Drug addiction treatment and menthol transdermal delivery systems and methods

Abstract

The present disclosure relates to compositions, including, transdermal delivery systems useful as topical analgesics including an effective amount of a compound (e.g., psilocybin) for treating drug addiction (e.g. opioid addiction) and menthol and optionally cannabinoids wherein the menthol component can be a stabilized menthol composition comprising menthol and at least one menthol stabilizer compound including undecylenic acid methyl ester, undecylenic acid or a salt of undecylenic acid.

1 . A transdermal delivery system, comprising:
 an absorbent material including
 menthol; 
 an effective amount of a compound for treating drug addiction; 
 a carrier solvent; 
 an absorbent polymer; and 
 a surfactant. 
   
     
     
         2 . The transdermal delivery system of  claim 1 , further including at least one cannabinoid. 
     
     
         3 . The transdermal delivery system of  claim 1 , wherein the absorbent polymer is a superabsorbent polymer. 
     
     
         4 . The transdermal delivery system of  claim 1 , wherein the carrier solvent is coconut oil, medium chain triglycerides, olive oil, castor oil, canola oil, triacetin, corn oil, petrolatum, mineral oil, shea butter or mixtures thereof. 
     
     
         5 . The transdermal delivery system of  claim 2 , wherein the at least one cannabinoid is full spectrum hemp oil. 
     
     
         6 . The transdermal delivery system of  claim 1 , wherein the compound for treating drug addiction is psilocybin. 
     
     
         7 . The transdermal delivery system of  claim 1 , wherein the compound for treating drug addiction is for treating opioid addition. 
     
     
         8 . A transdermal delivery system, comprising:
 a backing material includes a first side and a second side, the second side at least a portion of which including a topically acceptable adhesive;   an absorbent material layer includes a first side and a second side and   
       wherein the first side of the absorbent material layer is positioned adjacent the second side of the backing material, the absorbent material including
 menthol; 
 an effective amount of a compound for treating drug addiction; 
 a carrier solvent; and 
 an absorbent polymer; and 
 a release layer in contact with a portion of the second side of the backing material, 
 wherein the absorbent material is positioned in a cavity in between the backing layer and the release layer. 
 
     
     
         9 . The transdermal delivery system of  claim 8 , further including at least one cannabinoid. 
     
     
         10 . The transdermal delivery system of  claim 8 , wherein the compound for treating drug addiction is psilocybin. 
     
     
         11 . The transdermal delivery system of  claim 8 , wherein the compound for treating drug addiction is for treating opioid addition. 
     
     
         12 . The transdermal delivery system of  claim 8 , wherein the absorbent polymer is a superabsorbent polymer. 
     
     
         13 . The transdermal delivery system of  claim 8 , wherein the carrier solvent is coconut oil, medium chain triglycerides, olive oil, castor oil, canola oil, triacetin, corn oil, petrolatum, mineral oil, shea butter or mixtures thereof. 
     
     
         14 . A method of treating drug addiction of a human patient using a transdermal delivery system, the transdermal delivery system comprising:
 an absorbent material including a first side and a second side, the absorbent material including
 at least one 
 cannabinoid; menthol; 
 an effective amount of a compound for treating drug addiction; 
 a carrier solvent; 
 an absorbent polymer; and 
 a surfactant, 
   the method comprising:
 topically applying the first side or the second side of the absorbent material to a skin surface of a body part of the human patient. 
   
     
     
         15 . The method of  claim 14 , wherein the transdermal delivery system further includes at least one cannabinoid. 
     
     
         16 . The method of  claim 14 , wherein the compound for treating drug addiction ispsilocybin. 
     
     
         17 . The method of  claim 14 , wherein the method of treating drug addiction is for treating opioid addition. 
     
     
         18 . The method of  claim 14 , wherein the absorbent polymer is a superabsorbentpolymer. 
     
     
         19 . The method of  claim 14 , wherein the carrier solvent is coconut oil, medium chain triglycerides, olive oil, castor oil, canola oil, triacetin, corn oil, petrolatum, mineral oil, shea butter or mixtures thereof. 
     
     
         20 . The method of  claim 14 , wherein the transdermal delivery system further includes a backing layer comprising an adhesive side and a non-adhesive side such that the adhesive side covers the other of the first side or the second side of the absorbent material and contacting at least a portion of the adhesive side of the backing layer with the skin surface.