Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof

Abstract

There are provided various compounds and compositions comprising polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds and compositions can be useful for use in cellular senescence prevention in a subject in need thereof or for slowing/delaying cellular senescence in a subject in need thereof. These compounds and compositions comprise at least one compound chosen from

What is claimed is: 
     
         1 . At least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV): 
       
         
           
           
               
               
           
         
         for use in cellular senescence prevention in a subject in need thereof. 
       
     
     
         2 . At least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV): 
       
         
           
           
               
               
           
         
         for use as cellular senescence prevention agent in a subject in need thereof. 
       
     
     
         3 . At least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV), for use in a method for slowing/delaying cellular senescence in a subject in need thereof. 
     
     
         4 . At least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV), for use in slowing/delaying cellular senescence in a subject in need thereof. 
     
     
         5 . The at least one compound of any one of  claims 1 to 4 , wherein said at least one compound is said compound of formula (I). 
     
     
         6 . The at least one compound of any one of  claims 1 to 4 , wherein said at least one compound is said compound of formula (II). 
     
     
         7 . The at least one compound of any one of  claims 1 to 4 , wherein said at least one compound is said compound of formula (III). 
     
     
         8 . The at least one compound of any one of  claims 1 to 4 , wherein said at least one compound is said compound of formula (IV). 
     
     
         9 . The at least one compound of any one of  claims 1 to 4 , wherein said at least one compound is said compound of formula (I), said compound of formula (III) and said compound of formula (IV). 
     
     
         10 . The at least one compound of any one of  claims 1 to 4 , wherein said at least one compound is said compound of formula (I) and said compound of formula (IV). 
     
     
         11 . The at least one compound of any one of  claims 1 to 4 , wherein said at least one compound is said compound of formula (I) and said compound of formula (III). 
     
     
         12 . The at least one compound of any one of  claims 1 to 4 , wherein said at least one compound is said compound of formula (III) and said compound of formula (IV). 
     
     
         13 . The at least one compound of any one of  claims 1 to 12 , for use in combination with at least one lipid. 
     
     
         14 . The at least one compound of  claim 13 , wherein said at least one lipid and said at least one compound are for simultaneous administration. 
     
     
         15 . The at least one compound of  claim 13 , wherein said at least one lipid and said at least one compound are for separate administration. 
     
     
         16 . The at least one compound of any one of  claims 1 to 12 , for use in combination with at least one polyphenol. 
     
     
         17 . The at least one compound of  claim 16 , wherein said at least one polyphenol and said at least one compound are for simultaneous administration. 
     
     
         18 . The at least one compound of  claim 16 , wherein said at least one polyphenol and said at least one compound are for separate administration. 
     
     
         19 . The at least one compound of  claim 16, 17 or 18 , wherein said at least one polyphenol is chosen from flavonoids anthocyanidins, flavan-3-ols, epigallocatechin gallate, fisetin, flavonols, quercetin, flavanones, flavones, isoflavones, tannic acid, quercitannic acid, gallotannic acid and mixtures thereof. 
     
     
         20 . The at least one compound of  claim 16, 17 or 18 , wherein said at least one polyphenol is chosen from epigallocatechin gallate, fisetin, quercetin, and mixtures thereof. 
     
     
         21 . The at least one compound of any one of  claims 1 to 20 , wherein the slowing/delaying cellular senescence comprises slowing/delaying cellular senescence of peripheral blood mononuclear cells. 
     
     
         22 . The at least one compound of any one of  claims 1 to 20 , wherein the slowing/delaying cellular senescence comprises decreasing % of senescent peripheral blood mononuclear cells. 
     
     
         23 . The at least one compound of any one of  claims 1 to 20 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 25% of senescent peripheral blood mononuclear cells in a period of time of about 21 days. 
     
     
         24 . The at least one compound of any one of  claims 1 to 20 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 25% of senescent peripheral blood mononuclear cells in a period of time of about 14 days. 
     
     
         25 . The at least one compound of any one of  claims 1 to 20 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 25% of senescent peripheral blood mononuclear cells in a period of time of about 7 days. 
     
     
         26 . The at least one compound of any one of  claims 1 to 20 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 33% of senescent peripheral blood mononuclear cells in a period of time of about 21 days. 
     
     
         27 . The at least one compound of any one of  claims 1 to 20 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 33% of senescent peripheral blood mononuclear cells in a period of time of about 14 days. 
     
     
         28 . The at least one compound of any one of  claims 1 to 20 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 33% of senescent peripheral blood mononuclear cells in a period of time of about 7 days. 
     
     
         29 . Use of at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV), for cellular senescence prevention in a subject in need thereof. 
     
     
         30 . Use of at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV), as a cellular senescence prevention agent. 
     
     
         31 . Use of at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV), for slowing/delaying cellular senescence in a subject in need thereof. 
     
     
         32 . Use of at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV), in the manufacture of a medicament for cellular senescence prevention in a subject in need thereof. 
     
     
         33 . Use of at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV), in the manufacture of a medicament for slowing/delaying cellular senescence in a subject in need thereof. 
     
     
         34 . The use of any one of  claims 29 to 33 , wherein said at least one compound is said compound of formula (I). 
     
     
         35 . The use of any one of  claims 29 to 33 , wherein said at least one compound is said compound of formula (II). 
     
     
         36 . The use of any one of  claims 29 to 33 , wherein said at least one compound is said compound of formula (III). 
     
     
         37 . The use of any one of  claims 29 to 33 , wherein said at least one compound is said compound of formula (IV). 
     
     
         38 . The use of any one of  claims 29 to 33 , wherein said at least one compound is said compound of formula (I), said compound of formula (III) and said compound of formula (IV). 
     
     
         39 . The use of any one of  claims 29 to 33 , wherein said at least one compound is said compound of formula (I) and said compound of formula (IV). 
     
     
         40 . The use of any one of  claims 29 to 33 , wherein said at least one compound is said compound of formula (I) and said compound of formula (III). 
     
     
         41 . The use of any one of  claims 29 to 33 , wherein said at least one compound is said compound of formula (III) and said compound of formula (IV). 
     
     
         42 . The use of any one of  claims 29 to 33 , for use in combination with at least one lipid. 
     
     
         43 . The use of  claim 34 , wherein said at least one lipid and said at least one compound are for simultaneous administration. 
     
     
         44 . The use of  claim 42 , wherein said at least one lipid and said at least one compound are for separate administration. 
     
     
         45 . The use of any one of  claims 29 to 41 , for use in combination with at least one polyphenol. 
     
     
         46 . The use of  claim 45 , wherein said at least one polyphenol and said at least one compound are for simultaneous administration. 
     
     
         47 . The use of  claim 45 , wherein said at least one polyphenol and said at least one compound are for separate administration. 
     
     
         48 . The use of  claim 45, 46 or 47 , wherein said at least one polyphenol is chosen from flavonoids anthocyanidins, flavan-3-ols, epigallocatechin gallate, fisetin, flavonols, quercetin, flavanones, flavones, isoflavones, tannic acid, quercitannic acid, gallotannic acid and mixtures thereof. 
     
     
         49 . The use of  claim 45, 46 or 47 , wherein said at least one polyphenol is chosen from epigallocatechin gallate, fisetin, quercetin, and mixtures thereof. 
     
     
         50 . The use of any one of  claims 45 to 49 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof at a suitable amount. 
     
     
         51 . The use of any one of  claims 45 to 49 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 50 mg/day to about 5000 mg/day. 
     
     
         52 . The use of any one of  claims 45 to 49 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 50 mg/day to about 500 mg/day. 
     
     
         53 . The use of any one of  claims 45 to 49 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 1 mg/kg/day to about 100 mg/kg/day. 
     
     
         54 . The use of any one of  claims 45 to 49 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 1 mg/kg/day to about 50 mg/kg/day. 
     
     
         55 . The use of any one of  claims 45 to 49 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 2 mg/kg/day to about 20 mg/kg/day. 
     
     
         56 . The use of any one of  claims 45 to 49 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered for a period of time of at least 1 month. 
     
     
         57 . The use of any one of  claims 45 to 49 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered for a period of time of at least 4 months. 
     
     
         58 . The use of any one of  claims 45 to 49 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered for a period of time of about 1 month to about 12 months. 
     
     
         59 . The use of any one of  claims 45 to 58 , wherein said at least one polyphenol is administered to a patient in need thereof at a suitable amount. 
     
     
         60 . The use of any one of  claims 45 to 58 , wherein said at least one polyphenol is administered to a patient in need thereof in an amount of about 50 mg/day to about 5000 mg/day. 
     
     
         61 . The use of any one of  claims 45 to 58 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 50 mg/day to about 500 mg/day. 
     
     
         62 . The use of any one of  claims 45 to 58 , wherein said at least one polyphenol is administered to a patient in need thereof in an amount of about 1 mg/kg/day to about 100 mg/kg/day. 
     
     
         63 . The use of any one of  claims 45 to 58 , wherein said at least one polyphenol is administered to a patient in need thereof in an amount of about 1 mg/kg/day to about 50 mg/kg/day. 
     
     
         64 . The use of any one of  claims 45 to 58 , wherein said at least one polyphenol is administered to a patient in need thereof in an amount of about 2 mg/kg/day to about 20 mg/kg/day. 
     
     
         65 . The use of any one of  claims 45 to 64 , wherein said at least one polyphenol is administered for a period of time of at least 2 days. 
     
     
         66 . The use of any one of  claims 45 to 64 , wherein said at least one polyphenol is administered for a period of time of at least 10 days. 
     
     
         67 . The use of any one of  claims 45 to 64 , wherein said at least one polyphenol is administered for a period of time of about 2 days to about 15 days. 
     
     
         68 . The use of any one of  claims 45 to 64 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof for a period of time of about 1 to 12 months, then said administration is discontinued and subsequent to discontinuation, said at least one polyphenol is administered for a period of time of about 1 day to about 15 days. 
     
     
         69 . The use of any one of  claims 45 to 68 , wherein the slowing/delaying cellular senescence comprises slowing/delaying cellular senescence of peripheral blood mononuclear cells. 
     
     
         70 . The use of any one of  claims 45 to 68 , wherein the slowing/delaying cellular senescence comprises decreasing % of senescent peripheral blood mononuclear cells. 
     
     
         71 . The use of any one of  claims 45 to 68 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 25% of senescent peripheral blood mononuclear cells in a period of time of about 21 days. 
     
     
         72 . The use of any one of  claims 45 to 68 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 25% of senescent peripheral blood mononuclear cells in a period of time of about 14 days. 
     
     
         73 . The use of any one of  claims 45 to 68 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 25% of senescent peripheral blood mononuclear cells in a period of time of about 7 days. 
     
     
         74 . The use of any one of  claims 45 to 68 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 33% of senescent peripheral blood mononuclear cells in a period of time of about 21 days. 
     
     
         75 . The use of any one of  claims 45 to 68 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 33% of senescent peripheral blood mononuclear cells in a period of time of about 14 days. 
     
     
         76 . The use of any one of  claims 45 to 68 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 33% of senescent peripheral blood mononuclear cells in a period of time of about 7 days. 
     
     
         77 . A method of using at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV), said method comprising administering an effective amount of said at least one compound for cellular senescence prevention. 
     
     
         78 . A method for slowing/delaying cellular senescence of a subject in need thereof comprising administering to the subject an effective amount of at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV). 
     
     
         79 . The method of any one of  claims 77 to 78 , wherein said at least one compound is said compound of formula (I). 
     
     
         80 . The method of any one of  claims 77 to 78 , wherein said at least one compound is said compound of formula (II). 
     
     
         81 . The method of any one of  claims 77 to 78 , wherein said at least one compound is said compound of formula (III). 
     
     
         82 . The method of any one of  claims 77 to 78 , wherein said at least one compound is said compound of formula (IV). 
     
     
         83 . The method of any one of  claims 77 to 78 , wherein said at least one compound is said compound of formula (I), said compound of formula (III) and said compound of formula (IV). 
     
     
         84 . The method of any one of  claims 77 to 78 , wherein said at least one compound is said compound of formula (I) and said compound of formula (IV). 
     
     
         85 . The method of any one of  claims 77 to 78 , wherein said at least one compound is said compound of formula (I) and said compound of formula (III). 
     
     
         86 . The method of any one of  claims 77 to 78 , wherein said at least one compound is said compound of formula (III) and said compound of formula (IV). 
     
     
         87 . The method of any one of  claims 77 to 78 , wherein said at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered in combination with at least one lipid. 
     
     
         88 . The method of any one of claims  77  to  876 , wherein said at least one lipid and said at least one compound are administered simultaneously. 
     
     
         89 . The method of any one of  claims 77 to 87 , wherein said at least one lipid and said at least one compound are administered separately. 
     
     
         90 . The method of any one of  claims 77 to 87 , wherein said at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered in combination with at least one polyphenol. 
     
     
         91 . The method of any one of  claim 90 , wherein said at least one polyphenol and said at least one compound are administered simultaneously. 
     
     
         92 . The method of any one of  claim 90 , wherein said at least one polyphenol and said at least one compound are administered separately. 
     
     
         93 . The method of  claim 90, 91 or 92 , wherein said at least one polyphenol is chosen from flavonoids anthocyanidins, flavan-3-ols, epigallocatechin gallate, fisetin, flavonols, quercetin, flavanones, flavones, isoflavones, tannic acid, quercitannic acid, gallotannic acid and mixtures thereof. 
     
     
         94 . The method of  claim 90, 91 or 92 , wherein said at least one polyphenol is chosen from epigallocatechin gallate, fisetin, quercetin, and mixtures thereof. 
     
     
         95 . The method of any one of  claims 90 to 94 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof at a suitable amount. 
     
     
         96 . The method of any one of  claims 90 to 94 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 50 mg/day to about 5000 mg/day. 
     
     
         97 . The method of any one of  claims 90 to 94 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 50 mg/day to about 500 mg/day. 
     
     
         98 . The method of any one of  claims 90 to 94 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 1 mg/kg/day to about 100 mg/kg/day. 
     
     
         99 . The method of any one of  claims 90 to 94 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 1 mg/kg/day to about 50 mg/kg/day. 
     
     
         100 . The method of any one of  claims 90 to 94 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof in an amount of about 2 mg/kg/day to about 20 mg/kg/day. 
     
     
         101 . The method of any one of claims  90  to  101 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered for a period of time of at least 1 month. 
     
     
         102 . The method of any one of  claims 90 to 101 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered for a period of time of at least 4 months. 
     
     
         103 . The method of any one of  claims 90 to 101 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered for a period of time of about 1 month to about 12 months. 
     
     
         104 . The method of any one of  claims 90 to 101 , wherein said at least one polyphenol is administered to a patient in need thereof at a suitable amount. 
     
     
         105 . The method of any one of  claims 90 to 104 , wherein said at least one polyphenol is administered to a patient in need thereof in an amount of about 50 mg/day to about 5000 mg/day. 
     
     
         106 . The method of any one of  claims 90 to 104 , wherein said at least one polyphenol is administered to a patient in need thereof in an amount of about 50 mg/day to about 500 mg/day. 
     
     
         107 . The method of any one of  claims 90 to 104 , wherein said at least one polyphenol is administered to a patient in need thereof in an amount of about 1 mg/kg/day to about 100 mg/kg/day. 
     
     
         108 . The method of any one of  claims 90 to 104 , wherein said at least one polyphenol is administered to a patient in need thereof in an amount of about 1 mg/kg/day to about 50 mg/kg/day. 
     
     
         109 . The method of any one of  claims 90 to 104 , wherein said at least one polyphenol is administered to a patient in need thereof in an amount of about 2 mg/kg/day to about 20 mg/kg/day. 
     
     
         110 . The method of any one of  claims 90 to 109 , wherein said at least one polyphenol is administered for a period of time of at least 2 days. 
     
     
         111 . The method of any one of  claims 90 to 109 , wherein said at least one polyphenol is administered for a period of time of at least 10 days. 
     
     
         112 . The method of any one of  claims 90 to 109 , wherein said at least one polyphenol is administered for a period of time of about 2 days to about 15 days. 
     
     
         113 . The method of any one of  claims 90 to 109 , wherein said compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV) is administered to a patient in need thereof for a period of time of about 1 to 12 months, then said administration is discontinued and subsequent to discontinuation, said at least one polyphenol is administered for a period of time of about 1 day to about 15 days. 
     
     
         114 . The method of any one of  claims 90 to 113 , wherein the slowing/delaying cellular senescence comprises slowing/delaying cellular senescence of peripheral blood mononuclear cells. 
     
     
         115 . The method of any one of  claims 90 to 113 , wherein the slowing/delaying cellular senescence comprises decreasing % of senescent peripheral blood mononuclear cells. 
     
     
         116 . The method of any one of  claims 90 to 113 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 25% of senescent peripheral blood mononuclear cells in a period of time of about 21 days. 
     
     
         117 . The method of any one of  claims 90 to 113 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 25% of senescent peripheral blood mononuclear cells in a period of time of about 14 days. 
     
     
         118 . The method of any one of  claims 90 to 113 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 25% of senescent peripheral blood mononuclear cells in a period of time of about 7 days. 
     
     
         119 . The method of any one of  claims 90 to 113 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 33% of senescent peripheral blood mononuclear cells in a period of time of about 21 days. 
     
     
         120 . The method of any one of  claims 90 to 113 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 33% of senescent peripheral blood mononuclear cells in a period of time of about 14 days. 
     
     
         121 . The method of any one of  claims 90 to 113 , wherein the slowing/delaying cellular senescence comprises decreasing at least about 33% of senescent peripheral blood mononuclear cells in a period of time of about 7 days. 
     
     
         122 . A composition comprising:
 (i) at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV); and   (ii) at least one lipid.   
     
     
         123 . The composition of  claim 122 , wherein said at least one lipid is chosen from marine oil, fish oil, fish oil concentrate, re-esterified fish oil, re-esterified concentrated fish oil, fatty acids ethyl esters, fatty acids esters, monoglycerides, diglycerides, triglycerides and phospholipids. 
     
     
         124 . The composition of any one of  claims 122 to 123 , wherein said at least one compound is said compound of formula (I). 
     
     
         125 . The composition of any one of  claims 122 to 123 , wherein said at least one compound is said compound of formula (II). 
     
     
         126 . The composition of any one of  claims 122 to 123 , wherein said at least one compound is said compound of formula (III). 
     
     
         127 . The composition of any one of  claims 122 to 123 , wherein said at least one compound is said compound of formula (IV). 
     
     
         128 . The composition of any one of  claims 122 to 123 , wherein said at least one compound is said compound of formula (I), said compound of formula (III) and said compound of formula (IV). 
     
     
         129 . The composition of any one of  claims 122 to 123 , wherein said at least one compound is said compound of formula (I) and said compound of formula (IV). 
     
     
         130 . The composition of any one of  claims 122 to 123 , wherein said at least one compound is said compound of formula (I) and said compound of formula (III). 
     
     
         131 . The composition of any one of  claims 122 to 123 , wherein said at least one compound is said compound of formula (III) and said compound of formula (IV). 
     
     
         132 . A composition comprising:
 (i) at least one compound chosen from compound of formula (I), compound of formula (II), compound of formula (III) and compound of formula (IV); and   (ii) at least one polyphenol.   
     
     
         133 . The composition of  claim 132 , wherein said at least one polyphenol is chosen from flavonoids anthocyanidins, flavan-3-ols, epigallocatechin gallate, fisetin, flavonols, quercetin, flavanones, flavones, isoflavones, tannic acid, quercitannic acid, gallotannic acid and the Blend of Fisetin/Quercetin (1:5), microalgae polyphenol, macroalgae polyphenol, plants polyphenol, protists polyphenol and pharmaceutically acceptable salts thereof. 
     
     
         134 . The composition of  claim 132 , wherein said at least one polyphenol is chosen from flavonoids anthocyanidins, flavan-3-ols, epigallocatechin gallate, fisetin, flavonols, quercetin, flavanones, flavones, isoflavones, tannic acid, quercitannic acid, gallotannic acid and mixtures thereof. 
     
     
         135 . The composition of  claim 132 , wherein said at least one polyphenol is chosen from epigallocatechin gallate, fisetin, quercetin, and mixtures thereof. 
     
     
         136 . The composition of  claim 132 , wherein said at least one polyphenol is chosen from microalgae polyphenols, macroalgae polyphenols, plants polyphenols and protists polyphenols. 
     
     
         137 . The composition of any one of  claims 132 to 136 , wherein said at least one compound is said compound of formula (I). 
     
     
         138 . The composition of any one of  claims 132 to 136 , wherein said at least one compound is said compound of formula (II). 
     
     
         139 . The composition of any one of  claims 132 to 136 , wherein said at least one compound is said compound of formula (III). 
     
     
         140 . The composition of any one of  claims 132 to 136 , wherein said at least one compound is said compound of formula (IV). 
     
     
         141 . The composition of any one of  claims 132 to 136 , wherein said at least one compound is said compound of formula (I), said compound of formula (III) and said compound of formula (IV). 
     
     
         142 . The composition of any one of  claims 132 to 136 , wherein said at least one compound is said compound of formula (I) and said compound of formula (IV). 
     
     
         143 . The composition of any one of  claims 132 to 136 , wherein said at least one compound is said compound of formula (I) and said compound of formula (III). 
     
     
         144 . The composition of any one of  claims 132 to 136 , wherein said at least one compound is said compound of formula (III) and said compound of formula (IV). 
     
     
         145 . The at least one compound of  claim 16, 17 or 18 , wherein said at least one polyphenol is chosen from microalgae polyphenols, macroalgae polyphenols, plants polyphenols and protists polyphenols. 
     
     
         146 . The use of  claim 45, 46 or 47 , wherein said at least one polyphenol is chosen from microalgae polyphenols, macroalgae polyphenols, plants polyphenols and protists polyphenols. 
     
     
         147 . The method of  claim 90, 91 or 92 , wherein said at least one polyphenol is chosen from microalgae polyphenols, macroalgae polyphenols, plants polyphenols and protists polyphenols.