Method of making a composition with a film-coated porous material

Abstract

The present invention relates to a method of making a composition comprising a film-coated porous material and the corresponding composition. The invention further relates to the use of this product in cosmetic skin treatment and treatment of stagnating wounds, split skin graft and ulcers.

1 . A method of making a composition comprising a porous material, wherein said porous material is essentially flat and comprises a plurality of open and interconnected pores with pore surfaces, comprising the steps of:
 a) Providing a porous material, wherein said porous material is essentially flat and comprises a plurality of open and interconnected pores with pore surfaces, wherein the density of said porous material is in the range of from 0.01 to 1 g/cm 3 , preferably in the range of from 0.02 to 0.05 g/cm 3 , most preferred in the range of from 0.02 to 0.04 g/cm 3  and wherein said pores have an average diameter in the range of from 10 to 150 μm;   b) Providing a coating solution, wherein the viscosity of said coating solution is in the range of from 5 to 20 Pa·s, preferably from 8 to 15 Pa·s, more preferably from 10 to 14 Pa·s;   c) Providing an applicator means for applying the coating solution onto the surface of said porous material, wherein said applicator means comprises a slot-die;   d) Applying a quantitative amount of the coating solution onto the surface of said porous material to coat said porous material and form a liquid layer by relatively moving said porous material and the applicator means with respect to each other at a speed in the range of from 0.1 to 10 m per minute;   e) Drying said liquid layer.   
     
     
         2 . The method of making a composition comprising a porous material according to  claim 1 , wherein the density of said porous material increases by 10 to 30%, preferably by 10 to 20% after the coating. 
     
     
         3 . The method of making a composition comprising a porous material according to  claim 1 , wherein the quantitative amount of the coating solution applied onto the surface of said porous material in step d) is in the range of from 0.5 to 200 g/m 2 , preferably in the range of from 10 to 100 g/m 2 , most preferred in the range of from 10 to 30 g/m 2 . 
     
     
         4 . The method of making a composition comprising a porous material according to  claim 1 , wherein said coating solution comprises a solvent component and a film forming component. 
     
     
         5 . The method of making a composition comprising a porous material according to  claim 4 , wherein said solvent component is water. 
     
     
         6 . The method of making a composition comprising a porous material according to  claim 5 , wherein the content of water in said coating solution is in the range of from 0.5 to 50 wt %, preferably in the range of from 2 to 35 wt %, more preferably in the range of from 3 to 30 wt %. 
     
     
         7 . The method of making a composition comprising a porous material according to  claim 4 , wherein said film forming component is selected from the group consisting of hyaluronic acid (HA), polyacrylate, polyurethane and polysaccharides, such as alginate, nanocellulose, or carboxymethylcellulose (CMC), or mixtures thereof. 
     
     
         8 . The method of making a composition comprising a porous material according to  claim 1 , wherein said biomaterial is collagen. 
     
     
         9 . A composition comprising a porous material obtainable by a method according to  claim 1 . 
     
     
         10 . A composition comprising
 a porous substrate comprising a first major surface and a second major surface, wherein said porous substrate is essentially flat and comprises a plurality of open and interconnected pores with pore surfaces extending through the porous substrate from the first major surface to the second major surface, wherein said pores have an average diameter in the range of from 10 to 150 μm;   a coating on the first major surface and/or on the second major surface of said porous substrate, wherein said coating comprises hyaluronic acid (HA), polyacrylate, polyurethane or polysaccharides, such as alginate, nanocellulose, or carboxymethylcellulose (CMC), or mixtures thereof;   characterized in that said composition has water absorption in the range of from 10 to 50 g per g of said composition, preferably from 20 to 40 g per g of said composition.   
     
     
         11 . The composition according to  claim 10 , wherein said coating in the coated porous material is bound to the first major surface and/or on the second major surface of said porous substrate through non-covalent bonds. 
     
     
         12 . The composition according to  claim 10 , wherein the coating on the first major surface and/or on the second major surface of the substrate further comprises water. 
     
     
         13 . The composition according to  claim 10 , wherein the amount of the coating in said composition is in the range of from 0.1 to 10 wt %, preferably from 0.5 to 3 wt % in relation to the weight of said composition. 
     
     
         14 . The composition according to  claim 10  for use as a medicament. 
     
     
         15 . The composition according to  claim 10  for use in the treatment of stagnating wounds, split skin graft and ulcers.