Biophotonic compositions and methods for providing biophotonic treatment

Abstract

The present disclosure provides biophotonic topical compositions and methods useful in phototherapy. In particular, the biophotonic topical compositions of the present disclosure are substantially resistant to leaching such that very low amounts of chromophore(s) present in the biophotonic composition leach out of the composition. The biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.

1 .- 26 . (canceled) 
     
     
         27 . A biophotonic composition comprising:
 a first chromophore; and   a gelling agent present in an amount sufficient to gel the composition and render the biophotonic composition substantially resistant to leaching such that less than 15% by weight of the total chromophore amount leaches out of the biophotonic composition in use.   
     
     
         28 . The biophotonic composition of  claim 27 , wherein the substantial resistance to leaching comprises less than 15% of the total chromophore amount leaching out of the biophotonic composition into a phosphate saline buffer solution contained in a receptor compartment, through a 2.4-3 cm diameter polycarbonate (PC) membrane with a thickness of 10 microns and a pore size of 3 microns, having a top side onto which a 2 mm thick layer of the biophotonic composition is placed for 5 minutes at room temperature and pressure, and a bottom side which is in direct contact with the phosphate saline buffer solution. 
     
     
         29 . The biophotonic composition of  claim 27 , wherein the biophotonic composition is translucent. 
     
     
         30 . The biophotonic composition of  claim 29 , wherein the translucency comprises at least 20%, 30%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 85%, 90%, 95% or 100% transmittance of light through a 2 mm thick composition. 
     
     
         31 . The biophotonic composition of  claim 27 , wherein the gelling agent is a synthetic polymer selected from the group consisting of vinyl polymers, polyoxyethylene-polyoxypropylene copolymers, poly(ethylene oxide), acrylamide polymers and derivatives or salts thereof. 
     
     
         32 . The biophotonic composition of  claim 27 , further comprising a humectant. 
     
     
         33 . The biophotonic composition of  claim 32 , wherein the humectant is glycerine. 
     
     
         34 . The biophotonic composition of  claim 27 , further comprising an oxygen-releasing agent. 
     
     
         35 . The biophotonic composition of  claim 34 , wherein the oxygen-releasing agent is selected from the group consisting of hydrogen peroxide, carbamide peroxide, benzoyl peroxide, peroxy acid, alkali metal peroxides, alkali metal percarbonates, peroxyacetic acid, and alkali metal perborates. 
     
     
         36 . The biophotonic composition of  claim 27 , wherein the first chromophore is selected from the group consisting of Eosin Y, Eosin B, Erythrosin B, Fluorescein, Rose Bengal and Phloxin B. 
     
     
         37 . The biophotonic composition of  claim 27 , wherein the first chromophore is present in an amount of about 0.001% to about 40% by weight of the total composition, preferably about 0.005% to about 2% by weight of the total composition. 
     
     
         38 . The biophotonic composition of  claim 27 , wherein the biophotonic composition further comprises a second chromophore. 
     
     
         39 . The biophotonic composition of  claim 27 , wherein the first chromophore has an emission spectrum that overlaps at least 20% with an absorption spectrum of the second chromophore. 
     
     
         40 . The biophotonic composition of  claim 27 , wherein the first chromophore is Eosin Y, and the second chromophore is one or more of Fluorescein, Phloxine B and Erythrosine B. 
     
     
         41 . The biophotonic composition of  claim 27 , wherein the first chromophore is Fluorescein, and the second chromophore is Eosin Y. 
     
     
         42 . A biophotonic composition, comprising a first chromophore in a carrier medium, wherein the biophotonic composition is encapsulated in a membrane which membrane limits leaching of the first chromophore such that less than 15% of the total chromophore amount leaches out of the biophotonic composition in use. 
     
     
         43 . The biophotonic composition of claim  49 , wherein the membrane is translucent. 
     
     
         44 . The biophotonic composition of  claim 42 , wherein the membrane is selected from the group consisting of a lipid, a polymer, gelatin, cellulose, and cyclodextrins. 
     
     
         45 . The biophotonic composition of  claim 42 , wherein the composition further comprises a dendrimer. 
     
     
         46 . A method for providing cosmetic treatment, comprising:
 applying topically the biophotonic composition according to  claim 27  to a skin; and   illuminating said biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.