Therapeutic bandage

Abstract

A therapeutic bandage includes a bandage matrix and an array of microneedles extending from the bandage matrix. Each of the microneedles includes a first layer that encapsulates a first immunomodulatory compound and a second layer that encapsulates a second immunomodulatory compound. The array of microneedles is configured to guide foreign agents affected by the first immunomodulatory compound, the second immunomodulatory compound, or the first and second immunomodulatory compounds from one or more skin layers of a user to the bandage matrix such that the bandage matrix absorbs and captures the foreign agents.

1 - 20 . (canceled) 
     
     
         21 . A therapeutic bandage comprising:
 a bandage matrix; and   an array of microneedles extending from the bandage matrix, each of the microneedles including a first layer that encapsulates a first therapeutic agent and a second layer that encapsulates a second therapeutic agent,   wherein the array of microneedles is configured to deliver at least one of the first therapeutic agent or the second therapeutic agent from the bandage matrix into the skin of a patient.   
     
     
         22 . The therapeutic bandage of  claim 21 , wherein the bandage matrix comprises a first bandage layer disposed on a film layer, a second bandage layer disposed on the first bandage layer, and a cellulose layer disposed on the second bandage layer, the array of microneedles protruding from the cellulose layer. 
     
     
         23 . The therapeutic bandage of  claim 21 , wherein the first layer is configured to release the first therapeutic agent at a first rate, and the second layer is configured to release the second therapeutic agent at a second rate that is less than the first rate. 
     
     
         24 . The therapeutic bandage of  claim 21 , wherein the first layer defines a first length and the second layer defines a second length, the first layer being configured to release the first therapeutic agent at a first tissue depth, the second layer being configured to release the second therapeutic agent at a second tissue depth that is different than the first tissue depth. 
     
     
         25 . The therapeutic bandage of  claim 21 , wherein the first layer is formed from a mixture of polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) and the second layer is formed from poly(lactic-co-glycolic acid) (PLGA). 
     
     
         26 . The therapeutic bandage of  claim 21 , wherein at least one of the first therapeutic agent and the second therapeutic agent comprise at least one of an immunomodulatory compound, a biological agent or an antimicrobial agent. 
     
     
         27 . The therapeutic bandage of  claim 26 , wherein the immunomodulatory compound comprises at least one of: chemokines, lipids, N-formylated peptides, eicosinoids, leukotrienes, cytokines, or methylated BSA. 
     
     
         28 . The therapeutic bandage of  claim 26 , wherein the biological agent comprises at least one of an organism specific monoclonal antibody, anti-MecA anti-alpha toxin, or an organism-specific monoclonal antibody. 
     
     
         29 . The therapeutic bandage of  claim 26 , wherein the antimicrobial agent comprises at least one of vancomycin, daptomycin, sitafloxicin, apicidin, savarin, ambuic acid, hydroxyketones, oxacillin, peptide-conjugated locked nucleic acids, tetrapeptide derivatives, ω-hydroxyemodin, or a combination thereof. 
     
     
         30 . A method for fabricating a therapeutic bandage, the method comprising:
 forming a bandage matrix; and   disposing an array of microneedles extending from the bandage matrix, each of the microneedles including a first layer that encapsulates a first therapeutic agent and a second layer that encapsulates a second therapeutic agent, wherein the array of microneedles is configured to deliver at least one of the first agent or the second agent from the bandage matrix into the skin of a patient.   
     
     
         31 . The method of  claim 30 , wherein the forming comprises:
 disposing a first bandage layer on a film layer;   disposing a second bandage layer on an opposing side of the first bandage layer;   disposing a cellulose layer on an opposing side of the second bandage layer; and,   configuring the microneedles to protrude from the cellulose layer.   
     
     
         32 . The method of  claim 30 , further comprising disposing within at least some of the microneedles at least one of an immunomodulatory compound, a biological agent or an antimicrobial agent. 
     
     
         33 . A therapeutic bandage comprising:
 a bandage matrix comprising a first bandage layer disposed on a film layer, a second bandage layer disposed on the first bandage layer and a cellulose layer disposed on the second bandage layer; and   an array of microneedles extending from the cellulose layer of the bandage matrix, each of the microneedles including a first layer that encapsulates a first therapeutic agent and a second layer that encapsulates a second therapeutic agent,   wherein the array of microneedles is configured to deliver at least one of the first therapeutic agent or the second therapeutic agent from the bandage matrix into the skin of a patient.   
     
     
         34 . The therapeutic bandage of  claim 33 , wherein at least one of the first therapeutic agent and the second therapeutic agent comprise at least one of an immunomodulatory compound, a biological agent or an antimicrobial agent.