Hemostatic compositions

Abstract

The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates to a method for preparing such composition, and to a unit comprising such composition and a spraying device.

1 . A hemostatic composition in powder form comprising:
 collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and   at least one monosaccharide.   
     
     
         2 . The composition of  claim 1 , wherein said composition comprises a collagen content ranging from 80% to 90% by weight relative to the total weight of the composition. 
     
     
         3 . The composition of  claim 1 , wherein said composition comprises a monosaccharide content ranging from 1% to 12.5% by weight relative to the total weight of the composition. 
     
     
         4 . The composition of  claim 1 , wherein said composition comprises a collagen/monosaccharide weight ratio ranging from 10 to 50. 
     
     
         5 . The composition of  claim 1 , wherein the collagen comprises a content of fibrous collagen and/or fibrillar collagen ranging from 85% to 95% by weight relative to the total weight of the collagen. 
     
     
         6 . The composition of  claim 1 , wherein said composition further comprises a glycosaminoglycan content ranging from 2% to 25% by weight relative to the total weight of the composition. 
     
     
         7 . The composition of  claim 1 , wherein said composition further comprises a collagen/total carbohydrate compounds weight ratio ranging from 2 to 40, wherein the weight of the total carbohydrate compounds is the sum of the weight of the monosaccharide(s) and the weight of the glycosaminoglycan(s). 
     
     
         8 . The composition of  claim 1 , wherein said composition further comprises coagulation factor in an amount ranging from 0.01 IU/mg to 20 IU/mg of the composition. 
     
     
         9 . The composition of  claim 1 , wherein said composition has a tapped density greater than 0.4 g/mL. 
     
     
         10 . The composition of  claim 1 , wherein said composition comprises at least 50% by weight of particles whose size is between 200 μm and 400 μm. 
     
     
         11 . The composition of  claim 1 , comprising:
 collagen of in an amount of 86.36% by weight relative to the total weight of the composition,   glucose, in an amount of 4.54% by weight relative to the total weight of the composition,   chondroitin sulfate, in an amount of 9.09% by weight relative to the total weight of the composition.   
     
     
         12 . The composition of  claim 11 , further comprising thrombin, in an amount of 0.2 IU/mg to 2 IU/mg of the composition. 
     
     
         13 . A method for preparing a hemostatic composition comprising at least the following steps:
 a) formation of an aqueous suspension comprising a collagen of fibrillar type having a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide,   b) recovery of the product in the form of precipitate, paste or gel, notably by centrifugation or decantation,   c) drying of the product,   d) grinding of the product to the desired granulometry.   
     
     
         14 . The method of  claim 13 , wherein the collagen used in step a) is obtained by basic extraction. 
     
     
         15 . The method of  claim 13 , further comprising a step e) subsequent to the step d), consisting in adding least one compound selected from:
 coagulation factors, notably thrombin, and   glycosaminoglycans, in particular chondroitin sulfate, dermatan sulfate, hyaluronic acid and mixtures thereof.   
     
     
         16 . A method of controlling hemostasis which comprises applying the  claim 1  for the use of same as a hemostatic agent to a patient in need thereof. 
     
     
         17 . A kit comprising:
 the composition of  claim 1 , and   a spraying device.   
     
     
         18 . The composition of  claim 4 , wherein the collagen/monosaccharide weight ratio is 19. 
     
     
         19 . The composition of  claim 8 , wherein the coagulation factor is thrombin.