Transglutaminase treated products

Abstract

The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.

1 . A medical device, comprising:
 a collagen-containing tissue matrix;   a synthetic substrate, wherein the collagen-containing tissue matrix is in contact with the synthetic substrate; and   a region of a surface of the collagen-containing tissue matrix comprising a portion that has been treated with transglutaminase.   
     
     
         2 . The medical device of  claim 1 , wherein the collagen-containing tissue matrix comprises an acellular tissue matrix. 
     
     
         3 . The medical device of  claim 1 , wherein the collagen-containing tissue matrix is produced from tissue derived from skin. 
     
     
         4 . The medical device of  claim 1 , wherein the collagen-containing tissue matrix comprises a dermal tissue matrix. 
     
     
         5 . The medical device of  claim 1 , wherein the device is dry. 
     
     
         6 . The medical device of  claim 11 , wherein the synthetic substrate comprises a synthetic mesh. 
     
     
         7 . The medical device of  claim 1 , wherein the synthetic substrate comprises polypropylene filaments. 
     
     
         8 . The medical device of  claim 1 , wherein the collagen-containing tissue matrix comprises a particulate acellular tissue matrix. 
     
     
         9 . The medical device of  claim 8 , wherein the particulate acellular tissue matrix has been suspended and stabilized to produce a stable three-dimensional shape coating the synthetic substrate. 
     
     
         10 . The medical device of  claim 1 , wherein the collagen-containing tissue matrix coats or encases the synthetic substrate. 
     
     
         11 . The medical device of  claim 1 , wherein the synthetic substrate has a top surface and a bottom surface, the collagen-containing tissue matrix covering the top surface and the bottom surface. 
     
     
         12 . The medical device of  claim 11 , wherein the region of a surface of the collagen-containing tissue matrix comprising a portion that has been treated with transglutaminase is situated on the top surface. 
     
     
         13 . The medical device of  claim 12 , further comprising a second region comprising a portion that has been treated with transglutaminase, the second region situated on the bottom surface. 
     
     
         14 . The medical device of  claim 11 , wherein the region of a surface of the collagen-containing tissue matrix comprising a portion that has been treated with transglutaminase is situated on the bottom surface. 
     
     
         15 . The medical device of  claim 14 , further comprising a second region comprising a portion that has been treated with transglutaminase, the second region situated on the top surface.