Delivery systems for control of gastrointestinal bleeding

Abstract

The present disclosure relates to a gastrointestinal delivery device of a dressing, where the delivery device is capable of fitting through a narrow channel before expanding and applying the dressing. The gastrointestinal delivery device may be used in all gastrointestinal bleeding applications and can be used with a biocompatible, foldable, thin profile, chitosan dressing. Various aspects of the device and its uses are provided herein.

1 - 35 . (canceled) 
     
     
         36 . A gastrointestinal delivery device comprising:
 an expandable support; and   a dressing in one of a compact condition, a transition condition, and a splayed condition.   
     
     
         37 . The gastrointestinal delivery device according to  claim 36 , further comprising an axis connected to the expandable support. 
     
     
         38 . The gastrointestinal delivery device according to  claim 36 , wherein a single structure comprises the expandable support and an axis. 
     
     
         39 . The gastrointestinal delivery device according to  claim 36 , further comprising a sheath. 
     
     
         40 . The gastrointestinal delivery device according to  claim 36 , wherein the expandable support is in an unexpanded format and the dressing is in a compact condition. 
     
     
         41 . The gastrointestinal delivery device according to  claim 40 , wherein the dressing is at least one of compacted, closed, folded, furled, or crimped. 
     
     
         42 . The gastrointestinal delivery device according to  claim 36 , wherein the expandable support is in an unexpanded format and the dressing is in a transition condition. 
     
     
         43 . The gastrointestinal delivery device according to  claim 36 , wherein the expandable support is in an expanded format and the dressing is in a splayed condition. 
     
     
         44 . The gastrointestinal delivery device according to  claim 43 , wherein the dressing is at least one of spread out, opened, unfolded, unfurled, uncrimped, or expanded. 
     
     
         45 . The gastrointestinal delivery device according to  claim 43 , wherein the dressing in the splayed condition provides a high surface area. 
     
     
         46 . The gastrointestinal delivery device according to  claim 36 , wherein the dressing may be repeatedly in one of a compact condition, a transition condition, and a splayed condition. 
     
     
         47 . The gastrointestinal delivery device according to  claim 36 , wherein the dressing comprises chitosan. 
     
     
         48 . A method of delivering a dressing to a target tissue site in the gastrointestinal tract using the device according to  claim 36 , comprising:
 a) fitting the expandable support and the dressing into a narrow channel, wherein the dressing is in the compact condition;   b) expanding the expandable support at a target tissue site;   c) applying mechanical force to change the configuration of the dressing from the compact condition to the transition condition or the splayed condition;   d) adhering the dressing to the target tissue site; and   e) removing the expandable support from the target tissue site.   
     
     
         49 . The method of  claim 48 , further comprising adhering the dressing in splayed condition to the target tissue site. 
     
     
         50 . The method of  claim 48 , further comprising applying mechanical force to one or more edges, or the perimeter, of the dressing. 
     
     
         51 . The method of  claim 48 , further comprising applying mechanical force to pull the dressing into a splayed condition or to push the dressing into a splayed condition. 
     
     
         52 . The method of  claim 48 , wherein the expandable support facilitates application of the dressing to the target tissue site. 
     
     
         53 . The method of  claim 48 , wherein the dressing is attached to the delivery device by one or more dressing attachment points able to withstand at least 50 g of load during application of mechanical force to change the configuration of the dressing. 
     
     
         54 . The method of  claim 48 , wherein the dressing is attached to the delivery device by one or more dressing attachment points able to withstand 100 g of load during application of mechanical force to change the configuration of the dressing. 
     
     
         55 . A method of treating gastrointestinal bleeding using the gastrointestinal delivery device according to  claim 36 , comprising:
 a) fitting the expandable support and the dressing into a narrow channel, wherein the dressing is in the compact condition;   b) expanding the expandable support at a target tissue site;   c) applying mechanical force to change the configuration of the dressing from the compact condition to the transition condition or the splayed condition;   d) adhering the dressing to the target tissue site; and   e) removing the expandable support from the target tissue site.