N-acyl amino acid compounds and methods of use

Abstract

The invention relates to compounds of formula (I): or a salt thereof, wherein R 1 , A, L, and R 2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

1 .- 58 . (canceled) 
     
     
         59 . A method of treating a fibrotic disease in an individual in need thereof comprising administering to the individual a therapeutically effective amount of a compound of formula (I): 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, wherein:
 R 1  is C 6 -C 14  aryl or 5- to 10-membered heteroaryl, wherein the C 6 -C 14  aryl and 5- to 10-membered heteroaryl of R 1  are independently optionally substituted by R 10 ; 
 R 2  is
 5- to 10-membered heteroaryl containing at least 2 ring nitrogen atoms, 
 3- to 12-membered heterocyclyl containing at least 2 ring nitrogen atoms, 
 —NH—R 3 , 
 —R 3 -R 10 , or 
 —R 3 —NR 3a R 3b , 
 
 wherein the 5- to 10-membered heteroaryl and 3- to 12-membered heterocyclyl of R 2  are independently optionally substituted by R 10 ; 
 R 3  is 5- to 10-membered heteroaryl containing at least 1 ring nitrogen atom, or 3- to 12-membered heterocyclyl containing at least 1 ring nitrogen atom, wherein the 5- to 10-membered heteroaryl and 3- to 12-membered heterocyclyl of R 3  are independently optionally substituted by R 10 ; 
 -A-L- is A 3 ; 
 or -A-L- is -A 1 -L 1 - or -A 2 -L 2 -, and R 2  is 5- to 10-membered heteroaryl, 3- to 12-membered heterocyclyl, —NH-(5- to 10-membered heteroaryl), or —NH-(3- to 12-membered heterocyclyl), wherein the 5- to 10-membered heteroaryl and 3- to 12-membered heterocyclyl of R 2  contain at least 2 ring nitrogen atoms and are independently optionally substituted by R 10 ; 
 A 1  is C 3 -C 5  cycloalkylene, C 3 -C 8  cycloalkenylene, C 6 -C 14  arylene, 5- to 10-membered heteroarylene or 3- to 12-membered heterocyclylene, wherein the C 3 -C 8  cycloalkylene, C 3 -C 8  cycloalkenylene, C 6 -C 14  arylene, 5- to 10-membered heteroarylene and 3- to 12-membered heterocyclylene of A 1  are independently optionally substituted by R 10 ; 
 A 2  is C 3 -C 5  alkylene or C 3 -C 5  alkenylene, wherein the C 3 -C 8  alkylene and C 3 -C 8  alkenylene of A 2  are independently optionally substituted by R 9 ; 
 A 3  is C 5 -C 10  alkylene or C 5 -C 10  alkenylene, wherein the C 5 -C 10  alkylene and C 5 -C 10  alkenylene of A 3  are independently optionally substituted by R 9 ; 
 L 1    
 
         is —O—Z—, —O—Z—X 1 —, —O—Y 1 —, —O—Y 1 —X 1 —, —O—Z—Y 1 —, —O—Z—Y 1 —X 1 —, —O—Z—X 1 —Y 1 —, —O—Z—X 1 —Y 1 —X 1 —, —Z—O—Z—, —X 1 —Z—O—Z—, —Z—O—Z—X 1 —, —X 1 —Z—O—Z—X 1 —, —Z—O—Y 1 —, —Z—O—Y 1 —X 1 —, —X 1 —Z—O—Y 1 —, —X 1 —Z—O—Y 1 —X 1 —, —N(R 4 )—Z—, —N(R 4 )—Z—X 1 —, X 2 , —X 2 —Y 1 —, Y 2 , or —Y 2 —X 2 —;
 L 2  is C 3 -C 6  cycloalkylene optionally substituted by R 10 ; 
 each X 1  is independently C 1 -C 6  alkylene or C 2 -C 6  alkenylene, wherein the C 1 -C 6  alkylene and C 2 -C 6  alkenylene of X 1  are independently optionally substituted by R 10 ; 
 each X 2  is independently C 1 -C 6  alkylene or C 2 -C 6  alkenylene, wherein the C 1 -C 6  alkylene and C 2 -C 6  alkenylene of X 2  are independently optionally substituted by R 9 ; 
 each Y 1  is independently C 3 -C 6  cycloalkylene optionally substituted by R 10 ; 
 each Y 2  is independently saturated 3- to 4-membered heterocyclylene optionally substituted by R 10 ; 
 each Z is independently —CR 5a R 5b —; 
 each R 3a , R 3b , R 4 , R 5a  and R 5b  is independently H or C 1 -C 6  alkyl; 
 each R 9  is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, —CN, —OR 11 , —SR 11 , —NR 12 R 13 , —NO 2 , —C═NH(OR 11 ), —C(O)R 11 , —OC(O)R 11 , —C(O)OR 11 , —C(O)NR 12 R 13 , —NR 11 C(O)R 12 , —NR 11 C(O)OR 12 , —NR 11 C(O)NR 12 R 13 , —S(O)R 11 , —S(O) 2 R 11 , —NR 11  S(O)R 12 , —NR 11 S(O) 2 R 12 , —S(O)NR 12 R 13 , —S(O) 2 NR 12 R 13 , —P(O)(OR 12 ) (OR 13 ), C 3 -C 8  cycloalkyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl or C 6 -C 14  aryl, wherein each R 9  is independently optionally substituted by halogen, 
 
         oxo, —OR 14 , —NR 14 R 15 , —C(O)R 14 , —CN, —S(O)R 14 , —S(O) 2 R 14 , —P(O)(OR 14 )(OR 15 ), C 3 -C 5  cycloalkyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, C 6 -C 14  aryl, or C 1 -C 6  alkyl optionally substituted by oxo, —OH or halogen;
 each R 10  is independently oxo or R 9 ; 
 R 11  is independently hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 6 -C 14  aryl, 5- to 6-membered heteroaryl or 3- to 6-membered heterocyclyl, wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 6 -C 14  aryl, 5- to 6-membered heteroaryl and 3- to 6-membered heterocyclyl are independently optionally substituted by halogen, oxo, —CN, —OR 16 , —NR 16 R 17 , —P(O)(OR 16 )(OR 17 ), or C 1 -C 6  alkyl optionally substituted by halogen, —OH or oxo; 
 R 12  and R 13  are each independently hydrogen, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 6 -C 14  aryl, 5- to 6-membered heteroaryl or 3- to 6-membered heterocyclyl, wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 6 -C 14  aryl, 5- to 6-membered heteroaryl and 3- to 6-membered heterocyclyl are independently optionally substituted by halogen, oxo, —CN, —OR 16 , —NR 16 R 17  or C 1 -C 6  alkyl optionally substituted by halogen, —OH or oxo;
 or R 12  and R 13  are taken together with the atom to which they attached to form a 3- to 6-membered heterocyclyl optionally substituted by halogen, oxo, —OR 16 , —NR 16 R 17  or C 1 -C 6  alkyl optionally substituted by halogen, oxo or —OH; 
 
 R 14  and R 15  are each independently hydrogen, C 1 -C 6  alkyl optionally substituted by halogen or oxo, C 2 -C 6  alkenyl optionally substituted by halogen or oxo, or C 2 -C 6  alkynyl optionally substituted by halogen or oxo;
 or R 14  and R 15  are taken together with the atom to which they attached to form a 3- to 6-membered heterocyclyl optionally substituted by halogen, oxo or C 1 -C 6  alkyl optionally substituted by halogen or oxo; and 
 
 R 16  and R 17  are each independently hydrogen, C 1 -C 6  alkyl optionally substituted by halogen or oxo, C 2 -C 6  alkenyl optionally substituted by halogen or oxo, or C 2 -C 6  alkynyl optionally substituted by halogen or oxo;
 or R 16  and R 17  are taken together with the atom to which they attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo or C 1 -C 6  alkyl optionally substituted by oxo or halogen; 
 
 provided that the compound is other than: 
 
         L-Tyrosine, N-[(5-chloro-1,3-benzodioxol-4-yl)carbonyl]-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, N-[(3-chloro-1-methyl-1H-indol-2-yl)carbonyl]-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, N-[[1-cyclohexyl-2-(3-furanyl)-1H-benzimidazol-5-yl]carbonyl]-O-(1H-tetrazol-5-ylmethyl)-; 
         L-Tyrosine, N-(2,6-dichlorobenzoyl)-O-[(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)methyl]-; 
         L-Tyrosine, N-(2-chloro-4-methoxybenzoyl)-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         L-Tyrosine, N-(2-chloro-6-methylbenzoyl)-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         L-Tyrosine, N-(2-fluoro-6-methylbenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, N-[(2-ethyl-3-thienyl)carbonyl]-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tryptophan, N-benzoyl-5-[4-(1-piperazinyl)butoxyl-; 
         L-Tyrosine, N-(2-chlorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, N-[(3-chloro-2-thienyl)carbonyl]-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         2-Pyridinepropanoic acid, a-[(2,6-dichlorobenzoyl)amino]-5-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2-chloro-6-fluorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-Tyrosine, N-[(3-chloro-4-pyridinyl)carbonyl]-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         L-Tyrosine, O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-N-(2,4,6-trimethylbenzoyl)-; 
         L-Tyrosine, N-[(3,5-dichloro-4-pyridinyl)carbonyl]-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         L-Tyrosine, N-(2,4-dichlorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         2-Pyridinepropanoic acid, α-[(2-chloro-4-methoxybenzoyl)amino]-5-[2(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         2-Pyridinepropanoic acid, α-[(2-chlorobenzoyl)amino]-5-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2-chloro-6-fluoro-3-methylbenzoyl)-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         3-Pyridinepropanoic acid, α-[(2-chlorobenzoyl)amino]-6-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2,6-dichlorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, N-(2-chloro-6-fluorobenzoyl)-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         L-Tyrosine, N-(2-chloro-5-fluorobenzoyl)-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         2-Naphthalenepropanoic acid, α-(benzoylamino)-6-[2-(1-piperazinyl)ethoxy]-; 
         L-Tyrosine, O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-N-(2-ethyl-4-fluorobenzoyl)-; 
         L-Tyrosine, N-(2,6-dichlorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-5-methyl-1,8-naphthyridin-2-yl)ethyl]-; 
         2-Pyridinepropanoic acid, α-[[(3-chloro-2-thienyl)carbonyl]amino]-5-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2,6-dichlorobenzoyl)-O-[2-(1,2,3,4-tetrahydro-1-methylpyrido[2,3-b]pyrazin-6-yl)ethyl]-; 
         L-Tryptophan, N-benzoyl-5-[3-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]propoxy]-; 
         L-Tyrosine, N-(2,6-dimethylbenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-N-[(3-methyl-4-pyridinyl)carbonyl]-; 
         L-Tyrosine, N-(2-chloro-6-methylbenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, N-[(3-chloro-2-thienyl)carbonyl]-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         2-Thiophenepropanoic acid, α-[[(3,5-dichloro-4-pyridinyl)carbonyl]amino]-5-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2-chloro-3,6-difluorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         2-Pyridinepropanoic acid, α-[(2-fluoro-4-methylbenzoyl)amino]-5-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2,6-dichlorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-4-methyl-1,8-naphthyridin-2-yl)ethyl]-; 
         2-Pyridinepropanoic acid, α-[(2-chloro-4-fluorobenzoyl)amino]-5-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2,6-dichlorobenzoyl)-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         3-Pyridinepropanoic acid, α-[(2-chloro-4-fluorobenzoyl)amino]-6-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2-chlorobenzoyl)-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         L-Tyrosine, O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-N-(2-ethyl-5-fluorobenzoyl)-; 
         1-Piperazinecarboxylic acid, 4-[2-[[6-[2-(benzoylamino)-2-carboxyethyl]-2-naphthalenyl]oxy]ethyl]-, 1-(1,1-dimethylethyl) ester; 
         L-Tyrosine, O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-N-(2,4,6-trimethylbenzoyl)-; 
         L-Tyrosine, O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-N-(2,6-dimethylbenzoyl)-; 
         3-Pyridinepropanoic acid, α-[[(3-chloro-2-thienyl)carbonyl]amino]-6-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tryptophan, N-benzoyl-5-[4-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]butoxy]-; 
         L-Tyrosine, N-(2-methylbenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, N-[(3,5-dichloro-4-pyridinyl)carbonyl]-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tryptophan, N-benzoyl-5-[3-(1-piperazinyl)propoxy]-; 
         L-Tyrosine, N-(6-chloro-2-fluoro-3-methylbenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, N-[(4-methoxy-3-thienyl)carbonyl]-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         L-Tyrosine, N-(2-chloro-4-fluorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-L-Tyrosine, O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-N-[(3,5-dimethyl-4-isoxazolyl)carbonyl]-; 
         L-Tyrosine, N-(2-chloro-5-methylbenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-; 
         2-Pyridinepropanoic acid, α-[(2-ethyl-4-fluorobenzoyl)amino]-5-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, αS)-; 
         L-Tyrosine, N-(2,6-dichlorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-7-methyl-1,8-naphthyridin-2-yl)ethyl]-; 
         2-Pyridinepropanoic acid, α-[(2-chloro-6-fluorobenzoyl)amino]-5-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxyl-, (αS)-; 
         3-Pyridinepropanoic acid, α-(2-chloro-6-fluorobenzoyl)amino]-6-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2-chloro-4-fluorobenzoyl)-O-[2-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)ethyl]-; 
         3-Pyridinepropanoic acid, α-[(2,6-dichlorobenzoyl)amino]-6-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]-, (αS)-; 
         L-Tyrosine, N-(2,6-dichlorobenzoyl)-O-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]; 
         L-Tyrosine, N-(2,6-dichlorobenzoyl)-O-[2-methyl-2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-; 
         L-Tyrosine, O-[3-(4-pyrimidinylamino)propyl]-N-(2,4,6-trimethylbenzoyl)-; 
         L-Tyrosine, N-benzoyl-O-[4-[(1,4,5,6-tetrahydro-2-pyrimidinyl)amino]butyl]-; 
         L-Tyrosine, O-[2-(2-benzothiazolylamino)ethyl]-N-(2,6-dichlorobenzoyl)-; 
         L-Tyrosine, O-[3-[(1,4,5,6-tetrahydro-2-pyrimidinyl)amino]propyl]-N-(2,4,6-trimethylbenzol)-; 
         L-Tyrosine, O-[3-(2-pyrimidinylamino)propyl]-N-(2,4,6-trimethylbenzoyl)-; 
         L-Tyrosine, O-[2-(1H-benzimidazol-2-ylamino)ethyl]-N-(2,6-dichlorobenzoyl)-; 
         L-Tyrosine, N-benzoyl-O-[4-(2-pyrimidinylamino)butyl]-; 
         L-Tyrosine, O-[3-[(1,4,5,6-tetrahydro-2-pyrazinyl)amino]propyl]-N-(2,4,6-trimethylbenzoyl)-; 
         L-Tyrosine, O-[3-(2-pyrazinylamino)propyl]-N-(2,4,6-trimethylbenzol)-; 
         2-Thiophenepropanoic acid, α-[(2-chloro-4-fluorobenzoyl)amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         2-Pyridinepropanoic acid, α-[(2-chlorobenzoyl)amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         3-Pyridinepropanoic acid, α-[(2-chloro-4-fluorobenzoyl)amino]-6-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         2-Thiophenepropanoic acid, α-[[(3,5-dichloro-4-pyridinyl)carbonyl]amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         L-Phenylalanine, N-(2-chloro-4-fluorobenzoyl)-4-[3-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)propyl]-; 
         2-Thiophenepropanoic acid, α-[(2-chloro-6-fluorobenzoyl)amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl], (αS)-; 
         2-Pyridinepropanoic acid, α-[(2-fluoro-6-methylbenzoyl)amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         3-Pyridinepropanoic acid, α-[(2-chloro-6-fluorobenzoyl)amino]-6-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl-, (αS)-; 
         L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[3-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)propyl]-; 
         2-Thiophenepropanoic acid, α-(2,6-dichlorobenzoyl)amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl-, (αS)-; 
         2-Pyridinepropanoic acid, α-(2-chloro-4-fluorobenzoyl)amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         2-Pyridinepropanoic acid, α-[[(3-chloro-2-thienyl)carbonyl]amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         L-Phenylalanine, N-(2-chlorobenzoyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-; 
         L-Phenylalanine, N-(2-chloro-6-fluorobenzoyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-; 
         2-Pyridinepropanoic acid, α-[(2-chloro-6-fluorobenzoyl)amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         2-Pyridinepropanoic acid, α-[(2,6-dichlorobenzoyl)amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-; 
         3-Pyridinepropanoic acid, α-[(2,6-dichlorobenzoyl)amino]-6-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         L-Phenylalanine, N-[(3,5-dimethyl-4-isoxazolyl)carbonyl]-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-; 
         L-Phenylalanine, N-(2-chlorobenzoyl)-4-[3-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)propyl]-; 
         2-Thiophenepropanoic acid, α-[[3-[(dimethylamino)methyl]benzoyl]amino]-5-[(8-methyl-6,10-dioxo-7,9-diazaspiro[4.5]dec-7-en-9-yl)methyl]-; 
         2-Thiophenepropanoic acid, α-[(2-chlorobenzoyl)amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         L-Phenylalanine, N-(2-chloro-4-fluorobenzoyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-; 
         3-Pyridinepropanoic acid, α-[(2-chlorobenzoyl)amino]-6-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         2-Thiophenepropanoic acid, α-[[(3,5-dimethyl-4-isoxazolyl)carbonyl]amino]-5-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; 
         L-Phenylalanine, N-(2-chloro-6-fluorobenzoyl)-4-[3-(3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-6-yl)propyl]-; 
         3-Pyridinepropanoic acid, α-[[(3-chloro-2-thienyl)carbonyl]amino]-6-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-, (αS)-; or 
         1,8-Naphthyridine-2-nonanoic acid, α-(benzoylamino)-5,6,7,8-tetrahydro-, (αS)-, 
         or a pharmaceutically acceptable salt thereof, and
 wherein the fibrotic disease is selected from the group consisting of: idiopathic pulmonary fibrosis, cirrhosis, biliary tract fibrosis, diabetic nephrosclerosis, hypertensive nephrosclerosis, focal segmental glomerulosclerosis, acute kidney injury from contrast induced nephropathy, systemic and local sclerosis or scleroderma, keloids and hypertrophic scars, post-surgical adhesions, atherosclerosis, restenosis, Crohn's disease, post-myocardial infarction induced fibrosis, and inherited cardiomyopathy. 
 
       
     
     
         60 . The method of  claim 59 , wherein R 1  is a fused bicyclic C 9 -C 14  aryl optionally substituted by R 10  or a fused bicyclic 7- to 10-membered heteroaryl optionally substituted by R 10 . 
     
     
         61 . The method of  claim 60 , wherein R 1  is the fused bicyclic 7- to 10-membered heteroaryl optionally substituted by R 10 , and wherein R 1  is indazolyl optionally substituted by R 10 , benzimidazolyl optionally substituted by R 10 , or benzoxazolyl optionally substituted by R 10 . 
     
     
         62 . The method of  claim 59 , wherein R 1  is phenyl optionally substituted by R 10 . 
     
     
         63 . The method of  claim 59 , wherein R 1  is a monocyclic 5- or 6-membered heteroaryl optionally substituted by R 10 . 
     
     
         64 . The method of  claim 59 , wherein the -A-L-moiety is -A 1 -L 1 -. 
     
     
         65 . The method of  claim 64 , wherein A 1  is selected from the group consisting of: 1,4-phenylene, 1,3-phenylene, 1,1-cyclopropylene, 1,2-cyclopropylene, 1,3-cyclobutylene, 1,4-cyclohexylene, 1,3-azetidinylene, 1,3-pyrrolidinylene, and 2,5-benzo[d]oxazolylene. 
     
     
         66 . The method of  claim 64 , wherein L 1    is —O—Z—, —O—Z—X 1 —, —O—Y 1 —, —O—Z—Y 1 —, —O—Z—X 1 —Y 1 —, —Z—O—Z—, —X 1 —Z—O—Z—, —Z—O—Z—X 1 —, —X 1 —Z—O—Z—X 1 —, —Z—O—Y 1 —, or —X 1 —Z—O—Y 1 —.   
     
     
         67 . The method of  claim 66 , wherein Z is —CR 5a R 5b —, and wherein each of R 5a  and R 5b  is independently H. 
     
     
         68 . The method of  claim 66 , wherein L 1  is selected from the group consisting of: —O—(CH 2 ) 3 —, —O—(CH 2 ) 4 —, —CH 2 —O—(CH 2 ) 3 —, —CH 2 —O—(CH 2 ) 2 —, —CH(CH 3 )—O—(CH 2 ) 2 —, —CH 2 —O—(C H 2 ) 3 —, 
       
         
           
           
               
               
           
         
       
       and wherein the wavy lines denote attachment points to the parent molecule. 
     
     
         69 . The method of  claim 64 , wherein L 1  is —N(R 4 )—Z— or —N(R 4 )—Z—X 1 —. 
     
     
         70 . The method of  claim 69 , wherein R 4  is H and Z is —CR 5a R 5b —, wherein each of R 5a  and R 5b  is independently H, and wherein L 1  is —NH—C(CH 3 ) 2 —(CH 2 ) 2 —. 
     
     
         71 . The method of  claim 64 , wherein L 1  is X 2  or —X 2 —Y 1 —, wherein L 1  is selected from the group consisting of: —(CH 2 ) 2 —, —(CH 2 ) 4 —, —(CH 2 ) 5 —, —CF 2 —(CH 2 ) 3 — and 
       
         
           
           
               
               
           
         
       
       and wherein the wavy lines denote attachment points to the parent molecule. 
     
     
         72 . The method of  claim 64 , wherein L 1  is Y 2  or —Y 2 —X 2 —. 
     
     
         73 . The method of  claim 72 , wherein Y 2  is saturated 4-membered heterocyclylene optionally substituted by R 10 . 
     
     
         74 . The method of  claim 72 , wherein L 1  is selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
       and wherein the wavy lines denote attachment points to the parent molecule. 
     
     
         75 . The method of  claim 59 , wherein the -A-L- moiety is -A 2 -L 2 -, and wherein A 2  is C 3 -C 8  alkylene optionally substituted by R 9 . 
     
     
         76 . The method of  claim 59 , wherein the -A-L- moiety is A 3 , and wherein A 3  is C 5 -C 10  alkenylene optionally substituted by R 9 . 
     
     
         77 . The method of  claim 59 , wherein the -A-L- moiety is -A 2 -L 2 - or A 3 , wherein the -A-L-moiety is selected from the group consisting of: —CH 2 (CH 2 ) 5 CH 2 —, —CH 2 (CH 2 ) 4 CH 2 —, —CH═CH—(CH 2 ) 3 CH 2 —, and 
       
         
           
           
               
               
           
         
       
       and wherein the wavy lines denote attachment points to the parent molecule. 
     
     
         78 . The method of  claim 59 , wherein R 2  is 5- to 10-membered heteroaryl containing at least 2 ring nitrogen atoms optionally substituted by R 10 , or 3- to 12-membered heterocyclyl containing at least 2 ring nitrogen atoms optionally substituted by R 10 . 
     
     
         79 . The method of  claim 78 , wherein R 2  is selected from the group consisting of: 5,6,7,8-tetrahydro-naphthyridinyl, 1,2,3,4-tetrahydro-1,8-naphthyridinyl, 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazinyl, and 2,3-dihydro-1H-pyrrolo[2,3-b]pyridinyl. 
     
     
         80 . The method of  claim 59 , wherein R 2  is —NH—R 3  and -A-L- is -A 3 -. 
     
     
         81 . The method of  claim 80 , wherein R 3  is 5- to 10-membered heteroaryl containing at least 1 ring nitrogen atom optionally substituted by R 10 , and wherein R 3  is selected from the group consisting of: 4,5-dihydro-1H-imidazolyl, 5,6-dihydro-4H-1,3-oxazinyl, 4,5-dihydrothiazolyl, 3,4,5,6-tetrahydropyrazinyl, and 5,6-dihydro-4H-1,3-thiazinyl. 
     
     
         82 . The method of  claim 80 , wherein R 3  is pyridinyl optionally substituted by R 10 , and wherein R 3  is selected from the group consisting of: 4,5-dihydro-1H-imidazolyl, 5,6-dihydro-4H-1,3-oxazinyl, 4,5-dihydrothiazolyl, 3,4,5,6-tetrahydropyrazinyl, and 5,6-dihydro-4H-1,3-thiazinyl. 
     
     
         83 . The method of  claim 59 , wherein R 2 —R 3 —NR 3a R 3b  and -A-L- is -A 3 -. 
     
     
         84 . The method of  claim 83 , wherein R 2  is —R 3 —NHR 3a . 
     
     
         85 . The method of  claim 83 , wherein R 3  is pyridyl optionally substituted by R 10 . 
     
     
         86 . The method of  claim 59 , wherein the compound is selected from the group consisting of:
 2-benzamido-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-benzamido-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-benzamido-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(1-methyl-1H-benzo[d]imidazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(1-methyl-1H-benzo[d]imidazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(1-methyl-1H-benzo[d]imidazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(5-(difluoromethyl)pyrazine-2-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(5-(difluoromethyl)pyrazine-2-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(5-(difluoromethyl)pyrazine-2-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(6-phenylpyrazine-2-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(6-phenylpyrazine-2-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(6-phenylpyrazine-2-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2,6-dichloro-4-cyanobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichloro-4-cyanobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichloro-4-cyanobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2-fluoro-6-(trifluoromethyl)benzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(2-fluoro-6-(trifluoromethyl)benzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(2-fluoro-6-(trifluoromethyl)benzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2,6-difluorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(2,6-difluorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(2,6-difluorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2-methylpyrimidine-4-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(2-methylpyrimidine-4-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(2-methylpyrimidine-4-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(1-methyl-1H-benzo[d]imidazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(1-methyl-1H-benzo[d]imidazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(1-methyl-1H-benzo[d]imidazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(benzo[d]oxazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(benzo[d]oxazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(benzo[d]oxazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(3-amino-4-hydroxybenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(3-amino-4-hydroxybenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(3-amino-4-hydroxybenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(3-formamido-4-hydroxybenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(3-formamido-4-hydroxybenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(3-formamido-4-hydroxybenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(isonicotinamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(isonicotinamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(isonicotinamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(nicotinamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(nicotinamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(nicotinamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(3,5-dichloroisonicotinamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(3,5-dichloroisonicotinamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(3,5-dichloroisonicotinamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(4-((4-methyl-3-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(4-((4-methyl-3-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(4-((4-methyl-3-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(3-((S)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(3-((R)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(3-((R)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-yl)propoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(3-((S)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(2,6-dichlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (R)-2-(2,6-dichlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (E)-2-(2,6-dichlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)non-4-enoic acid;   (S, E)-2-(2,6-dichlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)non-4-enoic acid;   (R, E)-2-(2,6-dichlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)non-4-enoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(3-((5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)methyl)azetidin-1-yl)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(3-((5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)methyl)azetidin-1-yl)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(3-((5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)methyl)azetidin-1-yl)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)azetidin-1-yl)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)azetidin-1-yl)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)azetidin-1-yl)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-((3-(pyridin-2-ylamino)cyclobutyl)methoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-((3-(pyridin-2-ylamino)cyclobutyl)methoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-((3-(pyridin-2-ylamino)cyclobutyl)methoxy)phenyl)propanoic acid;   (E)-2-(2,6-dichlorobenzamido)-3-(4-(2-(4-(pyridin-3-ylamino)cyclohexyl)vinyl)phenyl)propanoic acid;   (S, E)-2-(2,6-dichlorobenzamido)-3-(4-(2-(4-(pyridin-3-ylamino)cyclohexyl)vinyl)phenyl)propanoic acid;   (R, E)-2-(2,6-dichlorobenzamido)-3-(4-(2-(4-(pyridin-3-ylamino)cyclohexyl)vinyl)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-((4-(pyridin-2-ylamino)cyclohexyl)methoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-((4-(pyridin-2-ylamino)cyclohexyl)methoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-((4-(pyridin-2-ylamino)cyclohexyl)methoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-((2-methyl-4-(pyridin-2-ylamino)butan-2-yl)amino)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-((2-methyl-4-(pyridin-2-ylamino)butan-2-yl)amino)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-((2-methyl-4-(pyridin-2-ylamino)butan-2-yl)amino)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(3-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-3-(4-(3-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-3-(4-(3-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (+/−)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)azetidin-1-yl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)azetidin-1-yl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)azetidin-1-yl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-((2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy)methyl)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-((2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy)methyl)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-((2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy)methyl)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-((3-(pyridin-2-ylamino)propoxy)methyl)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-((3-(pyridin-2-ylamino)propoxy)methyl)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-((3-(pyridin-2-ylamino)propoxy)methyl)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(((4-(pyridin-2-ylamino)cyclohexyl)oxy)methyl)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(((4-(pyridin-2-ylamino)cyclohexyl)oxy)methyl)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(((4-(pyridin-2-ylamino)cyclohexyl)oxy)methyl)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-((3-(pyridin-2-ylamino)cyclobutoxy)methyl)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-((3-(pyridin-2-ylamino)cyclobutoxy)methyl)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-((3-(pyridin-2-ylamino)cyclobutoxy)methyl)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(1-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy)ethyl)phenyl)propanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-3-(4-(1-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy)ethyl)phenyl)propanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-3-(4-(1-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy)ethyl)phenyl)propanoic acid;   2-(4-cyclopropylbenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(4-cyclopropylbenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(4-cyclopropylbenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(3,5-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(3,5-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(3,5-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2-chloro-5-fluorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(2-chloro-5-fluorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(2-chloro-5-fluorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-[(2,6-dichlorobenzoyl)amino]-3-[4-[4-cis-(2-pyridylamino)cyclohexoxy]phenyl]propanoic acid;   (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-[4-cis-(2-pyridylamino)cyclohexoxy]phenyl]propanoic acid;   (2R)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-[4-cis-(2-pyridylamino)cyclohexoxy]phenyl]propanoic acid;   2-[(2,6-dichlorobenzoyl)amino]-3-[4-[4-trans-(2-pyridylamino)cyclohexoxy]phenyl]propanoic acid;   (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-[4-trans-(2-pyridylamino)cyclohexoxy]phenyl]propanoic acid;   (2R)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-[4-trans-(2-pyridylamino)cyclohexoxy]phenyl]propanoic acid;   2-(1H-indazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(1H-indazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(1H-indazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(1-methyl-1H-indazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(1-methyl-1H-indazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(1-methyl-1H-indazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(1H-indazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(1H-indazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(1H-indazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(1-methyl-1H-indazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(1-methyl-1H-indazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(1-methyl-1H-indazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2-methyl-2H-indazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(2-methyl-2H-indazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(2-methyl-2H-indazole-6-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2-methyl-2H-indazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(2-methyl-2H-indazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(2-methyl-2H-indazole-5-carboxamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-((1-((pyridin-2-ylamino)methyl)cyclopropyl)methoxy)phenyl)propanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-3-(4-((1-((pyridin-2-ylamino)methyl)cyclopropyl)methoxy)phenyl)propanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-3-(4-((1-((pyridin-2-ylamino)methyl)cyclopropyl)methoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-10-((3,4,5,6-tetrahydropyrazin-2-yl)amino)decanoic acid;   (S)-2-(2,6-dichlorobenzamido)-10-((3,4,5,6-tetrahydropyrazin-2-yl)amino)decanoic acid;   (R)-2-(2,6-dichlorobenzamido)-10-((3,4,5,6-tetrahydropyrazin-2-yl)amino)decanoic acid;   2-(2,6-dichlorobenzamido)-10-((4,5-dihydrooxazol-2-yl)amino)decanoic acid;   (S)-2-(2,6-dichlorobenzamido)-10-((4,5-dihydrooxazol-2-yl)amino)decanoic acid;   (R)-2-(2,6-dichlorobenzamido)-10-((4,5-dihydrooxazol-2-yl)amino)decanoic acid;   2-(2,6-dichlorobenzamido)-10-((4,5-dihydrothiazol-2-yl)amino)decanoic acid;   (S)-2-(2,6-dichlorobenzamido)-10-((4,5-dihydrothiazol-2-yl)amino)decanoic acid;   (R)-2-(2,6-dichlorobenzamido)-10-((4,5-dihydrothiazol-2-yl)amino)decanoic acid;   2-(2,6-dichlorobenzamido)-10-((1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)decanoic acid;   (S)-2-(2,6-dichlorobenzamido)-10-((1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)decanoic acid;   (R)-2-(2,6-dichlorobenzamido)-10-((1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)decanoic acid;   2-(2,6-dichlorobenzamido)-10-((5,6-dihydro-4H-1,3-oxazin-2-yl)amino)decanoic acid;   (S)-2-(2,6-dichlorobenzamido)-10-((5,6-dihydro-4H-1,3-oxazin-2-yl)amino)decanoic acid;   (R)-2-(2,6-dichlorobenzamido)-10-((5,6-dihydro-4H-1,3-oxazin-2-yl)amino)decanoic acid;   2-(2,6-dichlorobenzamido)-10-((4-methyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)decanoic acid;   (S)-2-(2,6-dichlorobenzamido)-10-((4-methyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)decanoic acid;   (R)-2-(2,6-dichlorobenzamido)-10-((4-methyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)decanoic acid;   2-(2,6-dichlorobenzamido)-10-((4-methyl-3-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)decanoic acid;   (S)-2-(2,6-dichlorobenzamido)-10-((4-methyl-3-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)decanoic acid;   (R)-2-(2,6-dichlorobenzamido)-10-((4-methyl-3-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)decanoic acid;   2-(2,6-dichlorobenzamido)-10-((5,6-dihydro-4H-1,3-thiazin-2-yl)amino)decanoic acid;   (S)-2-(2,6-dichlorobenzamido)-10-((5,6-dihydro-4H-1,3-thiazin-2-yl)amino)decanoic acid;   (R)-2-(2,6-dichlorobenzamido)-10-((5,6-dihydro-4H-1,3-thiazin-2-yl)amino)decanoic acid;   3-(4-(4-((4-acetyl-3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)-2-(2,6-dichlorobenzamido)propanoic acid;   (S)-3-(4-(4-((4-acetyl-3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)-2-(2,6-dichlorobenzamido)propanoic acid;   (R)-3-(4-(4-((4-acetyl-3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)-2-(2,6-dichlorobenzamido)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(4-((3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(4-((3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(4-((3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(4-((1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)butoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(4-((1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)butoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(4-((1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)butoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(4-((4-methyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(4-((4-methyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(4-((4-methyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)amino)butoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(4-((5,6-dihydro-4H-1,3-oxazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(4-((5,6-dihydro-4H-1,3-oxazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(4-((5,6-dihydro-4H-1,3-oxazin-2-yl)amino)butoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(4-((5,6-dihydro-4H-1,3-thiazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(4-((5,6-dihydro-4H-1,3-thiazin-2-yl)amino)butoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(4-((5,6-dihydro-4H-1,3-thiazin-2-yl)amino)butoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(4-((4,5-dihydrooxazol-2-yl)amino)butoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(4-((4,5-dihydrooxazol-2-yl)amino)butoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(4-((4,5-dihydrooxazol-2-yl)amino)butoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(4-((4,5-dihydrothiazol-2-yl)amino)butoxy)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(4-((4,5-dihydrothiazol-2-yl)amino)butoxy)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(4-((4,5-dihydrothiazol-2-yl)amino)butoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(3-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-3-(4-(3-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-3-(4-(3-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)propoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(3-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-3-(4-(3-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-3-(4-(3-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   2-(2,6-dichlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(2,6-dichlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (R)-2-(2,6-dichlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(2,6-dichlorobenzamido)-9-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)nonanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-9-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)nonanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-9-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)nonanoic acid;   2-(2,6-dichlorobenzamido)-7-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)cyclopropyl)heptanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-7-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)cyclopropyl)heptanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-7-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)cyclopropyl)heptanoic acid;   2-(2,6-dichlorobenzamido)-3-(2-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)cyclopropyl)propanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-3-(2-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)cyclopropyl)propanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-3-(2-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)cyclopropyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(1-(5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentyl)cyclopropyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(1-(5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentyl)cyclopropyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(1-(5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentyl)cyclopropyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)cyclobutyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)cyclobutyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)cyclobutyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(3-((3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)methyl)cyclobutyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(3-((3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)methyl)cyclobutyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(3-((3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)methyl)cyclobutyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)cyclohexyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)cyclohexyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)cyclohexyl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(3-((3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)methyl)azetidin-1-yl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(3-((3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)methyl)azetidin-1-yl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(3-((3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)methyl)azetidin-1-yl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)azetidin-1-yl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)azetidin-1-yl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)azetidin-1-yl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)pyrrolidin-1-yl)propanoic acid;   (2S)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)pyrrolidin-1-yl)propanoic acid;   (2R)-2-(2,6-dichlorobenzamido)-3-(3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)pyrrolidin-1-yl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(2-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)benzo[d]oxazol-5-yl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(2-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)benzo[d]oxazol-5-yl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(2-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)benzo[d]oxazol-5-yl)propanoic acid;   2-(2,6-dichlorobenzamido)-3-(4-(1,1-difluoro-4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)phenyl)propanoic acid;   (S)-2-(2,6-dichlorobenzamido)-3-(4-(1,1-difluoro-4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)phenyl)propanoic acid;   (R)-2-(2,6-dichlorobenzamido)-3-(4-(1,1-difluoro-4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)phenyl)propanoic acid;   9-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)-2-(1-methyl-1H-indazole-5-carboxamido)nonanoic acid;   (2S)-9-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)-2-(1-methyl-1H-indazole-5-carboxamido)nonanoic acid;   (2R)-9-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)-2-(1-methyl-1H-indazole-5-carboxamido)nonanoic acid;   2-(1-methyl-1H-indazole-5-carboxamido)-9-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (2S)-2-(1-methyl-1H-indazole-5-carboxamido)-9-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (2R)-2-(1-methyl-1H-indazole-5-carboxamido)-9-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   9-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)-2-(1-methyl-1H-indazole-6-carboxamido)nonanoic acid;   (2S)-9-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)-2-(1-methyl-1H-indazole-6-carboxamido)nonanoic acid;   (2R)-9-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-yl)-2-(1-methyl-1H-indazole-6-carboxamido)nonanoic acid;   2-(1-methyl-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1-methyl-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (R)-2-(1-methyl-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(1-methyl-1H-indazole-5-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1-methyl-1H-indazole-5-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (R)-2-(1-methyl-1H-indazole-5-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(1-(tert-butyl)-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1-(tert-butyl)-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (R)-2-(1-(tert-butyl)-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(1-(cyclopropylmethyl)-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1-(cyclopropylmethyl)-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (R)-2-(1-(cyclopropylmethyl)-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(2-methyl-2H-indazole-5-carboxamido)-9-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (2S)-2-(2-methyl-2H-indazole-5-carboxamido)-9-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (2R)-2-(2-methyl-2H-indazole-5-carboxamido)-9-(1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(2-methyl-2H-indazole-5-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(2-methyl-2H-indazole-5-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (R)-2-(2-methyl-2H-indazole-5-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(4-chlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(4-fluorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(4-methoxybenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(4-cyanobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(3-chlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(3-fluorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(3-methoxybenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(3-cyanobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(2-fluorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(2-chlorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-2-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxamido)nonanoic acid;   2-(1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   2-(2,6-dichloro-4-(1H-imidazol-5-yl)benzamido)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propoxy)phenyl)propanoic acid;   (S)-2-(2-chloro-5-cyanobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(4-cyano-2-fluorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1H-indazole-5-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1-(difluoromethyl)-1H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(2-(difluoromethyl)-2H-indazole-5-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1-(difluoromethyl)-1H-indazole-5-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(2-(difluoromethyl)-2H-indazole-6-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(5-phenyl-1H-pyrazole-4-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(4-(pyridin-3-yl)benzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(4-(pyridin-4-yl)benzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(4-(1-methyl-1H-pyrazol-4-yl)benzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1-methyl-1H-indazole-7-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1-methyl-1H-indazole-4-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(1H-indazole-4-carboxamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(2-chloro-4-isopropoxybenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(2-chloro-5-(trifluoromethoxy)benzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(3-(3,5-dimethyl-1H-pyrazol-1-yl)benzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-benzamido-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(2-chloro-3-fluorobenzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (S)-2-(3-fluoro-5-(trifluoromethyl)benzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (R)-2-(3-(1-methyl-1H-pyrazol-4-yl)benzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid;   (R)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-2-(3-(thiazol-5-yl)benzamido)nonanoic acid;   (R)-2-(3-fluoro-5-(trifluoromethyl)benzamido)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid; and   (S)-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-2-(3-(thiazol-5-yl)benzamido)nonanoic acid,   
       or a pharmaceutically acceptable salt thereof. 
     
     
         87 . The method of  claim 59 , wherein the fibrotic disease is idiopathic pulmonary fibrosis. 
     
     
         88 . The method of  claim 59 , wherein the fibrotic disease is cirrhosis. 
     
     
         89 . The method of  claim 59 , wherein the fibrotic disease is biliary tract fibrosis. 
     
     
         90 . The method of  claim 59 , wherein the fibrotic disease is diabetic nephrosclerosis. 
     
     
         91 . The method of  claim 59 , wherein the fibrotic disease is hypertensive nephrosclerosis. 
     
     
         92 . The method of  claim 59 , wherein the fibrotic disease is focal segmental glomerulosclerosis. 
     
     
         93 . The method of  claim 59 , wherein the fibrotic disease is acute kidney injury from contrast induced nephropathy. 
     
     
         94 . The method of  claim 59 , wherein the fibrotic disease is systemic and local sclerosis or scleroderma. 
     
     
         95 . The method of  claim 59 , wherein the fibrotic disease is keloids and hypertrophic scars. 
     
     
         96 . The method of  claim 59 , wherein the fibrotic disease is post-surgical adhesions. 
     
     
         97 . The method of  claim 59 , wherein the fibrotic disease is atherosclerosis. 
     
     
         98 . The method of  claim 59 , wherein the fibrotic disease is restenosis. 
     
     
         99 . The method of  claim 59 , wherein the fibrotic disease is Crohn's disease. 
     
     
         100 . The method of  claim 59 , wherein the fibrotic disease is post-myocardial infarction induced fibrosis. 
     
     
         101 . The method of  claim 59 , wherein the fibrotic disease is inherited cardiomyopathy.