Magnesium-Based Porous Coating for Orthopedic Implant

Abstract

The present disclosure relates to an orthopedic implant. The orthopedic implant includes an elongated member having a first end and a second end opposite the first end. The orthopedic implant also includes a porous coating secured to an exterior surface of the elongated member. The porous coating includes magnesium phosphate.

1 . An orthopedic implant, comprising:
 an elongated member having a first end and a second end opposite the first end; and   a porous coating secured to an exterior surface of the elongated member, wherein the porous coating includes magnesium phosphate.   
     
     
         2 . The orthopedic implant of  claim 1 , wherein the porous coating further includes KH 2 PO 4  in an amount between about 20-70 dry weight percent, MgO in an amount between 10-50 dry weight percent, a calcium containing compound, and a poly-lactic acid. 
     
     
         3 . The orthopedic implant of  claim 2 , wherein the poly-lactic acid comprises one of Poly(L-lactic acid) PLA, poly(L, DL-lactide) PLDLA, and poly(L-lactide-co-glycolide) PLGA. 
     
     
         4 . The orthopedic implant of  claim 2 , wherein the porous coating further includes a bioactive therapeutic agent. 
     
     
         5 . The orthopedic implant of  claim 4 , wherein the bioactive therapeutic agent comprises one of amikacin, butirosin, dideoxykanamycin, fortimycin, gentamycin, kanamycin, lividomycin, neomycin, netilmicin, ribostamycin, sagamycin, seldomycin and epimers thereof, sisomycin, sorbistin, spectinomycin and tobramycin. 
     
     
         6 . The orthopedic implant of  claim 2 , wherein the porous coating further comprises a sugar, and wherein the sugar comprises one of sugar alcohols, sugar acids, amino sugars, sugar polymers glycosaminoglycans, glycolipds, sugar substitutes and combinations thereof. 
     
     
         7 . The orthopedic implant of  claim 1 , wherein a thickness of the porous coating on the exterior surface of the elongated member ranges from 200 μm to 50 mm. 
     
     
         8 . The orthopedic implant of  claim 1 , wherein the elongated member comprises titanium, polyetheretherketone (PEEK), polyurethane, bone, or a cured osteostimulative material. 
     
     
         9 . The orthopedic implant of  claim 1 , wherein the elongated member is tapered at the second end such that a width of the second end is less than a width of the first end. 
     
     
         10 . The orthopedic implant of  claim 9 , further comprising:
 a first channel positioned on a first side of the elongated member and extending from the first end to the second end;   a second channel positioned on a second side of the elongated member and extending from the first end to the second end; and   one or more through holes connecting the first channel to the second channel.   
     
     
         11 . The orthopedic implant of  claim 10 ,
 wherein the one or more through holes comprises a plurality of through holes.   
     
     
         12 . The orthopedic implant of  claim 10 , wherein the first channel is recessed in the first side of the elongated member, and wherein the second channel is recessed in the second side of the elongated member. 
     
     
         13 . The orthopedic implant of  claim 1 , wherein the porous coating comprises a powder with a particle size between 10 μm and 200 μm. 
     
     
         14 . The orthopedic implant of  claim 1 , wherein the porous coating is formed of sintered layers of powder that create a three-dimensional porous coating. 
     
     
         15 . The orthopedic implant of  claim 1 , wherein the porous coating is formed via a chemical vapor deposition process. 
     
     
         16 . A method for securing an orthopedic implant to a bone, the method comprising:
 providing the orthopedic implant of  claim 1 ;   removing a portion of the bone to create a cavity; and   inserting the second end of the elongated member of the orthopedic implant into the cavity in the bone.   
     
     
         17 . The method of  claim 16 , further comprising:
 applying an uncured osteostimulative material to an exterior surface of the elongated member.   
     
     
         18 . The method of  claim 16 , further comprising:
 inserting a ligament in the cavity in the bone; and   inserting the second end of the elongated member of the orthopedic implant into the cavity in the bone such that the elongated member fills a substantial portion of the cavity, wherein the ligament is securely fixed between the elongated member and an inner surface of the cavity in the bone.