Device and methods for targeted tissue drug delivery

Abstract

Representative embodiments of the present invention provide for novel, minimally invasive implantable devices and methods for targeted tissue drug delivery of cardiovascular drugs.

That which is claimed is: 
     
         1 . A minimally invasive device for treatment of a patient, the device comprising:
 a. at least one inner catheter comprising an inner catheter conductor;   b. an outer catheter substantially surrounding the at least one inner catheter; and   c. at least one electrically conductive element located at a substantially distal portion of the device, wherein the at least one electrically conductive element is adapted to provide defibrillation energy to a cardiac surface of the patient.   
     
     
         2 . The device according to  claim 1 , wherein the device further comprises at least one drug delivery channel for delivery of at least one drug to the cardiac surface of the patient. 
     
     
         3 . The device according to  claim 1 , wherein the device comprises a plurality of electrically conductive elements. 
     
     
         4 . The device according to  claim 3 , wherein the plurality of electrically conductive elements are arranged in a flower-like arrangement fanning out from a central hub. 
     
     
         5 . The device according to  claim 3 , wherein at least one membrane substantially interconnects each of the plurality of electrically conductive elements. 
     
     
         6 . The device according to  claim 5 , wherein at least one adhesive material is provided on an underside of the membrane. 
     
     
         7 . The device according to  claim 6 , wherein the at least one adhesive material comprises at least one adhesive polymer. 
     
     
         8 . The device according to  claim 2 , wherein the at least one drug comprises at least one anti-arrhythmic drug. 
     
     
         9 . The device according to  claim 8 , wherein the at least one anti-arrhythmic drug is selected from the group consisting of procainamide, amiodarone, a combination of procainamide and at least one other anti-arrhythmic drug, a combination of amiodarone and at least one other anti-arrhythmic drug, and a combination of procainamide, amiodarone and at least one other anti-arrhythmic drug. 
     
     
         10 . The device according to  claim 2 , wherein the at least one drug further comprises at least one anesthetic drug. 
     
     
         11 . The device according to  claim 10 , wherein the anesthetic drug is selected from the group consisting of procaine, lidocaine, a combination of procaine and at least one other anesthetic drug, a combination of lidocaine and at least one other anesthetic drug, and a combination of procaine, lidocaine, and at least one other anesthetic drug. 
     
     
         12 . A minimally invasive device for treatment of a patient, the device comprising:
 a. at least one inner catheter comprising an inner catheter conductor and at least one drug delivery channel located within the inner catheter;   b. an outer catheter substantially surrounding the at least one inner catheter; and   c. at least one electrically conductive element located at a substantially distal portion of the device, wherein the distal portion of the device further comprises at least one drug release site for delivery of at least one drug to the cardiac surface of the patient.   
     
     
         13 . A minimally invasive device for treatment of a patient, the device comprising:
 a. at least one inner catheter;   b. at least one drug delivery channel located within the inner catheter; and   c. an outer catheter substantially surrounding the at least one inner catheter, wherein a substantially distal portion of the device further comprises at least one drug release site for delivery of at least one drug to the cardiac surface of the patient.   
     
     
         14 . The device of  claim 13 , further comprising at least one electrically conductive element located at the substantially distal portion of the device. 
     
     
         15 . A method of treating a patient suffering from an abnormal cardiac rhythm, the method comprising implanting a minimally invasive device, the device comprising:
 a. at least one inner catheter comprising an inner catheter conductor and at least one drug delivery channel located within the inner catheter;   b. an outer catheter substantially surrounding the at least one inner catheter; and   c. at least one electrically conductive element located at a substantially distal portion of the device, wherein the at least one electrically conductive element is adapted to provide defibrillation energy to a cardiac surface of the patient, wherein the distal portion of the device further comprises at least one drug release site for delivery of at least one drug to the cardiac surface of the patient.   
     
     
         16 . The method according to  claim 15 , wherein the device comprises a plurality of electrically conductive elements. 
     
     
         17 . The method according to  claim 16 , wherein the plurality of electrically conductive elements are arranged in a flower-like arrangement funning out from a central hub. 
     
     
         18 . The method according to  claim 16 , wherein at least one membrane substantially interconnects each of the plurality of electrically conductive elements. 
     
     
         19 . The method according to  claim 18 , wherein at least one adhesive material is provided on an underside of the membrane. 
     
     
         20 . The method according to  claim 19 , wherein the at least one adhesive material comprises at least one adhesive polymer. 
     
     
         21 . The method according to  claim 15 , wherein the at least one drug comprises at least one anti-arrhythmic drug. 
     
     
         22 . The method according to  claim 21 , wherein the at least one anti-arrhythmic drug is selected from the group consisting of procainamide, amiodarone, a combination of procainamide and at least one other anti-arrhythmic drug, a combination of amiodarone and at least one other anti-arrhythmic drug, and a combination of procainamide, amiodarone and at least one other anti-arrhythmic drug. 
     
     
         23 . The method according to  claim 15 , wherein the at least one drug further comprises at least one anesthetic drug. 
     
     
         24 . The method according to  claim 23 , wherein the anesthetic drug is selected from the group consisting of procaine, lidocaine, a combination of procaine and at least one other anesthetic drug, a combination of lidocaine and at least one other anesthetic drug, and a combination of procaine, lidocaine, and at least one other anesthetic drug.