Colonic purgative composition

Abstract

The present invention relates to a colonic purgative composition and a preparation method therefor, and more specifically, to a colonic purgative composition comprising sodium picosulfate, potassium sulfate and magnesium sulfate, and a preparation method therefor.

1 .- 21 . (canceled) 
     
     
         22 . A method for bowel preparation before endoscopy comprising:
 administering a colonic purgative composition comprising sodium picosulfate, potassium sulfate, magnesium sulfate and a water-soluble binder,
 wherein the water-soluble binder is selected from the group consisting of polyvinylpyrrolidone, copolymers of vinylpyrrolidone and vinyl acetate, polyethylene glycol and combinations thereof; and 
 wherein a total dose of sodium picosulfate, potassium sulfate and magnesium sulfate before endoscopy is 22.26 to 24.62 g. 
   
     
     
         23 . The method according to  claim 22 , wherein the colonic purgative composition further comprises simethicone. 
     
     
         24 . The method according to  claim 23 , wherein the magnesium sulfate is magnesium sulfate tetrahydrate. 
     
     
         25 . The method according to  claim 24 , wherein a daily dose of each component before colonoscopy is:
 Sodium picosulfate: 7.5 to 10.5 mg,   Potassium sulfate: 2.5 to 3.3 g,   Magnesium sulfate tetrahydrate: 5.7 to 9 g, and   Simethicone: 140 to 200 mg.   
     
     
         26 . The method according to  claim 25 , wherein the daily dose of each component before colonoscopy is:
 Sodium picosulfate: 7.5 to 10 mg,   Potassium sulfate: 2.5 to 3.13 g,   Magnesium sulfate tetrahydrate: 5.72 to 8.58 g, and   Simethicone: 160 to 200 mg.   
     
     
         27 . The method according to  claim 24 , wherein the colonic purgative composition further comprises a water-soluble lubricant. 
     
     
         28 . The method according to  claim 27 , wherein the water-soluble lubricant is selected from the group consisting of sodium benzoate, sodium lauryl sulfate and combinations thereof. 
     
     
         29 . The method according to  claim 27 , wherein the colonic purgative composition further comprises a water-soluble antioxidant. 
     
     
         30 . The method according to claim  9 , wherein the water-soluble antioxidant is selected from the group consisting of ascorbic acid, sodium ascorbate, fumaric acid, malic acid, potassium metabisulfite, sodium pyrosulfite, and combinations thereof. 
     
     
         31 . The method according to  claim 22 , wherein the total dose of sodium picosulfate, potassium sulfate, magnesium sulfate and simethicone in combined dosage forms before endoscopy is 22.57 to 24.95 g. 
     
     
         32 . The method according to  claim 22 , wherein the colonic purgative composition is administered in divided doses once on the day before the endoscopy and once on the day of the endoscopy. 
     
     
         33 . The method according to  claim 22 , wherein the colonic purgative composition is administered in divided doses of 10 tablets the day before the endoscopy and 10 tablets on the day of the endoscopy. 
     
     
         34 . A method for preparing a colonic purgative composition, comprising:
 mixing a first mixture comprising potassium sulfate, magnesium sulfate and simethicone; and a second mixture comprising sodium picosulfate, a water-soluble binder and a solvent,
 wherein the water-soluble binder is selected from the group consisting of polyvinylpyrrolidone, copolymers of vinylpyrrolidone and vinyl acetate, polyethylene glycol and combinations thereof. 
   
     
     
         35 . The method for preparing a colonic purgative composition according to  claim 34 , wherein the solvent is ethanol.