Peptide compositions and methods for ameliorating skin laxity and body contour

Abstract

Compositions and methods for amelioration of skin laxity and body contour are provided. Provided herein are compositions comprising a combination of peptides.

What is claimed is: 
     
         1 . A topical composition comprising:
 a tripeptide-1;   a hexapeptide-11; and   a hexapeptide-12.   
     
     
         2 . The topical composition of  claim 1 , wherein the composition, when applied to skin, is effective to achieve at least one selected from: reduced skin laxity; improved skin texture; decreased skin crepiness; improved body contouring; accelerated fat reduction; and elimination of lipid droplets. 
     
     
         3 . The topical composition of  claim 1 , wherein the tripeptide-1 is present at a concentration of about 1 ppm to about 1000 ppm. 
     
     
         4 . The topical composition of  claim 1 , wherein the tripeptide-1 is present at a concentration of about 1 ppm to about 50 ppm. 
     
     
         5 . The topical composition of  claim 1 , wherein the tripeptide-1 is present at a concentration of about 1 ppm to about 10 ppm. 
     
     
         6 . The topical composition of  claim 1 , wherein the hexapeptide-11 is present at a concentration of about 0.001 wt. % to about 6 wt. %, relative to the total weight of the composition. 
     
     
         7 . The topical composition of  claim 1 , wherein the hexapeptide-12 is present at a concentration of about 0.5 ppm to about 1000 ppm. 
     
     
         8 . The topical composition of  claim 1 , wherein the hexapeptide-12 is present at a concentration of about 0.5 ppm to about 10 ppm. 
     
     
         9 . The topical composition of  claim 1 , further comprising a tetrapeptide-2. 
     
     
         10 . The composition of  claim 1 , wherein at least one of the tripeptide-1, the hexapeptide-11, and the hexapeptide-12 are functionalized with a fatty acid selected from the group consisting of: myristoleic acid; palmitoleic acid; sapienic acid; oleic acid; elaidic acid; vaccenic acid; linoleic acid; linoelaidic acid; α-linolenic acid; arachidonic acid; eicosapentaenoic acid; erucic acid; docosahexaenoic acid; caprylic acid; capric acid; lauric acid; palmitic acid; stearic acid; arachidic acid; behenic acid; lignoceric acid; and cerotic acid. 
     
     
         11 . The composition of  claim 1 , wherein the tripeptide-1 comprises palmitoyl tripeptide-1, myristoyl tripeptide-1, or a combination thereof. 
     
     
         12 . The composition of  claim 1 , wherein the hexapeptide-12 comprises one of palmitoyl hexapeptide-12, myristoyl hexapeptide-12, or a combination thereof. 
     
     
         13 . The topical composition of  claim 1 , further comprising at least one selected from the group consisting of: hydrolyzed  Candida saitoana  extract;  Plantago lanceolata  extract;  Euglena gracilis  extract;  Glaucium flavum  extract; hydroxymethoxyphenyl decanone;  Tremella fuciformis  extract; ceramide; palmitic acid; shea butter; bentonite; phytoene/phytofluene; caffeine; niacinamide; lecithin; avocado extract; dill extract; flax seed/linseed extract; oleuropein;  Centella asiatica  extract; and phosphatidylserine. 
     
     
         14 . The topical composition of  claim 1 , wherein:
 the tripeptide-1 is present at a concentration of about 0.0001 wt. % to about 10 wt. %, relative to the weight of the total composition;   the hexapeptide-11 is present at a concentration of about 0.001 wt. % to about 6 wt. %, relative to the total weight of the composition; and   the hexapeptide-12 is present at a concentration of about 0.00005 wt. % to about 10 wt. %, relative to the total weight of the composition.   
     
     
         15 . The composition of  claim 2 , wherein the composition is applied to skin before or after a body shaping or body contouring procedure comprising at least one of: low-level laser therapy; infrared light therapy; pulsed focused ultrasound therapy; radiofrequency induced electroporation; injection of lipolytic agents; liposuction; cryolipolysis; and surgical body contouring. 
     
     
         16 . The composition of  claim 2 , wherein the composition is applied to skin of the submental region, abdomen, face, flank, back, neck, arm, leg, buttock, or combination thereof. 
     
     
         17 . A topical composition comprising:
 a tripeptide-1, present at a concentration of about 1 ppm to about 1000 ppm;   a hexapeptide-12, present at a concentration of about 0.5 ppm to about 1000 ppm;   a tetrapeptide-2; and   a hexapeptide-11.   
     
     
         18 . The topical composition of  claim 17 , wherein:
 the tripeptide-1 is present at a concentration of about 1 ppm to about 100 ppm; and   hexapeptide-12 is present at a concentration of about 0.5 ppm to about 10 ppm.   
     
     
         19 . The topical composition of  claim 16 , further comprising at least one of: niacinamide; lecithin; avocado extract; dill extract; oleuropein;  Centella asiatica  extract; and phosphatidylserine. 
     
     
         20 . The topical composition of  claim 16 , wherein the composition is applied to skin before or after a surgical procedure. 
     
     
         21 . The topical composition of  claim 17 , wherein the composition, when applied to skin, is effective to achieve at least one of: reduced skin laxity; improved skin texture; decreased skin crepiness; improved body contouring; accelerated fat reduction; and elimination of lipid droplets.