Composition for alleviating, treating, or preventing muscular diseases, or improving muscular functions, containing korean mint extract or tilianin as active ingredient

Abstract

The present disclosure relates to a composition for alleviating, treating or preventing muscular diseases or improving muscular functions, which contains a Korean mint extract or tilianin as an active ingredient. The Korean mint or tilianin according to the present disclosure has effects of increasing the activity of mTOR, which is involved in muscle protein synthesis, and reducing mRNA expression of MuRF-1 and atrogin-1, which are involved in muscle protein degradation. Accordingly, it can be usefully used for prevention, amelioration or treatment of various muscular diseases such as sarcopenia, muscular atrophy, muscular dystrophy, atony, muscular degeneration, myasthenia, cachexia, etc. by increasing muscle mass and improving muscular functions.

We claim: 
     
         1 . A method for treating or preventing a muscular disease in a subject in need thereof, comprising:
 administering a composition to the subject,   wherein the composition comprises a Korean mint extract or tilianin represented by Chemical Formula 1 as an active ingredient:   
       
         
           
           
               
               
           
         
       
     
     
         2 . The method according to  claim 1 , wherein the Korean mint extract is obtained by extracting Korean mint with one or more solvent selected from a group consisting of water, a C 1-6  organic solvent, an ultra-high-pressure subcritical fluid and a supercritical fluid. 
     
     
         3 . The method according to  claim 2 , wherein the organic solvent is at least one solvent selected from a group consisting of a C 1-6  alcohol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, hexane, cyclohexane and petroleum ether. 
     
     
         4 . The method according to  claim 1 , wherein the muscular disease is one or more disease selected from a group consisting of sarcopenia, muscular atrophy, muscular dystrophy, atony, muscular degeneration, myasthenia and cachexia. 
     
     
         5 . The method according to  claim 1 , wherein the composition is a food composition, a pharmaceutical composition, a cosmetic composition, or a feed composition. 
     
     
         6 . A method for improving muscle mass and muscular strength in a subject in need thereof, comprising:
 administering a composition to the subject,   wherein the composition comprising a Korean mint extract or tilianin represented by Chemical Formula 1 as an active ingredient:   
       
         
           
           
               
               
           
         
       
     
     
         7 . (canceled)