US2023398113A1PendingUtilityA1

Compositions and methods for the treatment of presbyopia

78
Assignee: LENZ THERAPEUTICS INCPriority: Dec 16, 2021Filed: Aug 28, 2023Published: Dec 14, 2023
Est. expiryDec 16, 2041(~15.4 yrs left)· nominal 20-yr term from priority
Inventors:Gerald Horn
A61K 31/498A61K 31/439A61P 27/10A61K 47/02A61K 47/10A61K 47/40A61K 47/36A61K 9/0048A61K 47/26A61K 47/38A61K 47/12A61K 47/183
78
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Claims

Abstract

The present invention is directed to compositions for and methods for the treatment of presbyopia comprising from about 0.3% to about 2.0% w/v aceclidine and from about 0.07% to about 0.15% w/v brimonidine.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of treating presbyopia comprising administering a composition comprising from about 1% to about 2% w/v aceclidine or a salt thereof and from 0.07% to about 0.15% brimonidine or a salt thereof to a subject in need thereof. 
     
     
         2 . The method of  claim 1 , wherein said aceclidine is at a concentration from about 1.5% to about 2% w/v. 
     
     
         3 . The method of  claim 1 , wherein said brimonidine is at a concentration from 0.07% to about 0.09% w/v. 
     
     
         4 . The method of  claim 3 , wherein said aceclidine is at a concentration from about 1.5% to about 2% w/v. 
     
     
         5 . The method of  claim 1 , wherein said brimonidine is at a concentration of 0.08% w/v. 
     
     
         6 . The method of  claim 1 , wherein a pH of said composition is between about 4.5 and about 6.5. 
     
     
         7 . The method of  claim 1 , wherein a pH of said composition is between about 5.0 and about 5.75. 
     
     
         8 . The method of  claim 2 , wherein a pH of said composition is between about 4.5 and about 6.5. 
     
     
         9 . The method of  claim 3 , wherein a pH of said composition is between about 4.5 and about 6.5. 
     
     
         10 . The method of  claim 4 , wherein a pH of said composition is between about 4.5 and about 6.5. 
     
     
         11 . The method of  claim 1 , wherein said subject experiences no rebound redness. 
     
     
         12 . The method of  claim 1 , wherein said subject experiences no tachyphylaxis. 
     
     
         13 . The method of  claim 1 , wherein said subject experiences an effect of said treatment of presbyopia for a duration of at least 4 hours. 
     
     
         14 . A method of treating presbyopia comprising administering a composition comprising about 1.75% aceclidine or a salt thereof and about 0.08% w/v brimonidine or a salt thereof to a subject in need thereof. 
     
     
         15 . The method of  claim 14 , wherein said composition has a pH of about 4.5 to about 6.5. 
     
     
         16 . The method of  claim 14 , wherein said subject experiences no tachyphylaxis. 
     
     
         17 . The method of  claim 14 , wherein said subject experiences an effect of said treatment of presbyopia for a duration of at least 4 hours.

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