Compositions, devices and kits for selective internal radiation therapy

Abstract

Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.

What is claimed is: 
     
         1 . A method of preparing a therapy, comprising:
 determining an average tumor size of a tumor lesion;   selecting a  90 Y syringe activity level using the average tumor size; and   loading a dual chamber syringe with the selected  90 Y syringe activity level, wherein the dual chamber syringe comprises a first chamber pre-loaded with bovine serum albumin and a second chamber pre-loaded with glutaraldehyde, wherein loading the dual chamber syringe comprises loading the  90 Y syringe activity level into the first and second chambers of the dual chamber syringe in a 4:1 ratio.