Systems, devices and related methods of controlling insulin management for delivering insulin during a fasting period

Abstract

An insulin management method implemented by an insulin delivery device is provided. The method includes detecting a starting activity associated with preparation of use of the insulin delivery device in the form of an automatic insulin delivery device attachable to a user's body for a duration of a fasting period within an overall time period. The method includes initiating automated delivery of insulin in the form correction bolus doses in response to periodically received blood glucose measurements during the fasting period. Other methods, devices and systems are also provided.

1 . An insulin management method implemented by an insulin delivery device, comprising:
 detecting a starting activity associated with preparation of use of the insulin delivery device in the form of an automatic insulin delivery device attachable to a user's body for a duration of a fasting period within an overall time period; and   initiating automated delivery of insulin in the form correction bolus doses in response to periodically received blood glucose measurements during the fasting period.   
     
     
         2 . The method of  claim 1  comprising:
 detecting an ending activity associated with ending the use of the insulin delivery device; and 
 terminating automated delivery of the insulin correction bolus doses. 
 
     
     
         3 . The method of  claim 1 , wherein the starting activity has a primary function other than initiating automated delivery of insulin from the insulin delivery device, thereby, being simultaneously reused as an indication to initiate automated delivery of insulin from the insulin delivery device. 
     
     
         4 . The method of  claim 1 , wherein the starting activity comprises one or more of:
 arrival of a pre-set time of the day;   removal of the insulin delivery device from a power charger; and   attachment of a disposable insulin dispensing unit to the insulin delivery device.   
     
     
         5 . The method of  claim 1 , wherein the starting activity comprises one or more of:
 attachment of the insulin delivery device to the user;   detachment of an applicator of the insulin delivery device from the insulin delivery device; and   a verbal command or selection by the user indicating a desire to initiate automated delivery of insulin.   
     
     
         6 . The method of  claim 1 , wherein the starting activity comprises at least one of:
 a proximity to or pairing of a controller of the insulin delivery device to a user computing device on which a user application associated with the insulin delivery device is installed;   a proximity to or pairing of the controller of the insulin delivery device to a smart insulin pen;   a fill level of an insulin reservoir of a disposable insulin dispensing unit indicative of a sufficiently filled insulin reservoir for initiating the automated delivery of insulin;   a movement of a plunger of an insulin reservoir of a disposable insulin dispensing unit indicative of a filing of the insulin reservoir.   
     
     
         7 . The method of  claim 1 , comprising receiving from a paired user computing device a total daily basal dose information as received from a non-fasting insulin management modality in a defined period prior to the fasting period for use in determining the correction bolus doses. 
     
     
         8 . The method of  claim 1 , wherein initiating automated delivery of insulin includes priming the delivery device to be ready to deliver the insulin. 
     
     
         9 . The method of  claim 1 , wherein the insulin delivery device refrains from administering basal insulin at a preset or default rate or in a preset or default pattern. 
     
     
         10 . The method of  claim 1 , comprising delivering insulin in the form of the correction bolus doses in response to received blood glucose measurements, the correction bolus doses compensated by a determined insulin on board. 
     
     
         11 . The method of  claim 10 , comprising delivering at least a first correction bolus dose that is compensated for by the determined insulin on board set equal to an assumed insulin on board that is determined based on an assumed external dose calculated to correct an initial blood glucose value of the user to a target blood glucose. 
     
     
         12 . The method of  claim 10  comprising calculating correction bolus doses by comparing an evaluated blood glucose measurement to a target blood glucose to obtain a difference, the difference adjusted by a user insulin sensitivity factor to obtain a resultant dose amount, the resultant dose amount compensated by the determined insulin on board. 
     
     
         13 . The method of  claim 10 , wherein the determined insulin on board includes the assumed insulin on board and a known delivered insulin from the delivery device. 
     
     
         14 . The method of  claim 10 , wherein the correction bolus doses are based on a user's insulin sensitivity factor derived from a total daily basal dose information used in a defined period prior to the fasting period. 
     
     
         15 . The method of  claim 14 , wherein the total daily basal dose information is an average total number of basal dose units given in an overall time period. 
     
     
         16 . An insulin management system of an insulin delivery device in the form of an automatic insulin delivery device attachable to a user's body for a duration of a fasting period within an overall time period, the system comprising:
 an activation component configured to detect a starting activity associated with preparation of use of the insulin delivery device; and   a delivery component configured to initiate automated delivery of insulin in the form of correction bolus doses in response to periodically received blood glucose measurements during the fasting period.   
     
     
         17 . The system of  claim 16 , including:
 an end detecting component configured to detect an ending activity associated with ending the use of the insulin delivery device.   
     
     
         18 . The system of  claim 16 , wherein the starting activity has a primary function other than initiating automated delivery of insulin from the insulin delivery device, thereby, being simultaneously reused as an indication to initiate automated delivery of insulin from the insulin delivery device. 
     
     
         19 . The system of  claim 16 , wherein the activation component is configured to detect, as the starting activity, one or more of:
 arrival of a pre-set time of the day as the starting activity;   removal of the insulin delivery device from a power charger; and   attachment of a disposable insulin dispensing unit to the insulin delivery device.   
     
     
         20 . The system of  claim 16 , wherein the activation component is configured to detect, as the starting activity, one or more of:
 attachment of the insulin delivery device to the user;   detachment of an applicator of the insulin delivery device from the insulin delivery device; and   a verbal command or selection by the user indicating a desire to initiate automated delivery of insulin.   
     
     
         21 . The system of  claim 16 , wherein the activation component is configured to detect, as the starting activity, one or more of:
 a proximity to or pairing of a controller of the insulin delivery device to a user computing device on which a user application associated with the insulin delivery device is installed   a proximity to or pairing of the controller of the insulin delivery device to a smart insulin pen;   a fill level of an insulin reservoir of a disposable insulin dispensing unit indicative of a sufficiently filled insulin reservoir for initiating the automated delivery of insulin;   a movement of a plunger of an insulin reservoir of a disposable insulin dispensing unit indicative of a filing of the insulin reservoir.   
     
     
         22 . The system of  claim 21 , wherein the activation component detects receiving, from the paired user computing device, a total daily basal dose information as received from a non-fasting insulin management modality in a defined period prior to the fasting period for use in determining the correction bolus doses. 
     
     
         23 . The system of  claim 16 , wherein the delivery component is configured to prime the delivery device to be ready to deliver the insulin. 
     
     
         24 . The system of  claim 16 , wherein the delivery component comprises a processor and a memory configured to provide non-transitory, computer-readable program instructions to the processor to execute functions of the components. 
     
     
         25 . The system of  claim 16 , including a mobile user computing device comprising:
 a processor and a memory configured to provide non-transitory, computer-readable program instructions to the processor to execute functions of components;   a basal insulin input component configured to request a value from a user of a total daily basal dose information used in a defined period prior to the fasting period; and   a controller pairing component configured to pair the mobile user computing device to a controller of the delivery device.   
     
     
         26 . An automatic insulin delivery device attachable to a user's body for a duration of a fasting period, the device comprising:
 a durable portion including a delivery component configured to control a delivery of insulin in the form of correction bolus doses in response to received blood glucose measurements, the delivery component comprising:
 an activation component configured to detect a starting activity associated with preparation of use of the insulin delivery device; and 
 a delivery component configured to initiate automated delivery of insulin in the form of correction bolus doses in response to periodically received blood glucose measurements during the fasting period; and 
   a disposable portion comprising a reservoir configured to contain insulin and configured to automatically deliver the correction bolus doses to the user.   
     
     
         27 . The device of  claim 26 , wherein the reservoir is configured to be fillable from a non-fasting insulin injection device used during a non-fasting period preceding the fasting period. 
     
     
         28 . A computer-implemented method for managing delivery of insulin during a fasting period from a delivery device in the form of a wearable automated insulin delivery device worn for the fasting period, wherein the method is carried out by a computing application provided at a mobile user computing device, the method comprising:
 requesting from a user a value of a total daily basal dose information used in a defined period prior to the fasting period;   pairing the mobile user computing device to a controller of the delivery device, the controller detecting a starting activity associated with preparation of use of the insulin delivery device, thereby, initiating automated delivery of insulin in the form correction bolus doses in response to periodically received blood glucose measurements during the fasting period; and   transmitting and receiving information to and from the controller of the delivery device during the fasting period.   
     
     
         29 . The method of  claim 28 , wherein the value from the user of the total daily basal dose information includes a usual number of units of basal insulin received from a non-fasting form of insulin therapy. 
     
     
         30 . The method of  claim 28 , wherein the method includes pairing the mobile user computing device to a blood glucose monitor, thereby, allowing transfer of blood glucose measurements to the delivery device via the mobile user computing device. 
     
     
         31 . The method of  claim 28 , comprising providing a display of a session history of information relating to a fasting period to the user. 
     
     
         32 . The method of  claim 28 , comprising providing user training in use of a delivery device to the user. 
     
     
         33 . The method of  claim 28 , comprising coordinating a fast-ending procedure for the user including dividing a fast-ending meal bolus into a first portion equal to a remaining insulin in the delivery device at the end of the fasting period and a second portion to be delivered to the user utilizing a delivery method other than the delivery device in a non-fasting period immediately following the fasting period. 
     
     
         34 . An insulin management method of use of an insulin delivery device in the form of an automatic insulin delivery device attachable to a user's body for a duration of a fasting period within an overall time period, the method comprising:
 carrying out a starting activity associated with preparation of use of the insulin delivery device; and   receiving automated delivery of insulin in the form correction bolus doses in response to periodically received blood glucose measurements during the fasting period.   
     
     
         35 . The method of  claim 34  including:
 carrying out an ending activity associated with ending the user of the insulin delivery device. 
 
     
     
         36 . The method of  claim 34 , wherein carrying out the starting activity comprises one or more of:
 removal of the insulin delivery device from a power charger; and   attachment of a disposable insulin dispensing unit to the insulin delivery device.   
     
     
         37 . The method of  claim 34 , wherein carrying out the starting activity comprises one or more of:
 attachment of the insulin delivery device to the user;   detachment of an applicator of the insulin delivery device from the insulin delivery device; and   a verbal command or selection by the user indicating a desire to initiate automated delivery of insulin.   
     
     
         38 . The method of  claim 34 , wherein carrying out the starting activity comprises at least one of:
 pairing a controller of the insulin delivery device to a user computing device on which a user application associated with the insulin delivery device is installed   pairing the controller of the insulin delivery device to a smart insulin pen;   filling an insulin reservoir of a disposable insulin dispensing unit;   causing movement of a plunger of the insulin reservoir indicative of a filing of the insulin reservoir.   
     
     
         39 . The method of  claim 34 , comprising providing at least one of an insulin sensitivity factor and total daily basal dose information used by the user in a defined period prior to the fasting period to the insulin delivery device.