Electronic apparatus for delivering coherent sine burst irreversible electroporation energy to a biological tissue

Abstract

Electronic apparatus (100) for delivering Coherent Sine Burst Irreversible Electroporation energy to a biological tissue (1) comprises at least one electrode (3) positionable on or near the biological tissue (1), a power generator (2) for supplying electric energy to the electrode (3), and to generate a respective electric signal (S) to energize the electrode (3). The electric signal (S) is formed by alternating over time a first electric signal (S1) with a second electric signal (S2), with each first electric signal (S1) being the same. The first electric signal (S1) is supplied to electrode (3) during a first time interval (T1) and the second electric signal (S2) is supplied to electrode (3) during a second time interval (T2), subsequent to the first time interval (T1). The first electric signal (S1) is a continuous bipolar signal which comprises two or more basic sine waves (SB) in the first time interval (T1).

1 . Electronic apparatus ( 100 ) for delivering Coherent Sine Burst Irreversible Electroporation energy to a biological tissue ( 1 ) to be treated, the electronic apparatus comprising:
 at least one electrode ( 3 ) positionable either on or near the biological tissue ( 1 ) to be treated; and   a power generator ( 2 ) for supplying electric energy to the or each electrode ( 3 ), said power generator ( 2 ) being configured to generate a respective electric signal (S) to energize the or each individual electrode ( 3 ),   wherein   the or each electric signal (S) is formed by alternating over time a first electric signal (S 1 ) with a second electric signal (S 2 ), each first electric signal (S 1 ) being the same;   said first electric signal (S 1 ) is supplied to an individual electrode ( 3 ) during a first time interval (T 1 ) and said second electric signal (S 2 ) is supplied to the individual electrode ( 3 ) during a second time interval (T 2 ) subsequent to the first time interval (T 1 );   said first electric signal (S 1 ) is a continuous bipolar signal comprising two or more basic sine waves (SB) in said first time interval (T 1 ), each basic sine wave having a peak-to-peak mean amplitude in the range 2,000 V to 20,000 V and consisting of one positive half-wave and one negative half-wave, each half-wave having the same width, and the first electric signal (S 1 ) having a frequency in the range 25 kHz to 75 kHz; and   said second electric signal (S 2 ) has an amplitude equal to zero in said second time interval (T 2 ).   
     
     
         2 .- 14 . (canceled)