Terpene-based compositions, methods of preparations and uses thereof

Abstract

The present disclosure generally relates to terpene-based compositions for applications in the pharmaceutical and recreational fields. In some embodiments, the compositions are enriched compositions or non-naturally occurring compositions which contain defined concentrations of one or more cannabis -derived chemical compounds, such as terpenes and cannabinoids that have a distinctive characteristic that mimics that of a cannabis plant matter or a product thereof. Also provided in some embodiments of the disclosure are methods for the preparation of the compositions, as well as methods for use thereof.

1 . A method of making a composition for imparting one or more desired effects to a subject, the method comprising preparing a composition in which a plurality of chemical compounds which are known to occur in a  cannabis  strain and are associated with at least one desired effect in a subject are enriched, wherein the amounts or levels of said plurality of chemical compounds with respect to one another in said composition are about the amounts or levels of said plurality of chemical compounds with respect to one another in said  cannabis  strain. 
     
     
         2 . The method of  claim 1 , wherein said preparation of said composition comprises:
 obtaining a first enriched or purified composition of a first chemical compound from among said plurality of chemical compounds associated with at least one desired effect in a subject and which is known to occur in a  cannabis  strain, and   combining said first enriched or purified composition with a second enriched or purified composition of a second chemical compound from among said plurality of chemical compounds associated with at least one desired effect in a subject and which is known to occur in said  cannabis  strain.   
     
     
         3 . The method of  claim 1 , wherein the plurality of chemical compounds are selected from the group consisting of terpenes, terpenoids, cannabinoids, nitrogenous compounds, amino acids, proteins, glycoproteins, enzymes, sugars and related compounds, hydrocarbons, simple alcohols, aldehydes, ketones, simple acids, fatty acids, simple esters, lactones, steroids, non-cannabinoid phenols, flavonoids, vitamins, pigments, and other elements. 
     
     
         4 . The method of  claim 1 , wherein the plurality of chemical compounds comprises at least one terpene compound selected from the group consisting of monoterpenes, diterpenes, triterpenes, hemiterpenes, sesquiterpenes, sesterterpenes, sesquarterpenes, and notisoprenoids. 
     
     
         5 . The method of  claim 1 , wherein the plurality of chemical compounds comprises at least one terpene compound selected from the group consisting of 3-carene, α-bisabolol, β-caryophyllene, bisabolol, borneol, camphene, carene, caryophyllene, caryophyllene oxide, citronellol, eucalyptol, fenchol, geraniol, γ-terpinene, guaiol, humulene, isopulegol, limonene, linalool, menthol, myrcene, ocimene, p-cymene, phellandrene, phytol, α-pinene, β-pinene, terpenolene, terpinene, terpineol, and valencene. 
     
     
         6 . The method of  claim 1 , wherein the plurality of chemical compounds comprises at least one terpene compound selected from the group consisting of caryophyllene, limonene, linalool, myrcene, α-pinene, and β-pinene. 
     
     
         7 - 9 . (canceled) 
     
     
         10 . The method of  claim 1 , wherein said composition further comprises an essential oil. 
     
     
         11 - 13 . (canceled) 
     
     
         14 . The method of  claim 1 , wherein said plurality of chemical compounds comprises one or more cannabinoid compound. 
     
     
         15 . The method of  claim 14 , wherein the one or more cannabinoid compound is selected from the group consisting of cannabinol (CBN), cannabinolic acid (CBNA), Δ(9)-tetrahydrocannabinol (Δ(9)-THC), Δ(9)-tetrahydrocannabinolic acid (Δ(9)-THCA), Δ(9)-cannabidiol (Δ(9)-CBD), Δ(9)-cannabidiolic acid (Δ(9)-CBDA), Δ(8)-tetrahydrocannabinol (Δ(8)-THC), Δ(8)-tetrahydrocannabinolic acid (Δ(8)-THCA), Δ(8)-cannabidiol (Δ(8)-CBD), Δ(8)-cannabidiolic acid (Δ(8)-CBDA), Δ(9)-tetrahydrocannabivarin (Δ(9)-THV), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabichromene (CBC), cannabichromenic acid (CBCA), cannabicyclol (CBL), cannabicyclolic acid (CBLA), active analogues and derivatives of any one thereof. 
     
     
         16 . (canceled) 
     
     
         17 . (canceled) 
     
     
         18 . The method of  claim 1 , wherein the composition further comprises a medium-chain fatty acid triester of glycerol (medium-chain triglyceride—MCT). 
     
     
         19 . The method of  claim 18 , wherein the MCT comprises at least one medium-chain fatty acid having an aliphatic tail of 6-12 carbon atoms. 
     
     
         20 . The method of  claim 19 , wherein the at least one medium-chain fatty acid is selected from the group consisting of caproic acid (hexanoic acid), caprylic acid (ocanoic acid), capric acid (decanoic acid), and lauric acid (dodecanoic acid). 
     
     
         21 . The method of  claim 18 , wherein the medium-chain fatty acid comprises caprylic acid. 
     
     
         22 . The method of  claim 18 , wherein the ratio of the MCT amount to the amount of the at least one terpene compound is from about 1:1000 to about 1000:1 by volume. 
     
     
         23 . The method of  claim 18 , wherein the ratio of the MCT amount to the amount of the at least one terpene compound is from about 100:1 to about 3:1 by volume. 
     
     
         24 - 27 . (canceled) 
     
     
         28 . A method for characterizing a  cannabis  strain, the method comprising identifying one or more genetic characteristics present in a biological sample from said  cannabis  strain wherein said one or more genetic characteristics are associated with a desired level or amount of one or more chemical compounds in said  cannabis  strain which is associated with at least one desired effect in a subject. 
     
     
         29 - 64 . (canceled) 
     
     
         65 . A non-naturally occurring composition for conferring a desired effect to a subject, said composition comprising one or more  cannabis  terpene and a medium-chain triglyceride (MCT). 
     
     
         66 - 85 . (canceled) 
     
     
         86 . The composition of  claim 65 , wherein the desired effect is selected from the list consisting of reduced anxiety, reduced depression, improved alertness, cognitive ability enhancement, mood improvement, improved sleep quality, nausea reduction, pain relief, spasm relief, seizure decrease, muscle relaxation, antimicrobial, anti-diabetes, blood circulation improvement, psoriasis relief, anti-inflammation, relief of connective tissue disorder, bone stimulation, relief of rheumatoid arthritis, anti-oxidation, improvement to mobility (e.g., arthritis, multiple sclerosis), improvements to skin conditions (e.g., blemishes, scars, insect bites, hives, pimples), reduced seizures (epilepsy), reduction in hypertension, improved memory loss (e.g., dementia, Alzheimer's), reduced dependency on drugs (e.g. opioids, nicotine, alcohol), inhibition of cancer growth, increased metabolism, improvements to autoimmune disorders, appetite stimulation, reduced concussive injuries, and enhancement of skin penetration for transdermal delivery of therapeutic drugs. 
     
     
         87 . The composition of  claim 65 , wherein said composition is further formulated for administration orally, transdermally, topically, or parenterally. 
     
     
         88 . The composition of  claim 65 , wherein said composition is further formulated into a form selected from a tablet, a vaporizer inhalant, a capsule, a gel, a powder, an oral spray, a chewable gum, a sublingual film or lozenge, and a transdermal patch.