Combination of tonic and burst stimulations to treat neurological disorders

Abstract

The present application relates to a new stimulation design which can be utilized to treat neurological conditions. The stimulation system produces a combination of burst and tonic stimulation which alters the neuronal activity of the predetermined site, thereby treating the neurological condition or disorder.

1 . A method of treating chronic pain in a patient with reduced paresthesia with an implantable pulse generator configured to operate according to burst stimulation parameters that define stimulation pulses to be repeated in bursts, wherein the burst stimulation parameters include a pulse repetition frequency of at least 200 Hz, a burst rate of at least 18 Hz, and a pulse width of approximately 1 ms, the method comprising:
 generating, by the implantable pulse generator, burst stimulation according to the stimulation parameters, wherein the burst stimulation includes a plurality of bursts with each burst including a plurality of pulses having the pulse width repeating at the pulse repetition frequency followed by quiescent periods such that bursts within the plurality of bursts repeat at the burst rate;   providing the burst stimulation from the implantable pulse generator to a stimulation lead; and   applying the burst stimulation to nerve tissue of the patient via one or more electrodes of the stimulation lead, wherein the burst stimulation causes the patient to experience pain relief with reduced paresthesia.   
     
     
         2 . The method of  claim 1 , wherein the applying applies the burst stimulation to the spinal cord of the patient. 
     
     
         3 . The method of  claim 1 , wherein the applying applies the burst stimulation to a dorsal root ganglion of the patient. 
     
     
         4 . The method of  claim 1 , wherein each burst of the plurality of bursts includes at least five (5) pulses. 
     
     
         5 . The method of  claim 1 , further comprising generating, by the implantable pulse generator, a tonic stimulation pulse to be repeated as tonic stimulation. 
     
     
         6 . The method of  claim 5  further comprising:
 programming the implantable pulse generator with one or more tonic stimulation parameters that define at least one stimulation pulse, of the tonic stimulation, to be repeated in a tonic manner; and 
 generating, by the implantable pulse generator, a combination of the burst stimulation and tonic stimulation according to the tonic and burst stimulation parameters. 
 
     
     
         7 . The method of  claim 6 , wherein the tonic and burst parameters are stimulation program parameters that are repeated in stimulation cycles by the implantable pulse generator. 
     
     
         8 . The method of  claim 5 , wherein the burst and tonic stimulation are applied to nerve tissue of the patient using different electrode combinations. 
     
     
         9 . The method of  claim 5 , wherein the generating generates a respective pulse for the tonic stimulation immediately before beginning pulses for an individual burst of the burst stimulation. 
     
     
         10 . The method of  claim 5 , wherein pulses for the tonic stimulation are generated between an occurrence of a first pulse of a respective burst and a last burst of the respective burst of the burst stimulation. 
     
     
         11 . The method of  claim 1 , wherein the burst stimulation is configured to treat, in addition to pain relief, at least one of a movement disorder, a sensory disorder, or tinnitus.