Oral composition comprising receptor modulator

Abstract

The disclosure provides a composition configured for oral use, the composition including at least one active ingredient, an ion channel modulator which binds to one or more receptors selected from TRPA1, TRPV1, TRPV3, TRPM8, NaV1.7, and combinations thereof; and at least one filler.

1 . A composition configured for oral use, the composition comprising:
 at least one active ingredient selected from the group consisting of botanical materials, stimulants, amino acids, vitamins, antioxidants, nutraceuticals, cannabinoids, cannabimimetics, terpenes, pharmaceutical agents, and combinations thereof;   an ion channel modulator selected from the group consisting of TRPA1 agonists, TRPA1 antagonists, TRPA1 channel blockers, TRPV1 agonists, TRPV3 agonists, TRPM8 agonists, NaV1.7 antagonists, and combinations thereof; and   at least one filler.   
     
     
         2 . The composition of  claim 1 , wherein the ion channel modulator is selected from the group consisting of TRPA1 agonists, TRPM8 agonists, TRPV1 agonists, TRPV3 agonists, and combinations thereof. 
     
     
         3 . The composition of  claim 1 , wherein the ion channel modulator is a TRPA1 antagonist or a TRPA1 channel blocker. 
     
     
         4 . The composition of  claim 1 , wherein the active ingredient comprises nicotine. 
     
     
         5 . The composition of  claim 4 , wherein the nicotine is present in an amount of from about 0.001 to about 10% by weight of the composition, calculated as the free base and based on the total weight of the composition. 
     
     
         6 . The composition of  claim 1 , wherein the at least one filler comprises a cellulose material. 
     
     
         7 . The composition of  claim 6 , wherein the cellulose material comprises microcrystalline cellulose. 
     
     
         8 . The composition of  claim 6 , wherein the at least one filler further comprises a cellulose derivative in an amount by weight of from about 1% to about 3%, based on the total weight of the composition. 
     
     
         9 . The composition of  claim 8 , wherein the cellulose derivative is hydroxypropyl cellulose. 
     
     
         10 . The composition of  claim 1 , further comprising one or more flavoring agents, one or more salts, one or more sweeteners, one or more binding agents, one or more humectants, one or more gums, a tobacco material, or combinations thereof. 
     
     
         11 . The composition of  claim 1 , comprising no more than about 10% by weight of a tobacco material, excluding any nicotine component present, based on the total weight of the composition. 
     
     
         12 . The composition of  claim 1 , wherein the composition is free of tobacco material. 
     
     
         13 . The composition of  claim 1 , enclosed in a pouch to form a pouched product, the composition optionally being in a granular form. 
     
     
         14 . The composition of  claim 1 , in the form of a gel, pastille, gum, chew, melt, tablet, lozenge, granular material, or powder.