Microneedle particles and method for preparing microneedle particles

Abstract

The present disclosure relates to microneedle particles and a method for preparing microneedle particles.

1 . A method of preparing microneedle particles, the method comprising:
 providing a particle assembly having a plurality of microneedle particles on an upper surface of a first film; and   separating the microneedle particles from the particle assembly,   wherein the separating of the microneedle particles from the particle assembly includes weakening adhesion between the first film and the microneedle particles.   
     
     
         2 . The method of  claim 1 , wherein the first film includes a water-soluble film. 
     
     
         3 . The method of  claim 2 , wherein the first film includes one or a mixture of two or more selected from polyvinylpyrrolidone, polyvinyl alcohol, cellulose polymer, dextran, gelatin, glycerin, polyethylene glycol, polysorbate, propylene glycol, povidone, carbomer, gum ghatti, guar gum, glucomannan, glucosamine, dammer resin, rennet casein, locust bean gum, microfibrillatedcellulose, psyllium seed gum, xanthan gum, arabino galactan, gum arabic, alginic acid, gelatin, gellan gum, carrageenan, karaya gum, curdlan, chitosan, chitin, tara gum, tamarind gum, tragacanth gum, furcelleran, pectin or pullulan, hydroxypropyl methylcellulose (HPMC), hydroxyalkyl cellulose, ethyl hydroxyethyl cellulose, alkyl cellulose, gluten, soy polysaccharides, polacrilin potassium, sodium starch glycolate, crospovidone, croscarmellose sodium, bentonite, hydroxypropyl starch, sodium carboxymethyl cellulose, sodium alginate, sodium lauryl sulfate, silicic anhydride, hydroxypropyl cellulose, polyvinyl acetate, amylose, sodium hydrogen carbonate, amylopectin, sodium polyphosphate, and aluminium magnesium silicate. 
     
     
         4 . The method of  claim 1 , wherein the particle assembly further includes a second film attached to a lower surface of the first film. 
     
     
         5 . The method of  claim 4 , wherein the second film includes a hydrophobic film or a hydrophilic film. 
     
     
         6 . The method of  claim 4 , wherein the second film includes one or a mixture of two or more selected from high density polyethylene (HDPE), polystyrene (PS), polypropylene (PP), polyethylene terephthalate (PET), and polyethylene naphthalate (PEN). 
     
     
         7 . The method of  claim 4 , wherein adhesion between the first film and the microneedle particles is higher than adhesion between the second film and the microneedle particles. 
     
     
         8 . The method of  claim 1 , wherein the weakening of the adhesion between the first film and the microneedle particles includes treating the particle assembly with a solvent to dissolve or swell the first film. 
     
     
         9 . The method of  claim 8 , wherein the solvent does not dissolve the microneedle particles. 
     
     
         10 . The method of  claim 8 , wherein the solvent includes one or more selected from distilled water, ethanol, acetone, oleyl alcohol, isoparaffin, and dipropylene glycol. 
     
     
         11 . The method of  claim 8 , further comprising, when the first film is swelled with the solvent, applying a transverse force to the microneedle particles to separate the microneedle particles from the first film. 
     
     
         12 . The method of  claim 8 , further comprising:
 when the first film is dissolved with the solvent, filtering and extracting the microneedle particles from the solvent; and   drying the microneedle particles.   
     
     
         13 . The method of  claim 8 , wherein, when the particle assembly is treated with the solvent, the particle assembly is treated using the solvent in a liquid state or the solvent is vaporized to treat the particle assembly with the solvent in a gaseous state. 
     
     
         14 . Microneedle particles prepared using the method of preparing microneedle particles of  claim 1 . 
     
     
         15 . The method of  claim 4 , wherein the weakening of the adhesion between the first film and the microneedle particles includes treating the particle assembly with a solvent to dissolve or swell the first film.