Devices, systems, and methods for treatment of intracranial aneurysms

Abstract

Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.

I/We claim: 
     
         1 . A device for treating an aneurysm, the device comprising:
 a mesh having an expanded, unconstrained state, the mesh formed of a plurality of braided filaments, each of the filaments having a first end and a second end, wherein the mesh has a proximal portion configured to be positioned over the neck of an aneurysm and a distal portion;   a first coupler at the proximal portion, wherein the first ends are secured relative to one another at the first coupler; and   a second coupler at the distal portion, wherein the second ends are secured relative to one another at the second coupler,   wherein the mesh is formed of a wall comprising a first portion, a second portion, and a ridge, wherein the first portion extends between the first coupler and the ridge and the second portion extends between the ridge and the second coupler, and   wherein the mesh includes a cavity at the distal portion, and wherein all or a portion of the distal coupler is positioned within the cavity.   
     
     
         2 . The device of  claim 1 , wherein the mesh has a single layer delivery configuration. 
     
     
         3 . A method for imaging treatment of an aneurysm, the method comprising:
 acquiring a first image visualizing:   an occlusive member positioned within an aneurysm, the occlusive member including a first radiopaque marker; and   a conduit having a distal portion positioned within an aneurysm, the distal portion of the conduit including a second radiopaque marker; and   acquiring a second image in which the first radiopaque marker is further from the second radiopaque marker than in the first image.   
     
     
         4 . The method of  claim 3 , wherein, in the second image, the first radiopaque marker is positioned proximal to the second radiopaque marker and/or closer to a neck of the aneurysm than in the first image. 
     
     
         5 . The method of  claim 3 , wherein, in the first image, the first radiopaque marker is positioned in a distal half of the occlusive member, on a distal-facing surface of the occlusive member, and/or proximal to second radiopaque marker. 
     
     
         6 . The method of  claim 3 , wherein, in the first image and in the second image, the second radiopaque marker is disposed nearer to a dome of the aneurysm than the first radiopaque marker. 
     
     
         7 . The method of  claim 3 , wherein, in the second image, a radiopaque occlusive element is visible in a space between the first radiopaque marker and the second radiopaque marker. 
     
     
         8 . The method of  claim 3 , further comprising acquiring a third image in which the first radiopaque marker is further from the second radiopaque marker than in the second image. 
     
     
         9 . A method for making an occlusive device, the method comprising:
 obtaining a tubular mesh having a lumen therethrough;   obtaining a forming member having an outer surface and an inner surface;   everting the mesh over the forming member such that a first portion of the mesh conforms to the outer surface of the forming member and a second portion of the mesh conforms to the inner surface of the forming member;   setting a shape of the mesh while positioned over the forming member.   
     
     
         10 . The method of  claim 9 , wherein the inner surface of the forming member is arcuate and defines a cavity in the forming member. 
     
     
         11 . The method of Clause 1 or Clause 2, wherein the forming member has a substantially hemispherical shape. 
     
     
         12 . The method of  claim 9 , wherein the forming member includes a lumen extending therethrough. 
     
     
         13 . The method of  claim 9 , wherein the forming member is a first forming member, the inner surface is a first mating surface, and the method further comprises positioning the second portion of the mesh between the first mating surface of the first forming member and a second mating surface of a second forming member such that the second portion of the mesh conforms to the first and second mating surfaces of the first and second forming members, respectively. 
     
     
         14 . The method of  claim 13 , further comprising compressing the second portion of the mesh between the first and second mating surfaces. 
     
     
         15 . The method of  claim 9 , wherein setting the shape of the mesh comprises heat-treating the mesh while positioned on the forming member. 
     
     
         16 . The method of  claim 9 , wherein, after setting the shape of the mesh, the first and second portions of the mesh form a dual-layer sidewall that encloses an open volume. 
     
     
         17 . The method of  claim 16 , wherein the dual-layer sidewall has a generally hollow, hemispherical shape. 
     
     
         18 . The method of  claim 16  or  claim 17 , wherein the open volume has a substantially hemispherical shape. 
     
     
         19 . The method of  claim 18 , wherein the open volume is generally disc shaped. 
     
     
         20 . The method of  claim 9 , wherein, after setting the shape of the mesh, the mesh comprises a third portion that is generally tubular.