Therapeutic agents and methods

Abstract

The invention provides glucocorticoid receptor antagonists for treatment of infection, neoplasia, and fatty liver disease.

What is claimed is: 
     
         1 . A composition for treating or preventing a disease or disorder in a plant, comprising an effective amount of at least one active agent, wherein the active agent is selected from the group consisting of: TPR-1, OR 1, MR 1, TCY1, PT150, PT155, PT156 PT157, PT158, PT159, PT160, PT162, PT163, PT164, PT165, PT166, PT167, combinations thereof, and agricultural acceptable salts thereof; and at least one agricultural acceptable excipient. 
     
     
         2 . The composition of  claim 1 , in a form suitable for application to a plant or plant locus. 
     
     
         3 . The composition of  claim 2 , wherein the composition is in a form selected from the group consisting of an emulsifiable concentrate, coatable paste, sprayable or dilutable solution, dilute emulsion, wettable powder, soluble powder, dust, granulate, encapsulation and aqueous solution. 
     
     
         4 . A kit for treating or preventing a disease or disorder in a plant, the kit comprising:
 a therapeutically effective amount of at least one active agent in a form suitable for application to a plant or plant locus, wherein the active agent is selected from the group consisting of: TPR-1, OR 1, MR 1, TCY1, PT150, PT155, PT156 PT157, PT158, PT159, PT160, PT162, PT163, PT164, PT165, PT166, and PT167;   a container containing the composition; and   instructions for using the composition.   
     
     
         5 . A method of preventing or treating a disease or disorder in a plant, the method comprising the steps of:
 selecting a plant in need of preventing or treating a disease or disorder; and   administering to the plant at least one agent selected from the group consisting of TPR-1, OR 1, MR 1, TCY1, PT150, PT155, PT156 PT157, PT158, PT159, PT160, PT162, PT163, PT164, PT165, PT166, and PT167, combinations thereof, and agricultural acceptable salts thereof.   
     
     
         6 . The method of  claim 5 , wherein the at least one agent is administered by at least one of spraying, atomizing, dusting, scattering, injectable, spray, a drench, a foliar, coating and pouring. 
     
     
         7 . The method of  claim 5 , wherein the disease or disorder is selected from the group consisting of viral infection, bacterial infection, microbial infection, fungal infection, parasitic infection, and combinations thereof. 
     
     
         8 . The method of  claim 5 , wherein the plant is a citrus plant and wherein the disease or disorder is selected from the group consisting of Huanglongbing (HLB), canker, bacterial spot, black pit, blast and citrus variegated chlorosis and citrus tristeza. 
     
     
         9 . The method of  claim 5 , wherein the disease or disorder is caused by an infection with at least one member of the group consisting of  Xanthomonas campestris, Xanthomonas axonopodis, Xanthomonas campestris  pv.,  Pseudomonas syringae, Xylella fastidiosa, Candidatus Liberibacter asiaticus, Erwinia amylovora, Agrobacterium tumefaciens, Agrobacterium rhizogenes, Ralstonia solanacearum, Clavibacter michiganesis, Xanthomonas campestris vesicatoria, Erwinia carotovora, Ralstonia solanacearu, Pseudomonas corrugate, Pseudomonas amygdale, Xanthomonas axonopodis  pv.,  Glycines, Ralstonia solanacearum, Curtobacterium flaccumfaciens, Xanthomonas species, Erwinia species, Erwinia chrysanthemi, Erwinia ananas, Erwinia herbicola, Erwinia carotovora , and Acetic acid bacteria. 
     
     
         10 . The method of  claim 6  wherein the disease or disorder is a fungal infection caused by infection with at least one member selected from the group consisting of  Pythium  spp.,  Fusarium  spp.,  Rhizoctonia  spp.,  Cercospora  spp.,  Alternaria  spp.,  Colletotrichum  spp.,  Ustilago  spp.,  Phoma  spp.,  Gibberella  spp.  Penicillium  spp.,  Glomerella  spp.  Diplodia  spp.,  Curvularia  spp.,  Sclerospora  spp.,  Peronosclerospora  spp.,  Puccinia  spp.,  Aspergillus  spp.,  Phomopsis  spp.,  Diaporthe  spp.,  Botrytis  spp.,  Verticillium  spp.,  Phytophthors  spp.,  Sclerophthora  spp.,  Erysipthe  spp.,  Sclerotinia  spp.,  Pyricularia  spp.,  Typhula  spp.,  Microdochium  spp.,  Helminthosporium  spp.,  Gaeumannomyces  spp.,  Ophiospaerella  spp.,  Magnaporthe  spp.,  Thielaviopsis  spp.,  Verticillium  spp.,  Magnaporthe  spp,  Rhizoctonia  spp.,  Phakospora  spp.,  Puccinia  spp.,  Pythium  spp., and  Phytophthora  spp. 
     
     
         11 . The method of  claim 5 , where the disease or disorder is a pest condition. 
     
     
         12 . The method of  claim 11 , wherein the pest condition is selected from the group consisting of a plant pest, plant pathogen and crop pest. 
     
     
         13 . The method of  claim 12 , wherein the crop pest is caused by a member selected from the group consisting of Psyllidae, psyllids toaphids, caterpillars, flies, wasps, nematodes, mites, gastropods, Phytoplasma, Spiroplasma, protozoa, piercing-sucking insects, phloem-inhabiting prokaryotic pathogens, and plant eating insects.