Integrated Thrombectomy and Filter Device and Methods of Use

Abstract

The invention relates generally to methods and systems for capturing, filtering, or retrieving obstructions or other particulates from a patient's vasculature. In one aspect, device for retrieving an obstruction from a patient is provided that includes an outer delivery shaft and an expandable basket movable between a collapsed configuration and an expanded configuration. The basket is configured to be in the collapsed configuration during delivery and in the expanded configuration during engagement and retrieval of the obstruction. A proximal end of the basket is configured to be centrally and pivotally coupled to the outer delivery shaft. The proximal end and/or a distal end of the basket is movable relative to each other such that a proximal portion of the expandable basket is invertible toward a distal portion of the basket to form a proximally oriented cavity in the expanded configuration to engage and retrieve the obstruction.

1 .- 69 . (canceled) 
     
     
         70 . An intravascular device for filtering particulates released during an intravascular procedure performed upon a patient to prevent distal migration of the released particulates, the intravascular device comprising:
 an outer delivery shaft; and   an expandable basket movable between a collapsed configuration and an expanded configuration, the expandable basket configured to be in the collapsed configuration during delivery into a vasculature of the patient and in the expanded configuration to filter particulates released during the intravascular procedure, the expandable basket including a proximal end and a distal end, the proximal end configured to be centrally and pivotally coupled to the outer delivery shaft, and wherein at least one of the proximal end or the distal end is movable relative to each other such that a proximal portion of the expandable basket is invertible towards a distal portion of the expandable basket to form a proximally oriented cavity configured to filter the released particulates therein.   
     
     
         71 . The intravascular device of  claim 70 , wherein the expandable basket in the expanded configuration further comprises an integral anchor configured to maintain vessel opposition and fixation of the expandable basket. 
     
     
         72 . The intravascular device of  claim 70 , wherein after withdrawal of a delivery catheter through which the intravascular device was advanced, an aspiration catheter is configured to be navigated toward the anchored expandable basket, wherein the anchored expandable basket provides a substantially fixed pre-positioned guide to the particulates of a thrombus. 
     
     
         73 . The intravascular device of  claim 70 , wherein the proximal end of the expandable basket is pivotally coupled to the outer delivery shaft at a distal portion of the outer delivery shaft. 
     
     
         74 . The intravascular device of  claim 70 , further comprising an inner core wire extending coaxially through the outer delivery shaft, a distal portion of the inner core wire coupled to the distal end of the expandable basket. 
     
     
         75 . The intravascular device of  claim 74 , further comprising a handle coupled to the outer delivery shaft and the inner core wire, the handle including one or more locking mechanisms configured to secure a position of the outer delivery shaft relative to a position of the inner core wire. 
     
     
         76 . The intravascular device of  claim 74 , further comprising a coil extending around a distal tip of the inner core wire. 
     
     
         77 . The intravascular device of  claim 74 , wherein the inner core wire comprises a cylindrical portion and a flattened portion, wherein the flattened portion is at a distal end of the inner core wire. 
     
     
         78 . The intravascular device of  claim 74 , wherein the inner core wire tapers in diameter from a proximal portion to a distal portion of the inner core wire. 
     
     
         79 . The intravascular device of  claim 74 , wherein the inner core wire is configured to be releasably coupled to an extender wire. 
     
     
         80 . The intravascular device of  claim 79 , wherein the extender wire is releasably coupled to the inner core wire via one or more extender hypotubes. 
     
     
         81 . The intravascular device of  claim 70 , wherein the proximally oriented cavity has a cup-shaped cavity. 
     
     
         82 .- 83 . (canceled) 
     
     
         84 . The intravascular device of  claim 70 , wherein the proximal end of the expandable basket is spaced radially inward from a peripheral edge of the distal portion of the expandable basket when the proximal portion is inverted towards the distal portion of the expandable basket. 
     
     
         85 . The intravascular device of  claim 70 , wherein axial positions of the proximal and distal ends of the expandable basket are securable relative to each other after the proximal portion of the expandable basket is inverted towards the distal portion of the expandable basket to form the proximally oriented cavity. 
     
     
         86 . The intravascular device of  claim 85 , wherein the proximal and distal ends of the expandable basket are securable relative to each other in a plurality of axial positions such that a shape or size of the proximally oriented cavity is adjustable. 
     
     
         87 . The intravascular device of  claim 70 , wherein the expandable basket comprises support ribs. 
     
     
         88 . The intravascular device of  claim 70 , wherein a portion of the expandable basket comprises multiple layers. 
     
     
         89 . The intravascular device of  claim 88 , wherein the multiple layers include an inner layer and an outer layer. 
     
     
         90 . The intravascular device of  claim 89 , wherein the inner layer is configured to expand to a larger diameter relative to the outer layer when the expandable basket is moved to a partially expanded configuration between the collapsed configuration and expanded configuration. 
     
     
         91 . The intravascular device of  claim 70 , wherein a distal portion of the expandable basket comprises a pre-set conical configuration. 
     
     
         92 . (canceled) 
     
     
         93 . The intravascular device of  claim 70 , wherein the proximally oriented cavity of the expandable basket is configured to be at least partially positioned over an aspiration catheter during an aspiration procedure, wherein the proximally oriented cavity of the expandable basket is configured to cup a distal portion of the aspiration catheter. 
     
     
         94 .- 133 . (canceled)