Silk coated synthetic fabrics

Abstract

The disclosure provides novel silk fibroin coated articles and methods of preparing same.

1 . An article comprising a fabric and a coating, wherein the coating comprises a surfactant and/or emulsifier system, and silk fibroin fragments having an average weight average molecular weight selected from between about 1 kDa and about 5 kDa, from between about 5 kDa and about 10 kDa, from between about 6 kDa and about 17 kDa, from between about 10 kDa and about 15 kDa, from between about 14 kDa and about 30 kDa, from between about 15 kDa and about 20 kDa, from between about 17 kDa and about 39 kDa, from between about 20 kDa and about 25 kDa, from between about 25 kDa and about 30 kDa, from between about 30 kDa and about 35 kDa, from between about 35 kDa and about 40 kDa, from between about 39 kDa and about 54 kDa, from between about 39 kDa and about 80 kDa, from between about 40 kDa and about 45 kDa, from between about 45 kDa and about 50 kDa, from between about 50 kDa and about 55 kDa, from between about 55 kDa and about 60 kDa, from between about 60 kDa and about 100 kDa, or from between about 80 kDa and about 144 kDa, and a polydispersity ranging from 1 to about 5. 
     
     
         2 . The article of  claim 1 , wherein the silk fibroin fragments have a polydispersity from 1 to about 1.5, from about 1.5 to about 2.0, from about 2.0 to about 2.5, from about 2.5 to about 3.0, from about 3.0 to about 3.5, from about 3.5 to about 4.0, from about 4.0 to about 4.5, or from about 4.5 to about 5.0. 
     
     
         3 . The article of  claim 1 , wherein the silk fibroin fragments have a polydispersity from about 1.5 to about 3.0. 
     
     
         4 . The article of  claim 1 , wherein the silk fibroin fragments comprise one or more of low molecular weight silk fibroin fragments and medium molecular weight silk fibroin fragments. 
     
     
         5 . The article of any one of  claims 1  to  4 , further comprising about 0.01% (w/w) to about 10% (w/w) sericin relative to the silk fibroin fragments. 
     
     
         6 . The article of any one of  claims 1  to  5 , wherein the fabric comprises one or more of polyester, polyamide, polyaramid, polytetrafluoroethylene, polyethylene, polypropylene, polyurethane, silicone, mixtures of polyurethane and polyethyleneglycol, ultrahigh molecular weight polyethylene, high-performance polyethylene, nylon, LYCRA (polyester-polyurethane copolymer, also known as SPANDEX and elastomer), or a mixture thereof. 
     
     
         7 . The article of any one of  claims 1  to  6 , wherein the coating further comprises one or more of a wetting agent, an anti-foaming agent, a softener, a wicking agent, and an anti-microbial. 
     
     
         8 . The article of any one of  claims 1  to  7 , wherein the w/w ratio of silk fibroin fragments to the surfactant and/or emulsifier system in the coating is about 99:1, about 98:2, about 97:3, about 96:4, about 95:5, about 94:6, about 93:7, about 92:8, about 91:9, about 90:10, about 89:11, about 88:12, about 87:13, about 86:14, about 85:15, about 84:16, about 83:17, about 82:18, about 81:19, about 80:20, about 79:21, about 78:22, about 77:23, about 76:24, about 75:25, about 74:26, about 73:27, about 72:28, about 71:29, about 70:30, about 69:31, about 68:32, about 67:33, about 66:34, about 65:35, about 64:36, about 63:37, about 62:38, about 61:39, about 60:40, about 59:41, about 58:42, about 57:43, about 56:44, about 55:45, about 54:46, about 53:47, about 52:48, about 51:49, about 50:50, about 49:51, about 48:52, about 47:53, about 46:54, about 45:55, about 44:56, about 43:57, about 42:58, about 41:59, about 40:60, about 39:61, about 38:62, about 37:63, about 36:64, about 35:65, about 34:66, about 33:67, about 32:68, about 31:69, about 30:70, about 29:71, about 28:72, about 27:73, about 26:74, about 25:75, about 24:76, about 23:77, about 22:78, about 21:79, about 20:80, about 19:81, about 18:82, about 17:83, about 16:84, about 15:85, about 14:86, about 13:87, about 12:88, about 11:89, about 10:90, about 9:91, about 8:92, about 7:93, about 6:94, about 5:95, about 4:96, about 3:97, about 2:98, or about 1:99. 
     
     
         9 . The article of any one of  claims 1  to  7 , wherein the w/w ratio of silk fibroin fragments to the surfactant and/or emulsifier in the coating is about 1:1, about 1:2, about 1:4, about 1:8, about 1:16, or about 1:32. 
     
     
         10 . The article of any one of  claims 1  to  7 , wherein the w/w ratio of silk fibroin fragments to the surfactant and/or emulsifier system in the coating is about 1:1, about 1:2, about 1:3, about 1:4, about 1:5, about 1:6, about 1:7, about 1:8, about 1:9, about 1:10, about 1:11, about 1:12, about 1:13, about 1:14, about 1:15, about 1:16, about 1:17, about 1:18, about 1:19, about 1:20, about 1:21, about 1:22, about 1:23, about 1:24, about 1:25, about 1:26, about 1:27, about 1:28, about 1:29, about 1:30, about 1:31, or about 1:32. 
     
     
         11 . The article of any one of  claims 1  to  10 , wherein the surfactant and/or emulsifier system comprises one or more of polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan trioleate, polyoxyethylene castor oil, and any combination thereof. 
     
     
         12 . The article of any one of  claims 1  to  10 , wherein the surfactant and/or emulsifier system comprises one or more of polyoxyethylene (10-30) sorbitan monooleate, polyoxyethylene (10-30) sorbitan trioleate, polyoxyethylene (10-50) castor oil, and any combination thereof. 
     
     
         13 . The article of any one of  claims 1  to  10 , wherein the surfactant and/or emulsifier system comprises one or more of polyoxyethylene (20) sorbitan monooleate, polyoxyethylene (20) sorbitan trioleate, polyoxyethylene (29) castor oil, and any combination thereof. 
     
     
         14 . The article of any one of  claims 1  to  10 , wherein the surfactant and/or emulsifier system comprises one or more of polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monopalmitate, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan tristearate, and any combination thereof. 
     
     
         15 . The article of any one of  claims 1  to  10 , wherein the surfactant and/or emulsifier system comprises one or more of a sorbitan mono fatty acid, a sorbitan tri fatty acid, a castor oil, and any combination thereof. 
     
     
         16 . The article of any one of  claims 1  to  15 , wherein the surfactant and/or emulsifier system comprises one or more of coco glucoside, decyl glucoside, lauryl glucoside, sucrose cocoate, capryl/caprylyl glucoside, caprylyl/capryl glucoside, and any combination thereof. 
     
     
         17 . The article of any one of  claims 1  to  16 , wherein the surfactant and/or emulsifier system has an HLB between about 11 and about 13.50. 
     
     
         18 . The article of any one of  claims 1  to  16 , wherein the surfactant and/or emulsifier system has an HLB between about 11 and about 11.50, between about 11.50 and about 12, between about 12 and about 12.50, between about 12.50 and about 13, or between about 13 and about 13.50. 
     
     
         19 . The article of any one of  claims 1  to  18 , wherein the article has an improved moisture management comparative to a similar article comprising a similar fabric but no coating. 
     
     
         20 . The article of  claim 19 , wherein moisture management is assessed by a water absorbency test, a vertical wicking test, or a dry rate test. 
     
     
         21 . The article of any one of  claims 1  to  20 , wherein the article has an improved drapability comparative to a similar article comprising a similar fabric but no coating. 
     
     
         22 . The article of any one of  claims 1  to  21 , wherein the article has an improved smoothness comparative to a similar article comprising a similar fabric but no coating. 
     
     
         23 . The article of any one of  claims 1  to  22 , wherein the article has an improved hand feel comparative to a similar article comprising a similar fabric but no coating. 
     
     
         24 . The article of any one of  claims 1  to  23 , wherein the article has a lower charge density at a given pH value comparative to a similar article comprising a similar fabric but no coating. 
     
     
         25 . A method of making a silk fibroin coated fabric, comprising:
 applying to the fabric a solution comprising a surfactant and/or emulsifier system;   applying to the fabric a silk fibroin fragments solution; and   drying the fabric.   
     
     
         26 . A method of making a silk fibroin coated fabric, comprising:
 applying to the fabric a solution comprising a surfactant and/or emulsifier system and silk fibroin fragments; and   drying the fabric.   
     
     
         27 . The method of  claim 25  or  claim 26 , wherein the concentration of the silk fibroin fragments in a solution ranges from 0.01 g/L to about 100 g/L. 
     
     
         28 . The method of any one of  claims 25  to  27 , wherein the concentration of the surfactant and/or emulsifier system in a solution ranges from 0.01 g/L to about 100 g/L. 
     
     
         29 . The method of any one of  claims 25  to  28 , wherein the silk fibroin fragments have an average weight average molecular weight selected from between about 1 kDa and about 5 kDa, from between about 5 kDa and about 10 kDa, from between about 6 kDa and about 17 kDa, from between about 10 kDa and about 15 kDa, from between about 14 kDa and about 30 kDa, from between about 15 kDa and about 20 kDa, from between about 17 kDa and about 39 kDa, from between about 20 kDa and about 25 kDa, from between about 25 kDa and about 30 kDa, from between about 30 kDa and about 35 kDa, from between about 35 kDa and about 40 kDa, from between about 39 kDa and about 54 kDa, from between about 39 kDa and about 80 kDa, from between about 40 kDa and about 45 kDa, from between about 45 kDa and about 50 kDa, from between about 50 kDa and about 55 kDa, from between about 55 kDa and about 60 kDa, from between about 60 kDa and about 100 kDa, or from between about 80 kDa and about 144 kDa, and a polydispersity ranging from 1 to about 5. 
     
     
         30 . The method of any one of  claims 25  to  29 , wherein the silk fibroin fragments have a polydispersity from 1 to about 1.5, from about 1.5 to about 2.0, from about 2.0 to about 2.5, from about 2.5 to about 3.0, from about 3.0 to about 3.5, from about 3.5 to about 4.0, from about 4.0 to about 4.5, or from about 4.5 to about 5.0. 
     
     
         31 . The method of any one of  claims 25  to  29 , wherein the silk fibroin fragments have a polydispersity from about 1.5 to about 3.0. 
     
     
         32 . The method of any one of  claims 25  to  29 , wherein the silk fibroin fragments comprise one or more of low molecular weight silk fibroin fragments and medium molecular weight silk fibroin fragments. 
     
     
         33 . The method of any one of  claims 25  to  32 , wherein a solution further comprises about 0.01% (w/w) to about 10% (w/w) sericin relative to the silk fibroin fragments. 
     
     
         34 . The method of any one of  claims 25  to  33 , wherein the fabric comprises one or more of polyester, polyamide, polyaramid, polytetrafluoroethylene, polyethylene, polypropylene, polyurethane, silicone, mixtures of polyurethane and polyethyleneglycol, ultrahigh molecular weight polyethylene, high-performance polyethylene, nylon, LYCRA (polyester-polyurethane copolymer, also known as SPANDEX and elastomer), or a mixture thereof. 
     
     
         35 . The method of any one of  claims 25  to  34 , wherein a solution further comprises one or more of a wetting agent, an anti-foaming agent, a softener, a wicking agent, and an anti-microbial. 
     
     
         36 . The method of any one of  claims 25  to  35 , wherein the w/w ratio of silk fibroin fragments to the surfactant and/or emulsifier system is about 99:1, about 98:2, about 97:3, about 96:4, about 95:5, about 94:6, about 93:7, about 92:8, about 91:9, about 90:10, about 89:11, about 88:12, about 87:13, about 86:14, about 85:15, about 84:16, about 83:17, about 82:18, about 81:19, about 80:20, about 79:21, about 78:22, about 77:23, about 76:24, about 75:25, about 74:26, about 73:27, about 72:28, about 71:29, about 70:30, about 69:31, about 68:32, about 67:33, about 66:34, about 65:35, about 64:36, about 63:37, about 62:38, about 61:39, about 60:40, about 59:41, about 58:42, about 57:43, about 56:44, about 55:45, about 54:46, about 53:47, about 52:48, about 51:49, about 50:50, about 49:51, about 48:52, about 47:53, about 46:54, about 45:55, about 44:56, about 43:57, about 42:58, about 41:59, about 40:60, about 39:61, about 38:62, about 37:63, about 36:64, about 35:65, about 34:66, about 33:67, about 32:68, about 31:69, about 30:70, about 29:71, about 28:72, about 27:73, about 26:74, about 25:75, about 24:76, about 23:77, about 22:78, about 21:79, about 20:80, about 19:81, about 18:82, about 17:83, about 16:84, about 15:85, about 14:86, about 13:87, about 12:88, about 11:89, about 10:90, about 9:91, about 8:92, about 7:93, about 6:94, about 5:95, about 4:96, about 3:97, about 2:98, or about 1:99. 
     
     
         37 . The method of any one of  claims 25  to  35 , wherein the w/w ratio of silk fibroin fragments to the surfactant and/or emulsifier system is about 1:1, about 1:2, about 1:4, about 1:8, about 1:16, or about 1:32. 
     
     
         38 . The method of any one of  claims 25  to  35 , wherein the w/w ratio of silk fibroin fragments to the surfactant and/or emulsifier system is about 1:1, about 1:2, about 1:3, about 1:4, about 1:5, about 1:6, about 1:7, about 1:8, about 1:9, about 1:10, about 1:11, about 1:12, about 1:13, about 1:14, about 1:15, about 1:16, about 1:17, about 1:18, about 1:19, about 1:20, about 1:21, about 1:22, about 1:23, about 1:24, about 1:25, about 1:26, about 1:27, about 1:28, about 1:29, about 1:30, about 1:31, or about 1:32. 
     
     
         39 . The method of any one of  claims 25  to  38 , wherein the surfactant and/or emulsifier system comprises one or more of polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan trioleate, polyoxyethylene castor oil, and any combination thereof. 
     
     
         40 . The method of any one of  claims 25  to  38 , wherein the surfactant and/or emulsifier system comprises one or more of polyoxyethylene (10-30) sorbitan monooleate, polyoxyethylene (10-30) sorbitan trioleate, polyoxyethylene (10-50) castor oil, and any combination thereof. 
     
     
         41 . The method of any one of  claims 25  to  38 , wherein the surfactant and/or emulsifier system comprises one or more of polyoxyethylene (20) sorbitan monooleate, polyoxyethylene (20) sorbitan trioleate, polyoxyethylene (29) castor oil, and any combination thereof. 
     
     
         42 . The method of any one of  claims 25  to  38 , wherein the surfactant and/or emulsifier system comprises one or more of polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monopalmitate, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan tristearate, and any combination thereof. 
     
     
         43 . The method of any one of  claims 25  to  38 , wherein the surfactant and/or emulsifier system comprises one or more of a sorbitan mono fatty acid, a sorbitan tri fatty acid, a castor oil, and any combination thereof. 
     
     
         44 . The method of any one of  claims 25  to  43 , wherein the surfactant and/or emulsifier system comprises one or more of coco glucoside, decyl glucoside, lauryl glucoside, sucrose cocoate, capryl/caprylyl glucoside, caprylyl/capryl glucoside, and any combination thereof. 
     
     
         45 . The method of any one of  claims 25  to  44 , wherein the surfactant and/or emulsifier system has an HLB between about 11 and about 13.50. 
     
     
         46 . The method of any one of  claims 25  to  44 , wherein the surfactant and/or emulsifier system has an HLB between about 11 and about 11.50, between about 11.50 and about 12, between about 12 and about 12.50, between about 12.50 and about 13, or between about 13 and about 13.50. 
     
     
         47 . The method of any one of  claims 25  to  46 , wherein the drying comprises heating. 
     
     
         48 . The method of any one of  claims 25  to  47 , wherein the pH of a solution is acidic. 
     
     
         49 . The method of any one of  claims 25  to  47 , wherein the pH of a solution is between about 3.5 and about 4, between about 4 and about 4.5, between about 4.5 and about 5, between about 5 and about 5.5, or between about 5.5 and about 6. 
     
     
         50 . An article prepared by the method of any one of  claims 25  to  49 . 
     
     
         51 . The article of  claim 50 , wherein the article has an improved moisture management comparative to a similar article comprising a similar fabric but no coating. 
     
     
         52 . The article of  claim 51 , wherein moisture management is assessed by a water absorbency test, a vertical wicking test, or a dry rate test. 
     
     
         53 . The article of any one of  claims 50  to  52 , wherein the article has an improved drapability comparative to a similar article comprising a similar fabric but no coating. 
     
     
         54 . The article of any one of  claims 50  to  53 , wherein the article has an improved smoothness comparative to a similar article comprising a similar fabric but no coating. 
     
     
         55 . The article of any one of  claims 50  to  54 , wherein the article has an improved hand feel comparative to a similar article comprising a similar fabric but no coating. 
     
     
         56 . The article of any one of  claims 50  to  55 , wherein the article has a lower charge density at a given pH value comparative to a similar article comprising a similar fabric but no coating.