LYS
A
1
−12.625
49.768
29.575
ATOM
519
NZ
LYS
A
1
−13.994
50.369
29.497
ATOM
520
N
ILE
A
2
−14.792
43.890
27.309
ATOM
521
CA
ILE
A
2
−15.051
42.499
26.967
ATOM
522
C
ILE
A
2
−14.911
42.370
25.444
ATOM
523
O
ILE
A
2
−15.531
43.125
24.683
ATOM
524
CB
ILE
A
2
−16.466
42.065
27.401
ATOM
525
CG1
ILE
A
2
−16.630
42.238
28.915
ATOM
526
CG2
ILE
A
2
−16.710
40.629
26.985
ATOM
527
CD1
ILE
A
2
−15.631
41.478
29.30
ATOM
528
N
PRO
A
3
−14.085
41.411
24.989
ATOM
529
CA
PRO
A
3
−13.789
41.109
23.588
ATOM
530
C
PRO
A
3
−14.998
40.695
22.768
ATOM
531
O
PRO
A
3
−15.969
40.164
23.305
ATOM
532
CB
PRO
A
3
−12.785
39.968
23.688
ATOM
533
CG
PRO
A
3
−12.156
40.166
25.007
ATOM
534
CD
PRO
A
3
−13.330
40.506
25.867
ATOM
535
N
LYS
A
4
−14.937
40.937
21.463
ATOM
536
CA
LYS
A
4
−16.023
40.529
20.590
ATOM
537
C
LYS
A
4
−15.886
39.015
20.391
ATOM
538
O
LYS
A
4
−14.903
38.415
20.831
ATOM
539
CB
LYS
A
4
−15.926
41.244
19.245
ATOM
540
CG
LYS
A
4
−15.802
42.751
19.355
ATOM
541
CD
LYS
A
4
−16.292
43.433
18.083
ATOM
542
CE
LYS
A
4
−16.162
44.943
18.177
ATOM
543
NZ
LYS
A
4
−16.825
45.628
17.019
ATOM
544
N
ALA
A
5
−16.85
38.393
19.759
ATOM
545
CA
ALA
A
5
−16.811
36.955
19.507
ATOM
546
C
ALA
A
5
−15.772
36.771
18.416
ATOM
547
O
ALA
A
5
−15.727
37.534
17.455
ATOM
548
CB
ALA
A
5
−18.168
36.419
19.043
ATOM
549
N
CYS
A
6
−14.935
35.756
18.562
ATOM
550
CA
CYS
A
6
−13.887
35.518
17.584
ATOM
551
C
CYS
A
6
−14.347
34.765
16.338
ATOM
552
O
CYS
A
6
−15.327
34.018
16.368
ATOM
553
CB
CYS
A
6
−12.743
34.768
18.241
ATOM
554
SG
CYS
A
6
−11.198
34.959
17.353
ATOM
555
N
CYS
A
7
−13.623
34.973
15.243
ATOM
556
CA
CYS
A
7
−13.931
34.328
13.969
ATOM
557
C
CYS
A
7
−13.091
33.071
13.798
ATOM
558
O
CYS
A
7
−11.961
33.123
13.302
ATOM
559
CB
CYS
A
7
−13.653
35.290
12.824
ATOM
560
SG
CYS
A
7
−13.930
34.633
11.154
ATOM
561
N
VAL
A
8
−13.654
31.941
14.209
ATOM
562
CA
VAL
A
8
−12.949
30.684
14.110
ATOM
563
C
VAL
A
8
−13.653
29.733
13.157
ATOM
564
O
VAL
A
8
−14.759
30.016
12.687
ATOM
565
CB
VAL
A
8
−12.814
30.038
15.492
ATOM
566
CG1
VAL
A
8
−11.807
30.825
16.337
ATOM
567
CG2
VAL
A
8
−14.161
30.006
16.170
ATOM
568
N
PRO
A
9
−13.003
28.601
12.828
ATOM
569
CA
PRO
A
9
−13.593
27.615
11.918
ATOM
570
C
PRO
A
9
−14.726
26.886
12.631
ATOM
571
O
PRO
A
9
−14.581
26.476
13.780
ATOM
572
CB
PRO
A
9
−12.423
26.676
11.601
ATOM
573
CG
PRO
A
9
−11.204
27.487
11.925
ATOM
574
CD
PRO
A
9
−11.620
28.226
13.163
ATOM
575
N
THR
A
10
−15.847
26.721
11.942
ATOM
576
CA
THR
A
10
−16.999
26.060
12.527
ATOM
577
C
THR
A
10
−17.334
24.767
11.804
ATOM
578
O
THR
A
10
−18.097
23.943
12.303
ATOM
579
CB
THR
A
10
−18.211
27.010
12.523
ATOM
580
OG1
THR
A
10
−18.491
27.445
11.185
ATOM
581
CG2
THR
A
10
−17.902
28.230
13.375
ATOM
582
N
GLU
A
11
−16.750
24.586
10.627
ATOM
583
CA
GLU
A
11
−16.980
23.377
9.848
ATOM
584
C
GLU
A
11
−15.643
22.935
9.246
ATOM
585
O
GLU
A
11
−15.029
23.666
8.464
ATOM
586
CB
GLU
A
11
−17.981
23.624
8.715
ATOM
587
CG
GLU
A
11
−19.421
23.807
9.163
ATOM
588
CD
GLU
A
11
−19.686
25.166
9.770
ATOM
589
OE1
GLU
A
11
−19.478
26.175
9.073
ATOM
590
OE2
GLU
A
11
−20.111
25.227
10.939
ATOM
591
N
LEU
A
12
−15.183
21.749
9.622
ATOM
592
CA
LEU
A
12
−13.923
21.254
9.104
ATOM
593
C
LEU
A
12
−14.062
19.912
8.386
ATOM
594
O
LEU
A
12
−15.136
19.299
8.359
ATOM
595
CB
LEU
A
12
−12.893
21.144
10.230
ATOM
596
CG
LEU
A
12
−12.660
22.422
11.054
ATOM
597
CD1
LEU
A
12
−13.475
22.350
12.337
ATOM
598
CD2
LEU
A
12
−11.181
22.586
11.399
ATOM
599
N
SER
A
13
−12.971
19.476
7.771
ATOM
600
CA
SER
A
13
−12.964
18.218
7.046
ATOM
601
C
SER
A
13
−11.568
17.628
7.164
ATOM
602
O
SER
A
13
−10.613
18.320
7.550
ATOM
603
CB
SER
A
13
−13.346
18.435
5.578
ATOM
604
OG
SER
A
13
−12.404
19.261
4.923
ATOM
605
N
ALA
A
13
−11.449
16.352
6.818
ATOM
606
CA
ALA
A
13
−10.179
15.665
6.949
ATOM
607
C
ALA
A
13
−9.421
15.471
5.652
ATOM
608
O
ALA
A
13
−9.941
15.720
4.563
ATOM
609
CB
ALA
A
13
−10.413
14.306
7.626
ATOM
610
N
ILE
A
14
−8.171
15.046
5.783
ATOM
611
CA
ILE
A
14
−7.343
14.746
4.623
ATOM
612
C
ILE
A
14
−6.475
13.559
5.004
ATOM
613
O
ILE
A
14
−6.212
13.316
6.183
ATOM
614
CB
ILE
A
14
−6.401
15.916
4.183
ATOM
615
CG1
ILE
A
14
−5.284
16.106
5.200
ATOM
616
CG2
ILE
A
14
−7.188
17.211
3.982
ATOM
617
CD1
ILE
A
14
−4.173
16.973
4.696
ATOM
618
N
SER
A
15
−6.045
12.806
3.999
ATOM
619
CA
SER
A
15
−5.187
11.662
4.242
ATOM
620
C
SER
A
15
−3.740
12.089
4.217
ATOM
621
O
SER
A
15
−3.360
13.020
3.508
ATOM
622
CB
SER
A
15
−5.416
10.584
3.185
ATOM
623
OG
SER
A
15
−6.667
9.971
3.401
ATOM
624
N
MET
A
16
−2.933
11.409
5.012
ATOM
625
CA
MET
A
16
−1.518
11.700
5.047
ATOM
626
C
MET
A
16
−0.778
10.414
5.244
ATOM
627
O
MET
A
16
−1.137
9.594
6.078
ATOM
628
CB
MET
A
16
−1.170
12.694
6.164
ATOM
629
CG
MET
A
16
−1.848
14.042
5.974
ATOM
630
SD
MET
A
16
−1.017
15.431
6.760
ATOM
631
CE
MET
A
16
−0.799
14.823
8.475
ATOM
632
N
LEU
A
17
0.238
10.231
4.426
ATOM
633
CA
LEU
A
17
1.077
9.065
4.508
ATOM
634
C
LEU
A
17
2.289
9.610
5.264
ATOM
635
O
LEU
A
17
2.939
10.565
4.818
ATOM
636
CB
LEU
A
17
1.461
8.608
3.100
ATOM
637
CG
LEU
A
17
2.324
7.355
2.955
ATOM
638
CD1
LEU
A
17
1.553
6.145
3.445
ATOM
639
CD2
LEU
A
17
2.723
7.190
1.492
ATOM
640
N
TYR
A
18
2.581
9.029
6.418
ATOM
641
CA
TYR
A
18
3.706
9.501
7.196
ATOM
642
C
TYR
A
18
4.434
8.333
7.835
ATOM
643
O
TYR
A
18
4.081
7.186
7.603
ATOM
644
CB
TYR
A
18
3.222
10.458
8.281
ATOM
645
CG
TYR
A
18
2.386
9.782
9.346
ATOM
646
CD1
TYR
A
18
1.029
9.527
9.147
ATOM
647
CD2
TYR
A
18
2.961
9.379
10.550
ATOM
648
CE1
TYR
A
18
0.273
8.894
10.128
ATOM
649
CE2
TYR
A
18
2.218
8.745
11.526
ATOM
650
CZ
TYR
A
18
0.877
8.508
11.317
ATOM
651
OH
TYR
A
18
0.134
7.922
12.318
ATOM
652
N
LEU
A
19
5.439
8.651
8.650
ATOM
653
CA
LEU
A
19
6.255
7.661
9.347
ATOM
654
C
LEU
A
19
6.210
7.946
10.847
ATOM
655
O
LEU
A
19
6.685
8.992
11.288
ATOM
656
CB
LEU
A
19
7.701
7.763
8.871
ATOM
657
CG
LEU
A
19
7.901
7.850
7.359
ATOM
658
CD1
LEU
A
19
9.300
8.379
7.039
ATOM
659
CD2
LEU
A
19
7.669
6.482
6.748
116 . A method of inducing cell differentiation, tissue regeneration, or tissue formation comprising:
administering an effective amount of a functionalized biomaterial to a mesenchymal stem cell or progenitor cell at any stage of differentiation thereof, wherein said method is selected from the group consisting of a pharmaceutical method, a surgical method, a dermatological method, a prophylactic method, an imaging method and any combination thereof, wherein the administration is in vitro, ex vivo or in vivo, and wherein the functionalized biomaterial comprises at least one peptide and at least one biomaterial-affinity-containing group, wherein said at least one biomaterial-affinity-containing group provides said peptide with the ability to covalently or non-covalently interact with a biomaterial, and a biomaterial, and wherein said at least one peptide is up to 30 amino acids in length and comprises a peptide with four amino acids, PEP1; wherein PEP1 is selected from the group consisting of SAIS, NAIS and SPIS; wherein the RMSD value of the structure coordinates of said peptide or peptidomimetic with respect to PEPREF is 2.45 Å (Angstroms) or less;
and wherein PEPREF is
ATOM
511
N
LYS
A
1
−14.570
46.437
27.424
ATOM
512
CA
LYS
A
1
−13.512
45.748
28.151
ATOM
513
C
LYS
A
1
−13.655
44.259
27.884
ATOM
514
O
LYS
A
1
−12.769
43.463
28.197
ATOM
515
CB
LYS
A
1
−13.605
46.029
29.652
ATOM
516
CG
LYS
A
1
−13.640
47.509
29.991
ATOM
517
CD
LYS
A
1
−12.615
48.297
29.183
ATOM
518
CE
LYS
A
1
−12.625
49.768
29.575
ATOM
519
NZ
LYS
A
1
−13.994
50.369
29.497
ATOM
520
N
ILE
A
2
−14.792
43.890
27.309
ATOM
521
CA
ILE
A
2
−15.051
42.499
26.967
ATOM
522
C
ILE
A
2
−14.911
42.370
25.444
ATOM
523
O
ILE
A
2
−15.531
43.125
24.683
ATOM
524
CB
ILE
A
2
−16.466
42.065
27.401
ATOM
525
CG1
ILE
A
2
−16.630
42.238
28.915
ATOM
526
CG2
ILE
A
2
−16.710
40.629
26.985
ATOM
527
CD1
ILE
A
2
−15.631
41.478
29.30
ATOM
528
N
PRO
A
3
−14.085
41.411
24.989
ATOM
529
CA
PRO
A
3
−13.789
41.109
23.588
ATOM
530
C
PRO
A
3
−14.998
40.695
22.768
ATOM
531
O
PRO
A
3
−15.969
40.164
23.305
ATOM
532
CB
PRO
A
3
−12.785
39.968
23.688
ATOM
533
CG
PRO
A
3
−12.156
40.166
25.007
ATOM
534
CD
PRO
A
3
−13.330
40.506
25.867
ATOM
535
N
LYS
A
4
−14.937
40.937
21.463
ATOM
536
CA
LYS
A
4
−16.023
40.529
20.590
ATOM
537
C
LYS
A
4
−15.886
39.015
20.391
ATOM
538
O
LYS
A
4
−14.903
38.415
20.831
ATOM
539
CB
LYS
A
4
−15.926
41.244
19.245
ATOM
540
CG
LYS
A
4
−15.802
42.751
19.355
ATOM
541
CD
LYS
A
4
−16.292
43.433
18.083
ATOM
542
CE
LYS
A
4
−16.162
44.943
18.177
ATOM
543
NZ
LYS
A
4
−16.825
45.628
17.019
ATOM
544
N
ALA
A
5
−16.85
38.393
19.759
ATOM
545
CA
ALA
A
5
−16.811
36.955
19.507
ATOM
546
C
ALA
A
5
−15.772
36.771
18.416
ATOM
547
O
ALA
A
5
−15.727
37.534
17.455
ATOM
548
CB
ALA
A
5
−18.168
36.419
19.043
ATOM
549
N
CYS
A
6
−14.935
35.756
18.562
ATOM
550
CA
CYS
A
6
−13.887
35.518
17.584
ATOM
551
C
CYS
A
6
−14.347
34.765
16.338
ATOM
552
O
CYS
A
6
−15.327
34.018
16.368
ATOM
553
CB
CYS
A
6
−12.743
34.768
18.241
ATOM
554
SG
CYS
A
6
−11.198
34.959
17.353
ATOM
555
N
CYS
A
7
−13.623
34.973
15.243
ATOM
556
CA
CYS
A
7
−13.931
34.328
13.969
ATOM
557
C
CYS
A
7
−13.091
33.071
13.798
ATOM
558
O
CYS
A
7
−11.961
33.123
13.302
ATOM
559
CB
CYS
A
7
−13.653
35.290
12.824
ATOM
560
SG
CYS
A
7
−13.930
34.633
11.154
ATOM
561
N
VAL
A
8
−13.654
31.941
14.209
ATOM
562
CA
VAL
A
8
−12.949
30.684
14.110
ATOM
563
C
VAL
A
8
−13.653
29.733
13.157
ATOM
564
O
VAL
A
8
−14.759
30.016
12.687
ATOM
565
CB
VAL
A
8
−12.814
30.038
15.492
ATOM
566
CG1
VAL
A
8
−11.807
30.825
16.337
ATOM
567
CG2
VAL
A
8
−14.161
30.006
16.170
ATOM
568
N
PRO
A
9
−13.003
28.601
12.828
ATOM
569
CA
PRO
A
9
−13.593
27.615
11.918
ATOM
570
C
PRO
A
9
−14.726
26.886
12.631
ATOM
571
O
PRO
A
9
−14.581
26.476
13.780
ATOM
572
CB
PRO
A
9
−12.423
26.676
11.601
ATOM
573
CG
PRO
A
9
−11.204
27.487
11.925
ATOM
574
CD
PRO
A
9
−11.620
28.226
13.163
ATOM
575
N
THR
A
10
−15.847
26.721
11.942
ATOM
576
CA
THR
A
10
−16.999
26.060
12.527
ATOM
577
C
THR
A
10
−17.334
24.767
11.804
ATOM
578
O
THR
A
10
−18.097
23.943
12.303
ATOM
579
CB
THR
A
10
−18.211
27.010
12.523
ATOM
580
OG1
THR
A
10
−18.491
27.445
11.185
ATOM
581
CG2
THR
A
10
−17.902
28.230
13.375
ATOM
582
N
GLU
A
11
−16.750
24.586
10.627
ATOM
583
CA
GLU
A
11
−16.980
23.377
9.848
ATOM
584
C
GLU
A
11
−15.643
22.935
9.246
ATOM
585
O
GLU
A
11
−15.029
23.666
8.464
ATOM
586
CB
GLU
A
11
−17.981
23.624
8.715
ATOM
587
CG
GLU
A
11
−19.421
23.807
9.163
ATOM
588
CD
GLU
A
11
−19.686
25.166
9.770
ATOM
589
OE1
GLU
A
11
−19.478
26.175
9.073
ATOM
590
OE2
GLU
A
11
−20.111
25.227
10.939
ATOM
591
N
LEU
A
12
−15.183
21.749
9.622
ATOM
592
CA
LEU
A
12
−13.923
21.254
9.104
ATOM
593
C
LEU
A
12
−14.062
19.912
8.386
ATOM
594
O
LEU
A
12
−15.136
19.299
8.359
ATOM
595
CB
LEU
A
12
−12.893
21.144
10.230
ATOM
596
CG
LEU
A
12
−12.660
22.422
11.054
ATOM
597
CD1
LEU
A
12
−13.475
22.350
12.337
ATOM
598
CD2
LEU
A
12
−11.181
22.586
11.399
ATOM
599
N
SER
A
13
−12.971
19.476
7.771
ATOM
600
CA
SER
A
13
−12.964
18.218
7.046
ATOM
601
C
SER
A
13
−11.568
17.628
7.164
ATOM
602
O
SER
A
13
−10.613
18.320
7.550
ATOM
603
CB
SER
A
13
−13.346
18.435
5.578
ATOM
604
OG
SER
A
13
−12.404
19.261
4.923
ATOM
605
N
ALA
A
13
−11.449
16.352
6.818
ATOM
606
CA
ALA
A
13
−10.179
15.665
6.949
ATOM
607
C
ALA
A
13
−9.421
15.471
5.652
ATOM
608
O
ALA
A
13
−9.941
15.720
4.563
ATOM
609
CB
ALA
A
13
−10.413
14.306
7.626
ATOM
610
N
ILE
A
14
−8.171
15.046
5.783
ATOM
611
CA
ILE
A
14
−7.343
14.746
4.623
ATOM
612
C
ILE
A
14
−6.475
13.559
5.004
ATOM
613
O
ILE
A
14
−6.212
13.316
6.183
ATOM
614
CB
ILE
A
14
−6.401
15.916
4.183
ATOM
615
CG1
ILE
A
14
−5.284
16.106
5.200
ATOM
616
CG2
ILE
A
14
−7.188
17.211
3.982
ATOM
617
CD1
ILE
A
14
−4.173
16.973
4.696
ATOM
618
N
SER
A
15
−6.045
12.806
3.999
ATOM
619
CA
SER
A
15
−5.187
11.662
4.242
ATOM
620
C
SER
A
15
−3.740
12.089
4.217
ATOM
621
O
SER
A
15
−3.360
13.020
3.508
ATOM
622
CB
SER
A
15
−5.416
10.584
3.185
ATOM
623
OG
SER
A
15
−6.667
9.971
3.401
ATOM
624
N
MET
A
16
−2.933
11.409
5.012
ATOM
625
CA
MET
A
16
−1.518
11.700
5.047
ATOM
626
C
MET
A
16
−0.778
10.414
5.244
ATOM
627
O
MET
A
16
−1.137
9.594
6.078
ATOM
628
CB
MET
A
16
−1.170
12.694
6.164
ATOM
629
CG
MET
A
16
−1.848
14.042
5.974
ATOM
630
SD
MET
A
16
−1.017
15.431
6.760
ATOM
631
CE
MET
A
16
−0.799
14.823
8.475
ATOM
632
N
LEU
A
17
0.238
10.231
4.426
ATOM
633
CA
LEU
A
17
1.077
9.065
4.508
ATOM
634
C
LEU
A
17
2.289
9.610
5.264
ATOM
635
O
LEU
A
17
2.939
10.565
4.818
ATOM
636
CB
LEU
A
17
1.461
8.608
3.100
ATOM
637
CG
LEU
A
17
2.324
7.355
2.955
ATOM
638
CD1
LEU
A
17
1.553
6.145
3.445
ATOM
639
CD2
LEU
A
17
2.723
7.190
1.492
ATOM
640
N
TYR
A
18
2.581
9.029
6.418
ATOM
641
CA
TYR
A
18
3.706
9.501
7.196
ATOM
642
C
TYR
A
18
4.434
8.333
7.835
ATOM
643
O
TYR
A
18
4.081
7.186
7.603
ATOM
644
CB
TYR
A
18
3.222
10.458
8.281
ATOM
645
CG
TYR
A
18
2.386
9.782
9.346
ATOM
646
CD1
TYR
A
18
1.029
9.527
9.147
ATOM
647
CD2
TYR
A
18
2.961
9.379
10.550
ATOM
648
CE1
TYR
A
18
0.273
8.894
10.128
ATOM
649
CE2
TYR
A
18
2.218
8.745
11.526
ATOM
650
CZ
TYR
A
18
0.877
8.508
11.317
ATOM
651
OH
TYR
A
18
0.134
7.922
12.318
ATOM
652
N
LEU
A
19
5.439
8.651
8.650
ATOM
653
CA
LEU
A
19
6.255
7.661
9.347
ATOM
654
C
LEU
A
19
6.210
7.946
10.847
ATOM
655
O
LEU
A
19
6.685
8.992
11.288
ATOM
656
CB
LEU
A
19
7.701
7.763
8.871
ATOM
657
CG
LEU
A
19
7.901
7.850
7.359
ATOM
658
CD1
LEU
A
19
9.300
8.379
7.039
ATOM
659
CD2
LEU
A
19
7.669
6.482
6.748
117 . The method according to claim 116 , wherein said method further comprises preventing, or treating a disease, condition, disorder, or pathology, or enhancing, promoting or inducing a medical application in a patient, wherein said disease, condition, disorder, pathology or medical application is selected from the group consisting of:
enhancing osteogenesis, inducing bone formation, inducing osteocyte maturation, or treating, or preventing osteoporosis, enhancing chondrogenesis, inducing cartilage formation, inducing chondrocyte maturation, treating or preventing osteoarthritis, treating or preventing costochondritis, treating or preventing herniation, treating or preventing achondroplasia, treating, or preventing relapsing polychondritis; enhancing axonal dendritic neuron growth, promoting neuron-regeneration, treating, or preventing neuron degeneration-related conditions and diseases; enhancing fibrous tissue formation, promoting tendon and ligament regeneration, preventing, or treating tendon/ligament cell degeneration; promoting female fertility, or treating or preventing, female infertility; treating asthma, Chronic obstructive pulmonary disease, Chronic bronchitis, Emphysema, Cystic fibrosis, Pulmonary edema, Acute respiratory distress syndrome, Pneumoconiosis, Interstitial lung disease, Sarcoidosis, Idiopathic pulmonary fibrosis, Pulmonary embolism, Pulmonary hypertension, Pleural effusion, Pneumothorax, Mesothelioma, Granulomatosis with polyangiitis, Goodpasture syndrome, Pulmonary hyperplasia, Infant respiratory distress syndrome, Chronic obstructive pulmonary disease, Silicosis, Sleep Apnea, Severe Acute Respiratory Syndrome, Pulmonary fibrosis, Primary ciliary dyskinesia, Pneumoconiosis, Hypersensitivity Pneumonitis, Cryptogenic Organizing Pneumonia (Bronchiolitis Obliterans Organizing Pneumonia, Byssinosis, Bronchopulmonary Dysplasia, Bronchiolitis, Bronchiectasis, Asbestosis, Pertussis, Middle Eastern Respiratory Syndrome, Pneumonia, Tuberculosis, Bronchitis, Histoplasmosis, Coccidioidomycosis, and Acute bronchitis; treating obesity, Dercum's disease, Multiple symmetric lipomatosis, Familial multiple lipomatosis, Lipodystrophy, Lipedema, and Atherosclerosis.
118 . A surgical method for surgical treatment comprising:
contacting a body part of a patient to be treated with a peptide, wherein said contacting induces stem cell differentiation and tissue formation, and wherein the peptide is up to 30 amino acids in length and comprises a peptide with four amino acids, PEP1; wherein PEP1 is selected from the group consisting of SAIS, NAIS and SPIS;
wherein the RMSD value of the structure coordinates of said peptide or peptidomimetic with respect to PEPREF is 2.45 Å (Angstroms) or less;
and wherein PEPREF is
ATOM
511
N
LYS
A
1
−14.570
46.437
27.424
ATOM
512
CA
LYS
A
1
−13.512
45.748
28.151
ATOM
513
C
LYS
A
1
−13.655
44.259
27.884
ATOM
514
O
LYS
A
1
−12.769
43.463
28.197
ATOM
515
CB
LYS
A
1
−13.605
46.029
29.652
ATOM
516
CG
LYS
A
1
−13.640
47.509
29.991
ATOM
517
CD
LYS
A
1
−12.615
48.297
29.183
ATOM
518
CE
LYS
A
1
−12.625
49.768
29.575
ATOM
519
NZ
LYS
A
1
−13.994
50.369
29.497
ATOM
520
N
ILE
A
2
−14.792
43.890
27.309
ATOM
521
CA
ILE
A
2
−15.051
42.499
26.967
ATOM
522
C
ILE
A
2
−14.911
42.370
25.444
ATOM
523
O
ILE
A
2
−15.531
43.125
24.683
ATOM
524
CB
ILE
A
2
−16.466
42.065
27.401
ATOM
525
CG1
ILE
A
2
−16.630
42.238
28.915
ATOM
526
CG2
ILE
A
2
−16.710
40.629
26.985
ATOM
527
CD1
ILE
A
2
−15.631
41.478
29.30
ATOM
528
N
PRO
A
3
−14.085
41.411
24.989
ATOM
529
CA
PRO
A
3
−13.789
41.109
23.588
ATOM
530
C
PRO
A
3
−14.998
40.695
22.768
ATOM
531
O
PRO
A
3
−15.969
40.164
23.305
ATOM
532
CB
PRO
A
3
−12.785
39.968
23.688
ATOM
533
CG
PRO
A
3
−12.156
40.166
25.007
ATOM
534
CD
PRO
A
3
−13.330
40.506
25.867
ATOM
535
N
LYS
A
4
−14.937
40.937
21.463
ATOM
536
CA
LYS
A
4
−16.023
40.529
20.590
ATOM
537
C
LYS
A
4
−15.886
39.015
20.391
ATOM
538
O
LYS
A
4
−14.903
38.415
20.831
ATOM
539
CB
LYS
A
4
−15.926
41.244
19.245
ATOM
540
CG
LYS
A
4
−15.802
42.751
19.355
ATOM
541
CD
LYS
A
4
−16.292
43.433
18.083
ATOM
542
CE
LYS
A
4
−16.162
44.943
18.177
ATOM
543
NZ
LYS
A
4
−16.825
45.628
17.019
ATOM
544
N
ALA
A
5
−16.85
38.393
19.759
ATOM
545
CA
ALA
A
5
−16.811
36.955
19.507
ATOM
546
C
ALA
A
5
−15.772
36.771
18.416
ATOM
547
O
ALA
A
5
−15.727
37.534
17.455
ATOM
548
CB
ALA
A
5
−18.168
36.419
19.043
ATOM
549
N
CYS
A
6
−14.935
35.756
18.562
ATOM
550
CA
CYS
A
6
−13.887
35.518
17.584
ATOM
551
C
CYS
A
6
−14.347
34.765
16.338
ATOM
552
O
CYS
A
6
−15.327
34.018
16.368
ATOM
553
CB
CYS
A
6
−12.743
34.768
18.241
ATOM
554
SG
CYS
A
6
−11.198
34.959
17.353
ATOM
555
N
CYS
A
7
−13.623
34.973
15.243
ATOM
556
CA
CYS
A
7
−13.931
34.328
13.969
ATOM
557
C
CYS
A
7
−13.091
33.071
13.798
ATOM
558
O
CYS
A
7
−11.961
33.123
13.302
ATOM
559
CB
CYS
A
7
−13.653
35.290
12.824
ATOM
560
SG
CYS
A
7
−13.930
34.633
11.154
ATOM
561
N
VAL
A
8
−13.654
31.941
14.209
ATOM
562
CA
VAL
A
8
−12.949
30.684
14.110
ATOM
563
C
VAL
A
8
−13.653
29.733
13.157
ATOM
564
O
VAL
A
8
−14.759
30.016
12.687
ATOM
565
CB
VAL
A
8
−12.814
30.038
15.492
ATOM
566
CG1
VAL
A
8
−11.807
30.825
16.337
ATOM
567
CG2
VAL
A
8
−14.161
30.006
16.170
ATOM
568
N
PRO
A
9
−13.003
28.601
12.828
ATOM
569
CA
PRO
A
9
−13.593
27.615
11.918
ATOM
570
C
PRO
A
9
−14.726
26.886
12.631
ATOM
571
O
PRO
A
9
−14.581
26.476
13.780
ATOM
572
CB
PRO
A
9
−12.423
26.676
11.601
ATOM
573
CG
PRO
A
9
−11.204
27.487
11.925
ATOM
574
CD
PRO
A
9
−11.620
28.226
13.163
ATOM
575
N
THR
A
10
−15.847
26.721
11.942
ATOM
576
CA
THR
A
10
−16.999
26.060
12.527
ATOM
577
C
THR
A
10
−17.334
24.767
11.804
ATOM
578
O
THR
A
10
−18.097
23.943
12.303
ATOM
579
CB
THR
A
10
−18.211
27.010
12.523
ATOM
580
OG1
THR
A
10
−18.491
27.445
11.185
ATOM
581
CG2
THR
A
10
−17.902
28.230
13.375
ATOM
582
N
GLU
A
11
−16.750
24.586
10.627
ATOM
583
CA
GLU
A
11
−16.980
23.377
9.848
ATOM
584
C
GLU
A
11
−15.643
22.935
9.246
ATOM
585
O
GLU
A
11
−15.029
23.666
8.464
ATOM
586
CB
GLU
A
11
−17.981
23.624
8.715
ATOM
587
CG
GLU
A
11
−19.421
23.807
9.163
ATOM
588
CD
GLU
A
11
−19.686
25.166
9.770
ATOM
589
OE1
GLU
A
11
−19.478
26.175
9.073
ATOM
590
OE2
GLU
A
11
−20.111
25.227
10.939
ATOM
591
N
LEU
A
12
−15.183
21.749
9.622
ATOM
592
CA
LEU
A
12
−13.923
21.254
9.104
ATOM
593
C
LEU
A
12
−14.062
19.912
8.386
ATOM
594
O
LEU
A
12
−15.136
19.299
8.359
ATOM
595
CB
LEU
A
12
−12.893
21.144
10.230
ATOM
596
CG
LEU
A
12
−12.660
22.422
11.054
ATOM
597
CD1
LEU
A
12
−13.475
22.350
12.337
ATOM
598
CD2
LEU
A
12
−11.181
22.586
11.399
ATOM
599
N
SER
A
13
−12.971
19.476
7.771
ATOM
600
CA
SER
A
13
−12.964
18.218
7.046
ATOM
601
C
SER
A
13
−11.568
17.628
7.164
ATOM
602
O
SER
A
13
−10.613
18.320
7.550
ATOM
603
CB
SER
A
13
−13.346
18.435
5.578
ATOM
604
OG
SER
A
13
−12.404
19.261
4.923
ATOM
605
N
ALA
A
13
−11.449
16.352
6.818
ATOM
606
CA
ALA
A
13
−10.179
15.665
6.949
ATOM
607
C
ALA
A
13
−9.421
15.471
5.652
ATOM
608
O
ALA
A
13
−9.941
15.720
4.563
ATOM
609
CB
ALA
A
13
−10.413
14.306
7.626
ATOM
610
N
ILE
A
14
−8.171
15.046
5.783
ATOM
611
CA
ILE
A
14
−7.343
14.746
4.623
ATOM
612
C
ILE
A
14
−6.475
13.559
5.004
ATOM
613
O
ILE
A
14
−6.212
13.316
6.183
ATOM
614
CB
ILE
A
14
−6.401
15.916
4.183
ATOM
615
CG1
ILE
A
14
−5.284
16.106
5.200
ATOM
616
CG2
ILE
A
14
−7.188
17.211
3.982
ATOM
617
CD1
ILE
A
14
−4.173
16.973
4.696
ATOM
618
N
SER
A
15
−6.045
12.806
3.999
ATOM
619
CA
SER
A
15
−5.187
11.662
4.242
ATOM
620
C
SER
A
15
−3.740
12.089
4.217
ATOM
621
O
SER
A
15
−3.360
13.020
3.508
ATOM
622
CB
SER
A
15
−5.416
10.584
3.185
ATOM
623
OG
SER
A
15
−6.667
9.971
3.401
ATOM
624
N
MET
A
16
−2.933
11.409
5.012
ATOM
625
CA
MET
A
16
−1.518
11.700
5.047
ATOM
626
C
MET
A
16
−0.778
10.414
5.244
ATOM
627
O
MET
A
16
−1.137
9.594
6.078
ATOM
628
CB
MET
A
16
−1.170
12.694
6.164
ATOM
629
CG
MET
A
16
−1.848
14.042
5.974
ATOM
630
SD
MET
A
16
−1.017
15.431
6.760
ATOM
631
CE
MET
A
16
−0.799
14.823
8.475
ATOM
632
N
LEU
A
17
0.238
10.231
4.426
ATOM
633
CA
LEU
A
17
1.077
9.065
4.508
ATOM
634
C
LEU
A
17
2.289
9.610
5.264
ATOM
635
O
LEU
A
17
2.939
10.565
4.818
ATOM
636
CB
LEU
A
17
1.461
8.608
3.100
ATOM
637
CG
LEU
A
17
2.324
7.355
2.955
ATOM
638
CD1
LEU
A
17
1.553
6.145
3.445
ATOM
639
CD2
LEU
A
17
2.723
7.190
1.492
ATOM
640
N
TYR
A
18
2.581
9.029
6.418
ATOM
641
CA
TYR
A
18
3.706
9.501
7.196
ATOM
642
C
TYR
A
18
4.434
8.333
7.835
ATOM
643
O
TYR
A
18
4.081
7.186
7.603
ATOM
644
CB
TYR
A
18
3.222
10.458
8.281
ATOM
645
CG
TYR
A
18
2.386
9.782
9.346
ATOM
646
CD1
TYR
A
18
1.029
9.527
9.147
ATOM
647
CD2
TYR
A
18
2.961
9.379
10.550
ATOM
648
CE1
TYR
A
18
0.273
8.894
10.128
ATOM
649
CE2
TYR
A
18
2.218
8.745
11.526
ATOM
650
CZ
TYR
A
18
0.877
8.508
11.317
ATOM
651
OH
TYR
A
18
0.134
7.922
12.318
ATOM
652
N
LEU
A
19
5.439
8.651
8.650
ATOM
653
CA
LEU
A
19
6.255
7.661
9.347
ATOM
654
C
LEU
A
19
6.210
7.946
10.847
ATOM
655
O
LEU
A
19
6.685
8.992
11.288
ATOM
656
CB
LEU
A
19
7.701
7.763
8.871
ATOM
657
CG
LEU
A
19
7.901
7.850
7.359
ATOM
658
CD1
LEU
A
19
9.300
8.379
7.039
ATOM
659
CD2
LEU
A
19
7.669
6.482
6.748
119 . A surgical method for surgical treatment comprising:
contacting a body part of a patient to be treated with a functionalized biomaterial, wherein said contacting induces stem cell differentiation and tissue formation, and wherein the functionalized biomaterial comprises at least one peptide and at least one biomaterial-affinity-containing group, wherein said at least one biomaterial-affinity-containing group provides said peptide with the ability to covalently or non-covalently interact with a biomaterial, and a biomaterial, and wherein said at least one peptide is up to 30 amino acids in length and comprises a peptide with four amino acids, PEP1; wherein PEP1 is selected from the group consisting of SAIS, NAIS, and SPIS; wherein the RMSD value of the structure coordinates of said peptide or peptidomimetic with respect to PEPREF is 2.45 Å (Angstroms) or less;
and wherein PEPREF is
ATOM
511
N
LYS
A
1
−14.570
46.437
27.424
ATOM
512
CA
LYS
A
1
−13.512
45.748
28.151
ATOM
513
C
LYS
A
1
−13.655
44.259
27.884
ATOM
514
O
LYS
A
1
−12.769
43.463
28.197
ATOM
515
CB
LYS
A
1
−13.605
46.029
29.652
ATOM
516
CG
LYS
A
1
−13.640
47.509
29.991
ATOM
517
CD
LYS
A
1
−12.615
48.297
29.183
ATOM
518
CE
LYS
A
1
−12.625
49.768
29.575
ATOM
519
NZ
LYS
A
1
−13.994
50.369
29.497
ATOM
520
N
ILE
A
2
−14.792
43.890
27.309
ATOM
521
CA
ILE
A
2
−15.051
42.499
26.967
ATOM
522
C
ILE
A
2
−14.911
42.370
25.444
ATOM
523
O
ILE
A
2
−15.531
43.125
24.683
ATOM
524
CB
ILE
A
2
−16.466
42.065
27.401
ATOM
525
CG1
ILE
A
2
−16.630
42.238
28.915
ATOM
526
CG2
ILE
A
2
−16.710
40.629
26.985
ATOM
527
CD1
ILE
A
2
−15.631
41.478
29.30
ATOM
528
N
PRO
A
3
−14.085
41.411
24.989
ATOM
529
CA
PRO
A
3
−13.789
41.109
23.588
ATOM
530
C
PRO
A
3
−14.998
40.695
22.768
ATOM
531
O
PRO
A
3
−15.969
40.164
23.305
ATOM
532
CB
PRO
A
3
−12.785
39.968
23.688
ATOM
533
CG
PRO
A
3
−12.156
40.166
25.007
ATOM
534
CD
PRO
A
3
−13.330
40.506
25.867
ATOM
535
N
LYS
A
4
−14.937
40.937
21.463
ATOM
536
CA
LYS
A
4
−16.023
40.529
20.590
ATOM
537
C
LYS
A
4
−15.886
39.015
20.391
ATOM
538
O
LYS
A
4
−14.903
38.415
20.831
ATOM
539
CB
LYS
A
4
−15.926
41.244
19.245
ATOM
540
CG
LYS
A
4
−15.802
42.751
19.355
ATOM
541
CD
LYS
A
4
−16.292
43.433
18.083
ATOM
542
CE
LYS
A
4
−16.162
44.943
18.177
ATOM
543
NZ
LYS
A
4
−16.825
45.628
17.019
ATOM
544
N
ALA
A
5
−16.85
38.393
19.759
ATOM
545
CA
ALA
A
5
−16.811
36.955
19.507
ATOM
546
C
ALA
A
5
−15.772
36.771
18.416
ATOM
547
O
ALA
A
5
−15.727
37.534
17.455
ATOM
548
CB
ALA
A
5
−18.168
36.419
19.043
ATOM
549
N
CYS
A
6
−14.935
35.756
18.562
ATOM
550
CA
CYS
A
6
−13.887
35.518
17.584
ATOM
551
C
CYS
A
6
−14.347
34.765
16.338
ATOM
552
O
CYS
A
6
−15.327
34.018
16.368
ATOM
553
CB
CYS
A
6
−12.743
34.768
18.241
ATOM
554
SG
CYS
A
6
−11.198
34.959
17.353
ATOM
555
N
CYS
A
7
−13.623
34.973
15.243
ATOM
556
CA
CYS
A
7
−13.931
34.328
13.969
ATOM
557
C
CYS
A
7
−13.091
33.071
13.798
ATOM
558
O
CYS
A
7
−11.961
33.123
13.302
ATOM
559
CB
CYS
A
7
−13.653
35.290
12.824
ATOM
560
SG
CYS
A
7
−13.930
34.633
11.154
ATOM
561
N
VAL
A
8
−13.654
31.941
14.209
ATOM
562
CA
VAL
A
8
−12.949
30.684
14.110
ATOM
563
C
VAL
A
8
−13.653
29.733
13.157
ATOM
564
O
VAL
A
8
−14.759
30.016
12.687
ATOM
565
CB
VAL
A
8
−12.814
30.038
15.492
ATOM
566
CG1
VAL
A
8
−11.807
30.825
16.337
ATOM
567
CG2
VAL
A
8
−14.161
30.006
16.170
ATOM
568
N
PRO
A
9
−13.003
28.601
12.828
ATOM
569
CA
PRO
A
9
−13.593
27.615
11.918
ATOM
570
C
PRO
A
9
−14.726
26.886
12.631
ATOM
571
O
PRO
A
9
−14.581
26.476
13.780
ATOM
572
CB
PRO
A
9
−12.423
26.676
11.601
ATOM
573
CG
PRO
A
9
−11.204
27.487
11.925
ATOM
574
CD
PRO
A
9
−11.620
28.226
13.163
ATOM
575
N
THR
A
10
−15.847
26.721
11.942
ATOM
576
CA
THR
A
10
−16.999
26.060
12.527
ATOM
577
C
THR
A
10
−17.334
24.767
11.804
ATOM
578
O
THR
A
10
−18.097
23.943
12.303
ATOM
579
CB
THR
A
10
−18.211
27.010
12.523
ATOM
580
OG1
THR
A
10
−18.491
27.445
11.185
ATOM
581
CG2
THR
A
10
−17.902
28.230
13.375
ATOM
582
N
GLU
A
11
−16.750
24.586
10.627
ATOM
583
CA
GLU
A
11
−16.980
23.377
9.848
ATOM
584
C
GLU
A
11
−15.643
22.935
9.246
ATOM
585
O
GLU
A
11
−15.029
23.666
8.464
ATOM
586
CB
GLU
A
11
−17.981
23.624
8.715
ATOM
587
CG
GLU
A
11
−19.421
23.807
9.163
ATOM
588
CD
GLU
A
11
−19.686
25.166
9.770
ATOM
589
OE1
GLU
A
11
−19.478
26.175
9.073
ATOM
590
OE2
GLU
A
11
−20.111
25.227
10.939
ATOM
591
N
LEU
A
12
−15.183
21.749
9.622
ATOM
592
CA
LEU
A
12
−13.923
21.254
9.104
ATOM
593
C
LEU
A
12
−14.062
19.912
8.386
ATOM
594
O
LEU
A
12
−15.136
19.299
8.359
ATOM
595
CB
LEU
A
12
−12.893
21.144
10.230
ATOM
596
CG
LEU
A
12
−12.660
22.422
11.054
ATOM
597
CD1
LEU
A
12
−13.475
22.350
12.337
ATOM
598
CD2
LEU
A
12
−11.181
22.586
11.399
ATOM
599
N
SER
A
13
−12.971
19.476
7.771
ATOM
600
CA
SER
A
13
−12.964
18.218
7.046
ATOM
601
C
SER
A
13
−11.568
17.628
7.164
ATOM
602
O
SER
A
13
−10.613
18.320
7.550
ATOM
603
CB
SER
A
13
−13.346
18.435
5.578
ATOM
604
OG
SER
A
13
−12.404
19.261
4.923
ATOM
605
N
ALA
A
13
−11.449
16.352
6.818
ATOM
606
CA
ALA
A
13
−10.179
15.665
6.949
ATOM
607
C
ALA
A
13
−9.421
15.471
5.652
ATOM
608
O
ALA
A
13
−9.941
15.720
4.563
ATOM
609
CB
ALA
A
13
−10.413
14.306
7.626
ATOM
610
N
ILE
A
14
−8.171
15.046
5.783
ATOM
611
CA
ILE
A
14
−7.343
14.746
4.623
ATOM
612
C
ILE
A
14
−6.475
13.559
5.004
ATOM
613
O
ILE
A
14
−6.212
13.316
6.183
ATOM
614
CB
ILE
A
14
−6.401
15.916
4.183
ATOM
615
CG1
ILE
A
14
−5.284
16.106
5.200
ATOM
616
CG2
ILE
A
14
−7.188
17.211
3.982
ATOM
617
CD1
ILE
A
14
−4.173
16.973
4.696
ATOM
618
N
SER
A
15
−6.045
12.806
3.999
ATOM
619
CA
SER
A
15
−5.187
11.662
4.242
ATOM
620
C
SER
A
15
−3.740
12.089
4.217
ATOM
621
O
SER
A
15
−3.360
13.020
3.508
ATOM
622
CB
SER
A
15
−5.416
10.584
3.185
ATOM
623
OG
SER
A
15
−6.667
9.971
3.401
ATOM
624
N
MET
A
16
−2.933
11.409
5.012
ATOM
625
CA
MET
A
16
−1.518
11.700
5.047
ATOM
626
C
MET
A
16
−0.778
10.414
5.244
ATOM
627
O
MET
A
16
−1.137
9.594
6.078
ATOM
628
CB
MET
A
16
−1.170
12.694
6.164
ATOM
629
CG
MET
A
16
−1.848
14.042
5.974
ATOM
630
SD
MET
A
16
−1.017
15.431
6.760
ATOM
631
CE
MET
A
16
−0.799
14.823
8.475
ATOM
632
N
LEU
A
17
0.238
10.231
4.426
ATOM
633
CA
LEU
A
17
1.077
9.065
4.508
ATOM
634
C
LEU
A
17
2.289
9.610
5.264
ATOM
635
O
LEU
A
17
2.939
10.565
4.818
ATOM
636
CB
LEU
A
17
1.461
8.608
3.100
ATOM
637
CG
LEU
A
17
2.324
7.355
2.955
ATOM
638
CD1
LEU
A
17
1.553
6.145
3.445
ATOM
639
CD2
LEU
A
17
2.723
7.190
1.492
ATOM
640
N
TYR
A
18
2.581
9.029
6.418
ATOM
641
CA
TYR
A
18
3.706
9.501
7.196
ATOM
642
C
TYR
A
18
4.434
8.333
7.835
ATOM
643
O
TYR
A
18
4.081
7.186
7.603
ATOM
644
CB
TYR
A
18
3.222
10.458
8.281
ATOM
645
CG
TYR
A
18
2.386
9.782
9.346
ATOM
646
CD1
TYR
A
18
1.029
9.527
9.147
ATOM
647
CD2
TYR
A
18
2.961
9.379
10.550
ATOM
648
CE1
TYR
A
18
0.273
8.894
10.128
ATOM
649
CE2
TYR
A
18
2.218
8.745
11.526
ATOM
650
CZ
TYR
A
18
0.877
8.508
11.317
ATOM
651
OH
TYR
A
18
0.134
7.922
12.318
ATOM
652
N
LEU
A
19
5.439
8.651
8.650
ATOM
653
CA
LEU
A
19
6.255
7.661
9.347
ATOM
654
C
LEU
A
19
6.210
7.946
10.847
ATOM
655
O
LEU
A
19
6.685
8.992
11.288
ATOM
656
CB
LEU
A
19
7.701
7.763
8.871
ATOM
657
CG
LEU
A
19
7.901
7.850
7.359
ATOM
658
CD1
LEU
A
19
9.300
8.379
7.039
ATOM
659
CD2
LEU
A
19
7.669
6.482
6.748
120 . The functionalized biomaterial according to claim 114 , wherein said solid ceramic component is selected from a granulated ceramic powder or ceramic scaffold; and/or a gel ceramic component.
121 . The functionalized biomaterial according to claim 114 , wherein the collagen is selected from collagen type I, II, III and/or XI.Join the waitlist — get patent alerts
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