Metallo-liothyronine

Abstract

The invention relates to supramolecular metal coordinated liothyronine (triiodothyronine, T3) compositions, methods of preparing such compositions, methods of purifying and formulating supramolecular metal coordinated liothyronine, and methods of treating hypothyroidism and other disease states using such compositions.

What is claimed is: 
     
         1 . A supramolecular metal coordination complex according to formula I:
 [M x D o A p W q ] n , wherein:
 M is a metal atom; 
 D is a biologically active moiety that comprises at least two functional groups that are capable of coordinating to a divalent metal; 
 A is a second biologically active moiety or adjuvant; 
 W is H 2 O; 
 x is an integer from 1 to 10; 
 o is an integer from 1 to 10; 
 a p to x ratio is from about 1 to 1000 to about 1000 to 1; 
 q is zero or an integer from 1 to 20; and 
 n is an integer greater than or equal to 2.