Use of pyronaridine, tilorone, and quinacrine against marburg virus and other virus infections

Abstract

Methods of treating or preventing diseases caused by viral infections via the administration of pyronaridine, quinacrine, and/or tilorone are described. The viral infections can be caused by viruses such as Marburg virus (MARV), Chikungunya virus (CHIKV), norovirus, Middle East Respiratory Syndrome coronavirus (MERS-CoV), and Nipah virus.

1 . A method of treating or preventing a disease caused by a Marburg virus (MARV) infection in a subject in need of treatment thereof, wherein the method comprises administering to the subject an effective amount of tilorone and/or a pharmaceutically acceptable salt thereof. 
     
     
         2 - 8 . (canceled) 
     
     
         9 . The method of  claim 1 , wherein the subject is a mammal. 
     
     
         10 . The method of  claim 9 , wherein the subject is a human. 
     
     
         11 . The method of  claim 1 , wherein the administering is performed via oral administration, intranasal administration, or intravenous administration. 
     
     
         12 - 19 . (canceled) 
     
     
         20 . The method of  claim 1 , wherein the MARV infection is an infection of MARV, strain Musoke. 
     
     
         21 . The method of  claim 1 , wherein the MARV infection is an infection of MARV, strain Angola.