Tangential flow cassette-hf emulation

Abstract

A biocompatible polymeric membrane includes pores ( 106 ) defined between two material layers, where the first membrane material layer ( 101 ) includes strips, and the second membrane material ( 104 ) binds to each of the plurality of first membrane material layer strips ( 101 ) includes a plurality of windows ( 105 ) exposing each of the first membrane material strips ( 101 ). The biocompatible polymeric filtration membrane comprises pores ( 106 ) defined by uniform passages defined by the first membrane material layer strips ( 101 ) and the second membrane material layer ( 104 ) within each window ( 105 ).

1 . A biocompatible polymeric filtration membrane comprising:
 a plurality of first membrane material layer strips;   a second membrane material binding to each of the plurality of first membrane material layer strips, the second membrane material comprising a plurality of windows exposing each of the first membrane material strips,   wherein the biocompatible polymeric filtration membrane comprises pores defined by uniform passages defined by the first membrane material layer strips and the second membrane material layer that fluidically connect within each window.   
     
     
         2 . The membrane of  claim 1 , wherein the first membrane material and second membrane material comprise polyimide. 
     
     
         3 . The membrane of  claim 1 , wherein the uniform passages have a thickness of 20 to 1000 nm. 
     
     
         4 . The membrane of  claim 1 , having a thickness in the range of 2-10 microns. 
     
     
         5 . The membrane of  claim 1 , wherein the first membrane layer has a thickness in the range of 1 to 5 microns. 
     
     
         6 . The membrane of  claim 1 , wherein the second membrane layer has a thickness in the range of 2.5 to 20 microns. 
     
     
         7 . The membrane of  claim 1 , having a thickness of 2-10 microns, wherein the first membrane has a thickness in the range of 1 to 5 microns, and the second membrane layer has a thickness in the range of 2.5 to 20 microns. 
     
     
         8 . A method of making a biocompatible polymeric filtration membrane comprising the steps of:
 (a) depositing a first membrane material layer on a substrate;   (b) patterning the first membrane material layer into a plurality of strips;   (c) depositing a pore-defining sacrificial layer on the first membrane material strips;   (d) patterning the pore-defining sacrificial layer into strips orthogonal the first membrane material strips;   (e) depositing a second membrane material layer over the substrate;   (f) etching a window in the second membrane material layer to expose the pore-defining sacrificial layer; and   (g) selectively etching the pore-defining sacrificial layer to create pores defined by uniform passages defined by the first membrane material layer strips and the second membrane material layer within each window.   
     
     
         9 . The method of  claim 8 , wherein the step (b) of patterning the first membrane material layer comprises depositing a hardmask layer on the first membrane material layer. 
     
     
         10 . The method of  claim 8 , wherein the step (f) of etching a window in the second membrane material layer to expose the pore-defining sacrificial layer comprises depositing a hardmask layer on the second membrane material layer. 
     
     
         11 . The method of  claim 8 , wherein the first membrane material and second membrane material comprise polyimide. 
     
     
         12 . The method of  claim 8 , wherein the uniform passages have a thickness of 20 to 1000 nm. 
     
     
         13 . The method of  claim 8 , having a thickness in the range of 2-10 microns. 
     
     
         14 . The method of  claim 8 , wherein the first membrane layer has a thickness in the range of 1 to 5 microns. 
     
     
         15 . The method of  claim 8 , wherein the second membrane layer has a thickness in the range of 2.5 to 20 microns. 
     
     
         16 . The method  claim 8 , wherein the membrane has a thickness of 2-10 microns, the first membrane layer has a thickness in the range of 1 to 5 microns, and the second membrane layer has a thickness in the range of 2.5 to 20 microns.