US2023372637A1PendingUtilityA1

Delivery system

Assignee: UNIV WAKE FOREST HEALTH SCIENCESPriority: Mar 7, 2011Filed: Aug 3, 2023Published: Nov 23, 2023
Est. expiryMar 7, 2031(~4.6 yrs left)· nominal 20-yr term from priority
A61M 11/00A61B 5/6835A61B 5/1077A61B 5/1079A61B 5/445A61B 5/0064A61L 27/225A61L 27/24A61L 27/3813A61L 27/60C12N 5/0656A61M 35/20B41J 3/4073A61F 2/02A61B 2017/00969A61B 2017/3225A61B 90/50A61B 34/30A61B 2034/105A61F 2/10
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Claims

Abstract

Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.

Claims

exact text as granted — not AI-modified
1 .- 61 . (canceled) 
     
     
         62 . A delivery system comprising:
 an optical detector comprising a three-dimensional scanner,   wherein the optical detector is configured to perform detection of data to create a map of an area of interest of a patient;   a depth detector operatively associated with the optical detector and configured to account for movement of the patient during the detection;   a dispenser operatively associated with the optical detector and configured to deliver cells and/or compositions to the area of interest based upon the data and/or the map;   a three-dimensional plotter operatively connected with the three-dimensional scanner; and   a controller operatively connected with the dispenser.   
     
     
         63 . The delivery system of  claim 62 , wherein the depth detector comprises an infrared detector and/or a laser scanner. 
     
     
         64 . The delivery system of  claim 63 , wherein the three-dimensional scanner is a hand-held laser scanner. 
     
     
         65 . The delivery system of  claim 62 , wherein the dispenser comprises a plurality of nozzles. 
     
     
         66 . The delivery system of  claim 65 , further comprising one or more cartridges loaded with the cells and/or compositions, wherein the nozzles are in fluid communication with the one or more cartridges. 
     
     
         67 . The delivery system of  claim 66 , wherein the nozzles are configured for pressure-based delivery of the cells and/or compositions. 
     
     
         68 . The delivery system of  claim 66 , wherein the cells and/or compositions comprise cells selected from the group consisting of cartilage cells, bone cells, muscle cells, vascular cells, skin cells, and combinations thereof 
     
     
         69 . The delivery system of  claim 62 , wherein the area of interest is a closed wound. 
     
     
         70 . The delivery system of  claim 62 , wherein the area of interest comprises an injury or disease of the patient. 
     
     
         71 . The delivery system of  claim 62 , further comprising a computing system comprising:
 a processor; and   a memory coupled to the processor and comprising computer readable program code that when executed by the processor causes the processor to perform operations comprising:   interpreting the data from the optical detector to form the map of the area of interest;   transforming the map into a negative mold of the area of interest, wherein the mold comprises a plurality of Z-axis layers; and   overlaying each of the Z-axis layers with a series of lines, wherein the lines provide a path for the dispenser to deliver the cells and/or compositions to the area of interest.   
     
     
         72 . The delivery system of  claim 62 , further comprising a surgical device that is configured to provide the optical detector and/or the dispenser with access to the area of interest. 
     
     
         73 . The delivery system of  claim 72 , wherein the surgical device is an endoscopic device.

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