Intranasal administration

Abstract

A nosepiece for delivering substance to a nasal cavity of a subject, the nosepiece comprising a body part which comprises a base portion which defines a flow passage therethrough, and a projection at a distal end of the base portion which at least in part provides a tip of the nosepiece and confers a rigidity in the sagittal direction, which enables the tip to open fleshy tissue at an upper region of the nasal valve and thereby expand an open area of the nasal valve, and a flexibility in a lateral direction, orthogonal to the sagittal plane, which facilitates insertion of the tip into the nasal valve.

1 - 42 . (canceled) 
     
     
         43 . A nosepiece for delivering substance to a nasal cavity of a subject, the nosepiece comprising an inner body part and an outer body part, the inner body part comprising a base portion, which defines a flow passage therethrough, and a projection extending from a distal end of the base portion, which at least in part supports the outer body part providing rigidity to the outer body part in a sagittal direction adjacent a tip of the nosepiece and flexibility to the outer body part in a lateral direction, orthogonal to the sagittal direction, adjacent the tip of the nosepiece; wherein the outer body part is configured to engage fleshy tissue at an upper region of a nasal valve of a subject and to thereby expand an open area of the nasal valve; wherein the projection extends axially in substantially parallel and offset relation to the longitudinal axis of the nosepiece and comprises a flat element with a length in the sagittal direction which is greater than a length in the lateral direction. 
     
     
         44 . The nosepiece of  claim 43 , wherein the outer body part is made from a material having less rigidity than the inner body part. 
     
     
         45 . The nosepiece of  claim 44 , wherein the outer body part is formed of a resilient material and encapsulates the inner body part. 
     
     
         46 . The nosepiece of  claim 43 , wherein the base portion defines a substantially annular surface at a distal end thereof, wherein the surface of the base portion is inclined from the projection in a proximal direction, wherein the base portion is shorter at a side thereof opposite to the projection. 
     
     
         47 . The nosepiece of  claim 43 , wherein the length of the projection in the sagittal direction is at least 1.5 times greater than a mean length of the projection in the lateral direction. 
     
     
         48 . The nosepiece of  claim 43 , wherein the length of the projection in the sagittal direction is at least 1.7 times greater than a mean length of the projection in the lateral direction. 
     
     
         49 . The nosepiece of  claim 43 , wherein the length of the projection in the sagittal direction is at least 1.9 times greater than a mean length of the projection in the lateral direction. 
     
     
         50 . The nosepiece of  claim 43 , wherein the length of the projection in the sagittal direction is at least 2 times greater than a mean length of the projection in the lateral direction. 
     
     
         51 . The nosepiece of  claim 43 , wherein the length of the projection in the sagittal direction is less than 3 mm. 
     
     
         52 . The nosepiece of  claim 43 , wherein the length of the projection in the sagittal direction is less than 2.5 mm. 
     
     
         53 . The nosepiece of  claim 43 , wherein the length of the projection in the sagittal direction is greater than 1.5 mm. 
     
     
         54 . The nosepiece of  claim 43 , wherein the length of the projection in the lateral direction is less than 1.5 mm. 
     
     
         55 . The nosepiece of  claim 43 , wherein the length of the projection in the lateral direction is less than 1.25 mm. 
     
     
         56 . The nosepiece of  claim 43 , wherein the length of the projection in the lateral direction is greater than 0.5 mm. 
     
     
         57 . The nosepiece of  claim 43 , wherein the length of the projection in the lateral direction is greater than 0.75 mm. 
     
     
         58 . The nosepiece of  claim 43 , wherein the projection has a main body section and a tip section which has a shorter length in the sagittal direction than a length of the main body section in the sagittal direction. 
     
     
         59 . The nosepiece of  claim 43 , wherein the projection defines a step at an inner edge thereof. 
     
     
         60 . The nosepiece of  claim 43 , wherein the projection has a tapering lateral cross-section along a longitudinal direction thereof, wherein the length of the projection in the lateral direction gets smaller toward the distal end of the projection. 
     
     
         61 . A nasal delivery device comprising the nosepiece of  claim 43 .